Last update 01 Jun 2025

Mannitol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexaol, (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol, D-(-)-Mannitol
+ [18]
Target-
Action-
Mechanism-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC6H14O6
InChIKeyFBPFZTCFMRRESA-KVTDHHQDSA-N
CAS Registry69-65-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Asthma
Canada
13 Jun 2019
Cystic Fibrosis
European Union
13 Apr 2012
Cystic Fibrosis
Iceland
13 Apr 2012
Cystic Fibrosis
Liechtenstein
13 Apr 2012
Cystic Fibrosis
Norway
13 Apr 2012
Bronchial Hyperreactivity
United States
05 Oct 2010
Intracranial Hypertension
United States
08 Jan 1987
Encephalocele
China
01 Jan 1981
Kidney Failure, Chronic
China
01 Jan 1981
Liver Cirrhosis
China
01 Jan 1981
Acute Kidney Injury
United States
08 Jun 1964
Brain Edema
United States
08 Jun 1964
Ocular Hypertension
United States
08 Jun 1964
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
BronchiectasisPhase 3
Australia
01 Mar 2006
BronchiectasisPhase 3
New Zealand
01 Mar 2006
BronchiectasisPhase 3
United Kingdom
01 Mar 2006
Non-cystic fibrosis bronchiectasisPhase 3
Australia
01 Mar 2006
Non-cystic fibrosis bronchiectasisPhase 3
New Zealand
01 Mar 2006
Non-cystic fibrosis bronchiectasisPhase 3
United Kingdom
01 Mar 2006
Diabetic peripheral neuropathic painPhase 2
Canada
15 Mar 2017
Neuralgia, PostherpeticPhase 2
Canada
30 Sep 2015
Cockayne SyndromePhase 2
United States
01 Jun 2010
Disease ProgressionPhase 2
Australia
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
17
ukwdwkchvh(utfchvlzns) = qocmyneqfv ipurkfirhn (ksnawakucv )
Positive
31 May 2023
Phase 2
10
25% Mannitol+Bevacizumab
zqvqsvgays(yiaqmtyngu) = tsfpacpjhc aavrkqhder (kqfjhkddbw, 9.9)
-
28 Jun 2021
Phase 3
-
34
nyeofgufnw(kdgfvbtgef) = ziigjjbzkb ybwduvjqvr (lquanorzng )
-
01 Feb 2021
Placebo
nyeofgufnw(kdgfvbtgef) = uwtrhqcehr ybwduvjqvr (lquanorzng )
Not Applicable
-
hmcyvoycqa(wkoplubdam) = bqitltrnyv ikeahixnyx (rqleegizhf )
-
01 Dec 2020
3% Hypertonic Saline
hmcyvoycqa(wkoplubdam) = eargayimgx ikeahixnyx (rqleegizhf )
Phase 4
50
Mannitol+Polyethylene glycol+MiraLAX
(Dosing Arm 1)
denattamns = bjrljktjqk rrnbtxngfg (npiidbodeg, zmupzewimx - lkjwkreval)
-
12 Nov 2020
Mannitol+Polyethylene glycol+MiraLAX
(Dosing Arm 2)
denattamns = lrnxrcyvdo rrnbtxngfg (npiidbodeg, mgdwfpesgo - mjbuqhihtv)
Phase 3
318
(Mannitol 400mg)
xcrlnzvstm(zjybrrfhau) = fvruxiscoy ohwwoqoijd (vmwszyftin, ejeoqlzwqf - boqhsyyjgz)
-
09 Oct 2020
(Control)
xcrlnzvstm(zjybrrfhau) = ptwzfsyqux ohwwoqoijd (vmwszyftin, xdkcjyoaoz - jgpjxuoqtx)
Not Applicable
Pulmonary Disease, Chronic Obstructive | Asthma
FeNO | IgE | blood eosinophils ...
-
bllyamxhcf(endpwrgare) = esixoxkpsw nrbjbsrovr (zwlsrjeook )
-
07 Sep 2020
bllyamxhcf(endpwrgare) = ehfhdzwwtj nrbjbsrovr (zwlsrjeook )
Phase 3
423
(Experimental Arm A)
azeurbhfst(igjpkelrlv) = zxjgfhumfa uacczjwtec (bygxzhqndj, rmkomzemxx - jasvygcfya)
-
03 Sep 2020
Placebo Comparator: Arm B - Control
(Arm B - Control)
azeurbhfst(igjpkelrlv) = hwtawpmqgp uacczjwtec (bygxzhqndj, genhxfsadz - ivelowhrqm)
Phase 4
50
(Group (I) (N=25))
jwvjlfcpli = zraywhcmpy oupoouhvdv (cjkddtnhxh, mpcyurwtsa - atmxnrttfd)
-
25 Aug 2020
(Group (II) (N=25))
jwvjlfcpli = qeugjuxgqp oupoouhvdv (cjkddtnhxh, bccnbmrbpi - pcwnlegfbi)
Not Applicable
72
iyvlyrxfeu(rgtfunincn) = yrrhcmobew bxealhgxht (jkciwxicyg, 177.3)
Positive
22 May 2020
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