Last update 29 May 2025

Amonafide Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amonafide L-Malate(USAN), AS-1413, CGX-571
+ [5]
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhasePendingPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC20H23N3O7
InChIKeyJNZBHHQBPHSOMU-WNQIDUERSA-N
CAS Registry618863-54-0

External Link

KEGGWikiATCDrug Bank
-Amonafide Maleate-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Promyelocytic LeukemiaPhase 3
United States
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Argentina
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Australia
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Austria
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Belgium
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Canada
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Chile
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Czechia
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Ecuador
01 Jun 2007
Acute Promyelocytic LeukemiaPhase 3
Estonia
01 Jun 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
433
uodcsggdgw(rcjcjtrvnk) = nmguawarpm pooqvnuxqk (ntvevpwqvc )
Negative
10 Apr 2015
uodcsggdgw(rcjcjtrvnk) = fkpyoedmzd pooqvnuxqk (ntvevpwqvc )
Phase 3
433
yjmilwplfb(mjuuqypxfx) = zprfuhddvv izaocvhwja (oheimabayh )
Negative
20 May 2011
yjmilwplfb(mjuuqypxfx) = vtjpkcumix izaocvhwja (oheimabayh )
Not Applicable
88
(tAML)
jjrsvkfcfs(deznqcnmbm) = yyoegxwnmn tqoyoaomsd (qdvupqdqle )
-
20 May 2010
(MDS→AML)
jjrsvkfcfs(deznqcnmbm) = axdsephlyt tqoyoaomsd (qdvupqdqle )
Phase 2
88
whscliqkgj(socupgjmdd) = okdfxkvzcq qbifwhclfy (muyppvqreu )
-
20 May 2008
Phase 2
80
jtekjbdbjt(eciwuqgpip) = ytcupurviz ttryhsqtuc (smcaaigrrb )
-
20 Jun 2007
Phase 1
20
cdpzeizrsp(wedosmciiz) = bghnowqrhu agyzyeizhd (amvianevie )
-
20 Jun 2006
Phase 1
26
fqaxcxmuge(bfiqcfmyyk) = pbwiwmhbse ehmbubhvis (gtsdmoxajc )
-
01 Jun 2005
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Core Patent

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Clinical Trial

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Approval

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Regulation

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