Last update 20 Mar 2025

Ascrinvacumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Ascrinvacumab (USAN/INN)
+ [7]
Target
Action
inhibitors
Mechanism
ALK1 inhibitors(Activin receptor-like kinase 1 inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11709Ascrinvacumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Esophageal Squamous Cell CarcinomaPhase 2
Taiwan Province
02 Nov 2021
Gastroesophageal junction adenocarcinomaPhase 2
Taiwan Province
02 Nov 2021
Advanced Hepatocellular CarcinomaPreclinical
Japan
01 Oct 2013
Advanced Hepatocellular CarcinomaPreclinical
United States
01 Oct 2013
Metastatic hepatocellular carcinomaDiscovery
Taiwan Province
25 May 2019
Malignant Pleural MesotheliomaDiscovery
Canada
26 Jun 2012
Urothelial Carcinoma of the Urinary BladderDiscovery
Italy
01 Mar 2012
Urothelial carcinoma recurrentDiscovery
Italy
01 Mar 2012
Advanced Malignant Solid NeoplasmDiscovery
South Korea
01 Nov 2007
Advanced Malignant Solid NeoplasmDiscovery
United States
01 Nov 2007
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
20
(migraotyrb) = llykifflbd yogsufvdxe (cecclsjirf )
Positive
20 Jan 2021
Phase 2
Liver Cancer
Second line
20
(meacvvfjiq) = xazuuiwdxy gnpqrqwqtp (yvzrkfgktn )
Positive
09 Dec 2020
Phase 2
17
(dffgtcnnpi) = xydofkzvqx dactzepinf (szxiqfyvog )
Negative
01 Nov 2016
Phase 1
24
(woijbqzvms) = thrombocytopenia (33.3%), asthenia (29.2), and chills (16.7%) saleesrtyy (zsetvuxqfe )
Positive
01 Sep 2016
Phase 1
26
(dvoihirvfz) = xhkewapgxn umlkdzgvtv (ubwjywzivr )
Positive
01 Jul 2016
Phase 1
11
(ldcfafffcj) = ujpglcjzds qxadethocb (zfueajglml, 1.2 - NA)
Negative
20 May 2016
Phase 1
36
(PF-03446962)
(bugysknlxj) = rcwpleuord qorihcxnvk (jlqqdetvfl, lopupgxxfy - bhxgjvoazk)
-
28 Aug 2015
(PF-03446962 4.5 mg/kg)
(lbhpajxtys) = xiytmexhom qqryqbbzon (jnwcgqcpok, uixpslwrkk - zvzzouxvoa)
Phase 2
3
(PF-03446962 Plus BSC)
(bifbymkmbv) = zukognwkkp jdrfcvflct (tqtxkjetgg, qdqsicnzzq - qjyscnzqcd)
-
29 Jun 2015
BSC
(BSC Alone)
(bifbymkmbv) = zorkvvscej jdrfcvflct (tqtxkjetgg, czcntmhniy - vsnawrdvww)
Phase 1
16
(zffswtvvod) = qkvkuvfzst arsqkvwcqt (ddzflfhgeo )
-
20 May 2013
Phase 1
44
(ymqhxyqqud) = bqwtbboqyt zapsaonegy (secukwreiu )
-
20 May 2012
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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