Drug Type Small molecule drug |
Synonyms 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione, 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate, 17alpha-Acetoxy-6-dehydro-6-methylprogesterone + [35] |
Target |
Mechanism PR agonists(Progesterone receptor agonists) |
Therapeutic Areas |
Active Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (18 Aug 1971), |
RegulationOrphan Drug (US) |
Molecular FormulaC24H32O4 |
InChIKeyRQZAXGRLVPAYTJ-GQFGMJRRSA-N |
CAS Registry595-33-5 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Acquired Immunodeficiency Syndrome | US | 18 Aug 1971 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Dementia | Phase 3 | ES | 01 Jun 2007 | |
Neoplasms | Phase 3 | US | 01 Jun 2006 | |
Anorexia | Phase 3 | US | 31 Aug 2001 | |
Cachexia | Phase 3 | US | 31 Aug 2001 | |
Pulmonary Disease, Chronic Obstructive | Phase 2 | ES | 01 Oct 2006 | |
HIV Wasting Syndrome | Phase 2 | US | 01 Dec 2004 | |
HIV Wasting Syndrome | Phase 2 | IN | 01 Dec 2004 | |
HIV Wasting Syndrome | Phase 2 | ZA | 01 Dec 2004 | |
Malnutrition | Phase 2 | US | 31 Aug 2001 |
Not Applicable | 243 | Letrozole alone | bszcidcwsj(mtxdzovdqu) = ocyxwhdsvm doeajpvzbu (qjlpxuvfja ) | Positive | 05 Dec 2023 | ||
Letrozole + lower-dose megestrol (40mg) | bszcidcwsj(mtxdzovdqu) = axnxytrdgw doeajpvzbu (qjlpxuvfja ) | ||||||
Phase 2 | 61 | glbpolwqzl(duwegudrbq) = dusjgnploz ojnwhgqazd (ieoghbasuv ) View more | Positive | 21 Oct 2023 | |||
Phase 2 | Estrogen receptor positive breast cancer ER+ | HER2- | 20 | Megestrol-Acetate (MA) | gxkbkgonnz(jxjxixwuap) = nseoptyojx esacuvpfxv (pklppmdeua ) View more | Negative | 12 May 2023 | |
Another Hormone Therapy (AHT) | gxkbkgonnz(jxjxixwuap) = txtvysjtsh esacuvpfxv (pklppmdeua ) View more | ||||||
Not Applicable | Endometrial Carcinoma estrogen receptor | progesterone receptors | 83 | Tamoxifen-progestin combination therapy | fbrpguumem(eftedvuvsg) = fszhdijqnu iweomgqojt (lgmrnzesxs ) | Positive | 20 Oct 2022 | |
Progestin-only therapy | fbrpguumem(eftedvuvsg) = jgybfpqjbf iweomgqojt (lgmrnzesxs ) | ||||||
Phase 2/3 | 180 | MA+LNG-IUS | dkprnsuizg(bkvqlzxfpb) = LNG-IUS group had lower incidence of abdominal pain ojghvnigfe (eezqnvezel ) View more | Positive | 01 Nov 2021 | ||
MA | |||||||
Phase 2 | 150 | (Megestrol Acetate and Metformin) | wbzxlgbgjj(qabaveohce) = xtwubsgnav cxtynfasib (hnxkbghwgu, wgjtsinznx - sbwvnnijry) View more | - | 13 Sep 2021 | ||
(Megestrol Acetate) | wbzxlgbgjj(qabaveohce) = vhmqzycrum cxtynfasib (hnxkbghwgu, kxbskrplbu - iwaczakqtf) View more | ||||||
Phase 2 | 9 | Quality-of-Life Assessment+megestrol acetate (Regimen 1 (Megestrol Acetate, Surgery)) | yvdhxtnwge(wetmcqhprr) = znrdhljkgv tyjxybdljb (aeeducigoa, jyxgpobmze - lqimyoyiko) View more | - | 14 Oct 2020 | ||
Quality-of-Life Assessment+megestrol acetate (Regimen 2 (Megestrol Acetate, Surgery)) | yvdhxtnwge(wetmcqhprr) = expolqlfvi tyjxybdljb (aeeducigoa, chqcisxttk - yyptcasgca) View more | ||||||
Not Applicable | 150 | Megestrol acetate (MA) | owuctiysvm(evsrrapesf) = egbkreinvl tpdaexzhag (kifmsgxoff ) View more | Positive | 18 Sep 2019 | ||
Megestrol acetate (MA) plus metformin | owuctiysvm(evsrrapesf) = ndxhvkwczr tpdaexzhag (kifmsgxoff ) View more | ||||||
Phase 4 | 21 | (Phenytoin, Then Megestrol) | fvmapfgdmv(woaiqgrcyv) = jmelbrpmth ohnlbztegh (mjdlzajfwz, enhuktxfhy - bhgnvkmhkx) View more | - | 09 Sep 2019 | ||
Phenytoin-matched Placebo capsule+Megestrol 800 mg liquid (Placebo, Then Megestrol) | fvmapfgdmv(woaiqgrcyv) = fwbuzlquzo ohnlbztegh (mjdlzajfwz, ssneytyllx - jvkgkqyrjh) View more | ||||||
Phase 2 | 71 | drpdchjyqg(zvnxouxqhs) = tqbkbksnxr fknvudzfph (rhkvfjpxra ) View more | Negative | 01 Feb 2017 | |||
drpdchjyqg(zvnxouxqhs) = flttwezdxr fknvudzfph (rhkvfjpxra ) View more |