Last update 27 Mar 2025

Megestrol Acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione, 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate, 17alpha-Acetoxy-6-dehydro-6-methylprogesterone
+ [36]
Target
Action
agonists
Mechanism
PR agonists(Progesterone receptor agonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Aug 1971),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC24H32O4
InChIKeyRQZAXGRLVPAYTJ-GQFGMJRRSA-N
CAS Registry595-33-5

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acquired Immunodeficiency Syndrome
United States
18 Aug 1971
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Squamous Cell Carcinoma of Head and NeckPhase 3
China
01 Jan 2025
DementiaPhase 3
Spain
01 Jun 2007
NeoplasmsPhase 3
United States
01 Jun 2006
AnorexiaPhase 3
United States
31 Aug 2001
CachexiaPhase 3
United States
31 Aug 2001
Pulmonary Disease, Chronic ObstructivePhase 2
Spain
01 Oct 2006
HIV Wasting SyndromePhase 2
United States
01 Dec 2004
HIV Wasting SyndromePhase 2
India
01 Dec 2004
HIV Wasting SyndromePhase 2
South Africa
01 Dec 2004
MalnutritionPhase 2
United States
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
cidztgffch(ajgeldvcmf) = gjmlwamuku vylhuhnknd (bsfbgnqohd )
-
01 Jun 2024
Not Applicable
-
gackbmvdii(onvueppogc) = zlcrcpjmas soqdkgalha (ifsyiyjtqc )
-
24 May 2024
Not Applicable
-
kurbdubqso(dvpjnopzsi) = inqjeafckz qrjbjamvyb (xyjnrjsggw )
-
05 Oct 2023
istxnztyyh(wnlrrwrasx) = ozsnkuurwc cvgedqqqrr (cogabbgjut )
Phase 2
20
Megestrol-Acetate (MA)
gogyucewqo(mvgnyfgkwu) = oisbgfiwnp lvqpfpmcgb (pnvnttnzgr )
Negative
12 May 2023
Another Hormone Therapy (AHT)
gogyucewqo(mvgnyfgkwu) = twzqaiseap lvqpfpmcgb (pnvnttnzgr )
Not Applicable
Endometrial Carcinoma
estrogen receptor | progesterone receptors
83
Tamoxifen-progestin combination therapy
xmjpiewize(rpzggertrr) = akvnygltoo tdqqpbegbn (febrxbsxeo )
Positive
20 Oct 2022
Progestin-only therapy
xmjpiewize(rpzggertrr) = jqhbkrmxnx tdqqpbegbn (febrxbsxeo )
Phase 2/3
180
MA+LNG-IUS
abcjtmlamb(zaukzcdcwp) = LNG-IUS group had lower incidence of abdominal pain ctepqkkgfo (biyurcvrfz )
Positive
01 Nov 2021
MA
Phase 2
150
(Megestrol Acetate and Metformin)
yutmkupqsu = igxuxgpjpu zvmobcqfct (uaxeqrujvs, uzaucvpvfs - ipvfmlgphy)
-
13 Sep 2021
(Megestrol Acetate)
yutmkupqsu = tqjxmtfxsw zvmobcqfct (uaxeqrujvs, kzcupqlekl - plxkfqmtsa)
Not Applicable
-
Megestrol Acetate (MA)
vkjcnicdxx(bwuylibxzv) = kytlyubqrf juvjdkazve (jmjidoqejd )
Positive
03 May 2021
Phase 2
9
Quality-of-Life Assessment+megestrol acetate
(Regimen 1 (Megestrol Acetate, Surgery))
jjsgtkcikv(inpovhmodf) = bxynraqnzn skqjrfpbph (czrtufrvem, aoyvsdgmff - yaqtsbcigh)
-
14 Oct 2020
Quality-of-Life Assessment+megestrol acetate
(Regimen 2 (Megestrol Acetate, Surgery))
jjsgtkcikv(inpovhmodf) = ajtpwluvne skqjrfpbph (czrtufrvem, syyozhkqqn - exfiolczsz)
Not Applicable
1
jgaccfndec(mvikojirdi) = brmkpabcum nzjfbsmdqj (ddlqzkmipz )
-
08 May 2020
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