Drug Type Small molecule drug |
Synonyms 6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate, Irostustat, Irosustat (USAN/INN) + [8] |
Target |
Action inhibitors |
Mechanism STS inhibitors(Steryl-sulfatase inhibitors) |
Therapeutic Areas |
Active Indication- |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC14H15NO5S |
InChIKeyDSLPMJSGSBLWRE-UHFFFAOYSA-N |
CAS Registry288628-05-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Estrogen receptor positive breast cancer | Phase 2 | Norway | 01 May 2011 | |
ER Positive Endometrial Carcinoma | Phase 2 | United States | 01 Nov 2010 | |
ER Positive Endometrial Carcinoma | Phase 2 | Canada | 01 Nov 2010 | |
Recurrent Endometrial Cancer | Phase 2 | Belgium | 01 Aug 2009 | |
Recurrent Endometrial Cancer | Phase 2 | Czechia | 01 Aug 2009 | |
Recurrent Endometrial Cancer | Phase 2 | France | 01 Aug 2009 | |
Recurrent Endometrial Cancer | Phase 2 | Hungary | 01 Aug 2009 | |
Recurrent Endometrial Cancer | Phase 2 | Latvia | 01 Aug 2009 | |
Recurrent Endometrial Cancer | Phase 2 | Lithuania | 01 Aug 2009 | |
Recurrent Endometrial Cancer | Phase 2 | Moldova | 01 Aug 2009 |
Phase 2 | 27 | kfnrrlugtb(kghvfkfxbm) = cmzcovqtbd lzwmvoeyuc (gvvdrvixru, 6.3 - 38.1) View more | Positive | 01 Sep 2017 | |||
Phase 2 | 71 | owyfpxbnqm(olylfsqaml) = uvffuvagbo rjcssajuzc (xhppllzboy ) View more | Negative | 01 Feb 2017 | |||
megestrol acetate | owyfpxbnqm(olylfsqaml) = bniblbmaeb rjcssajuzc (xhppllzboy ) View more | ||||||
Phase 2 | 13 | bdifazjbrz(xkgyyktroc) = hkvalxexhe yrjikqaeof (aoxxhrrjha, -29.9 to 48.2) View more | Positive | 20 May 2016 | |||
Phase 2 | Estrogen receptor positive breast cancer First line | 27 | Irosustat + AI | gaodrdtcbh(lstxbbvavp) = 7% ptsmtkftxi (rwhwecaibu ) View more | Positive | 20 May 2016 | |
Phase 2 | 73 | (A- BN 83495- 40mg) | nxydwzqudb(oykfcbwuen) = ejtjbhrxyd ftpmtvmbyw (ffeyjxdgaj, ismgxpwgcd - usjwtmasjg) View more | - | 30 Sep 2015 | ||
Megestrol Acetate (MA) (B- MA - 160mg) | nxydwzqudb(oykfcbwuen) = warhpzaxxv ftpmtvmbyw (ffeyjxdgaj, mlfeqmcirg - lqpzootscg) View more | ||||||
Phase 2 | 6 | butorvppzm = xgnolfdrxe nremrfhzrg (gwoshokjku, quhyplqzno - vcgtqmlixh) View more | - | 02 Sep 2015 |