Randomized, Multicenter, Double-blind, Parallel, Placebo-controlled Study to Investigate the Safety and Exploratory Efficacy of the Absorbable Oxandrolone Implant as an Adjuvant Treatment in Rehabilitation Following Anterior Cruciate Ligament (ACL) Surgical Reconstruction (IMOX Study)

Rehabilitation of knee stability and function after anterior cruciate ligament (ACL) reconstruction is slow and costly. The use of anabolic steroids, such as oxandrolone, may aid in the recovery of muscle mass and strength, as well as functional capacity. Oxandrolone, derived from dihydrotestosterone, has high anabolic activity and low androgenic activity (a 13:1 ratio), making it more effective in promoting weight gain with fewer side effects compared to other steroids. Registered by the FDA and previously by ANVISA (National Health Surveillance Agency (Brazil), it is indicated for cases of post-trauma or post-surgery weight loss. The subdermal use of oxandrolone implants is proposed to release the drug directly into the bloodstream, improving efficacy and reducing issues related to oral administration. This study evaluates the safety and tolerability of the absorbable subdermal oxandrolone implant for 24 weeks versus placebo implant in both men and women as an adjuvant treatment during rehabilitation following anterior cruciate ligament (ACL) surgical reconstruction. The serum and pharmacokinetic profile of the oxandrolone implant will be monitored.

Start Date16 Jun 2025

Sponsor / Collaborator

Science Valley Research Institute

RBR-2hs894w

/ Not yet recruitingPhase 2IIT

Effects of Oxandrolone on clinical outcomes and muscle mass in patients with Septic shock: a randomized clinical trial - ONSET Oxandrolona iN SEpTic patients

Start Date01 Dec 2023

Sponsor / Collaborator-

NCT05893069

/ SuspendedPhase 4IIT

Ability of Oral Oxandrolone to Aid in Rehabilitation and Outcomes of Multiligament Knee Reconstructions: A Double-Blind, Randomized Controlled Trial

This study is about healing after a rmultiligament knee reconstruction procedure. We hope to learn if a biologic medication: Oxandrolone, a synthetic derivative of the human hormone Testosterone (the principal male sex hormone and an anabolic steroid), given for 12 weeks is effective in aiding in the healing process and restoring muscle mass.

Start Date01 Jul 2023

Sponsor / Collaborator

University of Southern California

100 Clinical Results associated with Oxandrolone

100 Translational Medicine associated with Oxandrolone

100 Patents (Medical) associated with Oxandrolone

861

Literatures (Medical) associated with Oxandrolone

01 Jun 2025·Drug Testing and Analysis

Changing trends in anabolic‐androgenic steroid use within Scottish prisons: Detection, prevalence, and quantitation

Article

Author: Harries, Richard L. ; Nic Daéid, Niamh ; Norman, Caitlyn ; Nisbet, Lorna A. ; Reid, Robert

Abstract:

Anabolic‐androgenic steroids (AASs) are a subclassification of image performance enhancing drugs (IPEDs). While AAS use is most prevalent among people in athletics, there is also high lifetime prevalence of AAS use among prisoners. This study reports the qualitative detection of AASs in seized samples from the Scottish prisons from 2019–2023. Additionally, methods were developed for the quantitative analysis of AASs using gas chromatography–mass spectrometry (GC–MS) and applied to 61 samples of tablets or powders seized from Scottish prisons between July 2022 and July 2023. Since 2022, there has been an increase in AAS detections in the Scottish prisons. Oxymetholone was the most prevalent AAS, followed by metandienone (methandrostenolone, methandienone), methyltestosterone, oxandrolone, mestanolone (methylandrostanolone), stanozolol, and androstenedione. Multiple AASs were found in 21 samples and 10 samples contained other drugs, including amitriptyline, sertraline, zopiclone, mirtazapine, sildenafil, etizolam, Δ9‐tetrahydrocannabinol, and the synthetic cannabinoid MDMB‐INACA. Most AAS samples were tablets (77.0%), although they were also detected in powders, herbal material, e‐cigarettes, and a fragmented soap bar‐type sample. There was a large variation in the concentration of AASs in the tablets and powders seized from the Scottish prisons, demonstrating AASs are another highly variable component of the polydrug use situation in prisons, the effects of which need to be examined further.

01 Jun 2025·COMPUTERS IN BIOLOGY AND MEDICINE

MiRAGE-DTI: A novel approach for drug–target interaction prediction by integrating drug and target similarity metrics

Article

Author: Abbasian Bajgiran, Yeganeh ; Eskafi, Maryam ; Eslahchi, Changiz ; Hassanali Aragh, Aria ; Moslemi Amirani, Razieh ; Givehchian, Pegah

MOTIVATION:

Accurately predicting drug-target interactions (DTIs) is critical for accelerating drug discovery, repositioning, and development. Traditional experimental methods are often expensive and time-consuming, emphasizing the need for efficient computational models to streamline these processes. To address this challenge, we developed MiRAGE-DTI, a novel computational framework that integrates diverse drug and target similarity measures with robust machine learning techniques to achieve superior predictive accuracy.

RESULTS:

MiRAGE-DTI introduces a novel framework that integrates structural, functional, and interaction-based features into a unified model. Leveraging the strengths of Random Forest classifiers, MiRAGE-DTI ensures robust and interpretable predictions while addressing challenges such as class imbalance and data variability. Comprehensive evaluations across multiple benchmark datasets, including GPCR, IC, NR, and Enzyme, reveal that MiRAGE-DTI consistently outperforms state-of-the-art algorithms such as DTI-CNN, GCNMDA, MVGCN, MMGCN, GraphCDA, DTINet, and MIDTI. It achieves significant improvements in key metrics such as AUROC, AUPR, and accuracy. To validate its predictions, molecular docking studies were conducted, highlighting strong binding affinities for key drug-target interactions, including Oxandrolone-PGR and Metyrapone-CYP2E1, which demonstrate high therapeutic potential. Beyond predictive accuracy, MiRAGE-DTI has practical implications in drug repositioning and personalized medicine, as well as the potential to streamline preclinical workflows. Its ability to uncover novel drug-target relationships enhances the understanding of molecular mechanisms underlying diseases, paving the way for innovative therapeutic strategies. Furthermore, by predicting off-target interactions and potential side effects, MiRAGE-DTI contributes to improving drug safety profiles and regulatory evaluations.

CONCLUSION:

MiRAGE-DTI represents a versatile and powerful tool for advancing drug discovery and development. Its ability to identify novel therapeutic opportunities, repurpose existing drugs, and enable precision medicine highlights its transformative potential in tackling unmet medical needs. The framework's robust performance, validated predictions, and wide-ranging practical applications position MiRAGE-DTI as a critical resource for modern drug discovery.

01 Apr 2025·SHOCK

COMBINED EFFECTS OF OXANDROLONE AND EXERCISE ON MUSCLE RECOVERY IN RATS WITH SEVERE BURN AND HINDLIMB UNLOADING

Article

Author: Hundeshagen, Gabriel ; Branski, Ludwik K. ; Wolf, Steven E. ; Song, Juquan ; Baer, Lisa A. ; Kleinhapl, Julia ; El Ayadi, Amina ; Wade, Charles E. ; Palackic, Alen

ABSTRACT:

Background: Loss of muscle mass and strength in patients who have experienced severe burns is dramatic and associated with subsequent functional impairment. Past work has shown that exercise and oxandrolone, an anabolic steroid, individually improve muscle function and muscle mass in severely burned patients. This study aims to evaluate the effect of oxandrolone treatment combined with resistance exercise on muscle atrophy and investigate the protein synthesis and mitochondrial biogenesis pathways in a hindlimb suspension model. Methods: Twenty-four Sprague-Dawley rats received 40% total body surface area (%TBSA) scald burns and were then placed for hindlimb unloading. All animals were randomly grouped into vehicle (corn oil) without exercise (V/NEX), oxandrolone administration (0.1 mg/kg/d) without exercise (OX/NEX), vehicle with exercise (V/EX), or oxandrolone with exercise (OX/EX) (n = 6/group). On day 14, isometric forces of the left plantaris and soleus muscle were measured by using a muscle lever system with dynamic muscle control and analysis software. Fatigue measurement was only performed in the soleus muscle. The tissue of the muscle was then collected for protein extraction. Western blots were performed to study signal alternations and mitochondrial biogenesis pathways. Results: Tetanic force (Po) was significantly increased in the plantaris with exercise rather than with oxandrolone treatment. Fatigue index (FI) was lower, and integration was significantly elevated in the soleus with exercise but not with oxandrolone treatment. Fatigue curve in the soleus further revealed that the average maximum force was achieved in soleus with either oxandrolone treatment or exercise alone independently. Raptor and p-Akt levels are elevated in the OX/EX group, whereas PGC1a expression was not altered. Conclusion: Oxandrolone and resistance exercise have independent positive effects on muscle function recovery in this clinically relevant rodent model of severe burn. Both treatments combined increased signaling pathways by increasing protein synthesis.

News (Medical) associated with Oxandrolone

15 Dec 2024

·www.accesswire.com

Best Legal Steroids: Effective Bodybuilding Steroid Alternatives for Muscle Growth

Closest thing to real steroids to use for cutting and bulking in the bodybuilding industry SAN FRANCISCO, CA / ACCESSWIRE / December 15, 2024 / For many years, professional and amateur bodybuilders have been drawn to the allure of steroids for muscle growth and strength gains, a trend observed by experienced trainers working closely with athletes over decades.But the risks of anabolic androgenic steroids-legal issues, severe side effects, and long-term damage to your health-just aren't worth it. That's why I've turned my attention to legal steroid alternatives.Legal alternatives to Dianabol and Trenbolone, for example, are designed to give you the same benefits as traditional oral and injectable steroids-more muscle, more strength, and more endurance-but without the downsides.The best part? They're legal and available to buy online in the USA.In this guide, I'll take you through the best bodybuilding steroid alternatives that not only deliver amazing results but also support your overall health and performance. Whether you want to bulk up, get lean, or enhance your athleticism, these legal steroid alternatives have you covered.Best Legal Steroids for Sale Online - IntroHere are the most effective and popular muscle building supplements and legal substitutes to traditional anabolic steroids for sale online in the USA.D-Bal Max (Dianabol)Tren-Max (Trenbolone)Crazy Bulk Stacks (4 x combo)Testo Prime (Testosterone)The listed brands and products can be ordered online and have long money back guarantees. Free delivery to the United States, Canada, UK and Australia.Top-Rated Legal Steroids for Bodybuilding:Here is a more in depth explanation of the most effective steroids for sale that are legally available to buy in the USA. Each product is from a reputable manufacturer and can be ordered directly, which passes on savings and ease of communication with customer service.#1 - D-Bal Max - Legal Dianabol SteroidCLICK to view D-Bal Max price, special offers and availabilityAs someone with years of experience in bodybuilding and training both men and women to achieve massive muscle gains, I've used and experimented with countless steroids and supplements.But when it comes to legal alternatives that can produce similar results to anabolic steroids, D-Bal Max is the most effective.D-Bal Max is designed to replicate the muscle-building power of Dianabol, one of the most famous anabolic steroids.Like other legal steroid alternatives, D-Bal Max falls under the category of dietary supplements and is subject to different regulatory standards compared to anabolic steroids.What makes it the top choice is its ability to deliver massive lean muscle growth without the dangerous side effects associated with steroids.I've had clients who wanted to bulk up quickly but were hesitant to use illegal anabolic steroids, and D-Bal Max has consistently provided them with the results they were looking for.What sets D-Bal Max apart is its powerful blend of ingredients that work synergistically to boost muscle size, strength, and endurance.It contains a combination of natural compounds like Pro BCAA Complex, 20-Hydroxyecdysterone, and a Whey Protein Complex, which together enhance protein synthesis, increase nitrogen retention, and improve energy levels.These are the same mechanisms through which Dianabol works, but D-Bal Max does it safely and legally.I've personally seen the transformation in individuals who've used D-Bal Max as part of their training regimen.Their muscles become fuller and stronger, their recovery times are shortened, and they're able to push harder in the gym.The results are not just superficial; they're substantial and sustainable, making D-Bal Max an ideal choice for anyone serious about increased muscle and bodybuilding.If you're looking to get big quickly and want a legal, safe alternative to Dianabol, D-Bal Max is the best option on the market. It delivers powerful results without the risks, and that's why I recommend it to all my clients.#2 - Tren-Max - Legal TrenboloneCLICK for promotions and price on legal Trenbolone - Tren-MaxTrenbolone is another steroid that I've used, and it's similar to Dianabol in that both are incredibly effective for rapid muscle growth and strength gains. However, Trenbolone takes it a step further by offering lean muscle gains without the water retention that often comes with Dbol.When I was looking for a legal alternative that could deliver similar results to Trenbolone, I came across Tren-Max from CrazyBulk, and I have to say, it's the best Trenbolone substitute legally available to buy in the USA.Tren-Max is designed to replicate the powerful anabolic effects of Trenbolone, but without the harsh side effects. Tren-Max is a legal alternative to performance enhancing drugs like Trenbolone, providing similar benefits without the legal and health risks. What makes Tren-Max so effective is its ability to boost muscle mass, strength, and conditioning all at once.It works by increasing nitrogen retention and red blood cell production, which are the same pathways that make Trenbolone so potent. The difference is, Tren-Max does this naturally and legally.Some of the guys I have trained who wanted the muscle density and vascularity that Trenbolone provides, didn't want to risk the severe side effects like "Tren cough," night sweats, or cardiovascular strain. Tren max has been the perfect solution for them.It's packed with natural ingredients like Beta-Sitosterol, Samento Inner Bark, Nettle Leaf Extract, and Pepsin, which together promote serious muscle growth, enhanced fat loss, and improved physical conditioning.The results I've seen with Tren-Max are impressive. My clients have experienced significant gains in muscle hardness and strength, similar to what you'd expect from a Trenbolone cycle, but without the risks associated with steroids.The strength gains are real, and the muscle definition is far more pronounced, giving that chiseled, gym-hardened look.If you're aiming to get ripped and build solid, lean muscle mass while staying on the right side of the law, Tren-Max from CrazyBulk is the way to go.It's a must have for anyone serious about achieving a powerful, shredded physique without compromising their health.#3 - Bulking Stack - Steroid Stack ComboCLICK for details and availability on CRAZY BULK Bulking StackIf you're training someone who's looking for quick and rapid muscle gains, the CrazyBulk Bulking Stack is a combination I strongly recommend.This stack contains the top legal alternatives to some of the most powerful and popular anabolic steroids: Dianabol (Dbol), Trenbolone (Tren), Deca-Durabolin (Deca), and Testosterone. Together, these legal supplements create the ultimate combination for anyone serious about packing on muscle mass fast.The CrazyBulk Bulking Stack is designed to mimic the effects of traditional bulking steroids without the dangerous side effects. The stack includes:D-Bal (Dianabol alternative): Known for rapid muscle and strength gains, D-Bal boosts protein synthesis and nitrogen retention, which are crucial for building muscle mass.Tren-Max (Trenbolone alternative): Tren-Max promotes lean muscle gains, enhanced fat loss, and increased vascularity, giving you that hard, defined look while still packing on size.Deca-max (Deca-Durabolin alternative): Deca-Max supports joint health and boosts collagen synthesis, which is essential for heavy lifting. It also enhances muscle endurance and recovery, allowing for more intense, longer workouts.Testo-Max (Testosterone alternative): Testo-Max powers the entire stack by naturally increasing testosterone levels, which is the key hormone for muscle growth, strength, and overall performance.While the stack does not include human growth hormone, it provides a comprehensive approach to muscle building and performance enhancement.When combined, these four supplements work synergistically to create an anabolic environment in your body that promotes rapid muscle growth, increased strength, and faster recovery times.The stack is perfect for pushing past plateaus and achieving the kind of muscle mass that's typically only possible with steroids, but without the legal risks or harmful side effects.If you're training someone who wants to see dramatic results quickly, the CrazyBulk Bulking Stack is an unbeatable option. It's a safe, legal, and highly effective way to achieve massive muscle gains in a short amount of time, making it the ultimate choice for serious bodybuilders and athletes.#4 - Testo Prime - Legit Testosterone BoosterCLICK to get pricing and discount deals on TestoPrime - Legal TestosteroneIf you're aiming to get ripped and build solid, lean muscle mass while staying on the right side of the law, Tren Max from CrazyBulk is the way to go.It's a game-changer for anyone serious about achieving a powerful, shredded physique without compromising their health.But let me tell you, no matter how effective your stack is, it's going to fall short if your testosterone levels aren't where they need to be. That's where TestoPrime comes into play.This is hands down the best natural testosterone booster I've come across, and it's something I recommend to everyone, whether they're just starting out or they're seasoned lifters looking to break through a plateau.TestoPrime is packed with proven ingredients that naturally elevate your testosterone levels, which is crucial for muscle growth, fat loss, and overall performance.As someone who has experimented with various T-boosters over the years, I can honestly say that TestoPrime delivers results you can feel. The increased energy, improved mood, and enhanced strength are all game-changers in the gym.There were men and women who I have worked with who were struggling with low energy, slow recovery, and just not seeing the muscle gains they were working so hard for.After adding TestoPrime to their regimen, the difference was night and day. Their strength shot up, their recovery times shortened, and they started packing on lean muscle much faster.It's also great for keeping your natural testosterone levels high when you're cycling off other supplements, ensuring that you maintain the gains you've worked so hard for.TestoPrime isn't just about boosting testosterone; it's about optimizing your entire performance. It helps burn stubborn fat, enhances mental clarity, and gives you the edge you need to dominate every workout.If you're serious about taking your training to the next level, TestoPrime is an absolute must-have in your supplement arsenal.#5 - Testol 140 - Legally Available Rad 140RAD 140, also known as Testolone, isn't an anabolic steroid, but it's a powerful SARM (Selective Androgen Receptor Modulator) that's gained a lot of attention in the bodybuilding community for its ability to mimic the effects of traditional steroids without some of the harsh side effects.It's known for delivering impressive muscle gains, enhanced strength, and improved physical conditioning. But if you're looking for a legal and safe alternative that gives you similar results, Testol 140 from CrazyBulk is the way to go.Testol 140 is designed to replicate the incredible muscle-building and fat-burning effects of RAD 140, but with a formula that's 100% natural and legal.One of the things I love about Testol 140 is that it provides the same kind of lean, hard muscle gains that you'd expect from a SARM like RAD 140, but without the risks associated with SARMs, such as potential liver toxicity or hormonal imbalances.I've had clients who were skeptical about legal alternatives, especially when they'd heard so much hype around RAD 140.But after incorporating Testol 140 into their training program, they quickly saw why this SARM is one the most effective legal steroid alternatives for targeted muscle growth. The muscle gains are substantial, and the fat loss is real, helping them achieve that shredded, lean look that's so hard to get naturally. Plus, Testol 140 also boosts energy levels and stamina, allowing you to push harder in your workouts and recover faster afterward.What really sets Testol 140 apart is that it's safe, effective, and doesn't mess with your hormones like some of the harsher substances out there.It's ideal for anyone who wants to experience the benefits of RAD 140-such as increased muscle mass, strength, and endurance-without the legal risks or side effects.If you're serious about building a lean, strong physique naturally, Testol 140 is a smart choice that delivers on its promises.What are Legal Steroids and How Do They Work as Performance Enhancing Drugs?Legal steroids (also known as steroid alternatives) are supplements that mimic the muscle building effects of anabolic steroids but without the side effects.Unlike taking anabolic steroids, which can lead to severe health risks, legal steroids offer a safer alternative for muscle growth and performance enhancement.They work by boosting the body's natural functions such as protein synthesis and nitrogen retention which are needed for muscle growth and strength.Unlike regular anabolic steroids, legal steroids do not have synthetic hormones or harmful substances so it's a safer steroid option for anyone who wants to build muscle and perform better.Benefits of Legal Steroids for Muscle MassLegal steroids is a safer and faster way to build muscle and strength without the risks of anabolic steroids.They help in building lean muscle while losing fat so you get a more defined and athletic body. These supplements also boost athletic performance and endurance so it's a favorite among bodybuilders and athletes.Plus legal steroids don't need post-cycle therapy (PCT) and are generally easier to use than regular anabolic steroids.How to Choose the Legal Steroid Alternative for YouWhen choosing a legal steroid alternative for your needs you need to consider a few things to make sure you get it right.First identify your goals-muscle mass, endurance or fat loss-and choose a product that fits. Look for products with natural ingredients and from companies that have a good safety and effectiveness record.Also read reviews and stay up to date with the latest science. As of 2024 several studies have proven certain natural ingredients in legal steroids and you can make a more educated decision. Always do your research to make sure the product you choose is safe and effective. And always consult with a doctor before starting any new supplement regimen to tailor the product to your needs and health.Safety and Side Effects of Anabolic Steroid UseLegal steroids are generally safe and don't have the same severe side effects as anabolic steroids but you can still experience mild side effects.These can be stomach upset, headaches or allergic reactions depending on your individual sensitivity to certain ingredients. The latest 2024 research confirms that these side effects are rare and mild especially when you follow the recommended dosage.To minimize the risk you need to follow the recommended dosage and consult with a doctor if you experience any adverse effects.Natural Ingredients and Their BenefitsD-Aspartic Acid: A natural amino acid that increases testosterone production which is needed for muscle growth and strength. 2024 research confirms it helps with muscle mass in athletes.Panax Ginseng: A natural herb that improves athletic performance and endurance. 2024 research shows it increases energy and reduces fatigue during intense workouts.L-Carnitine: An amino acid involved in fat metabolism and muscle growth. 2024 science proves it helps with fat loss and preserves lean muscle mass.Tyrosine: An amino acid that helps with muscle growth and recovery. It increases mental focus and reduces stress which can impact workout performance and recovery time.Can Women Use Legal Steroid Alternatives?Yes, women can use steroid alternatives to build muscle, lose fat and support overall fitness goals. But you must use steroids like Anavar for example, that are specifically designed for women to avoid virilization (development of male characteristics).Many legal steroid alternatives on the market are designed for women, powerful but balanced formulas that support lean muscle growth and fat loss without hormonal imbalance. Always follow the recommended dosage and consult with a doctor before starting any supplement to make sure it's aligned with your health and fitness goals.Are Steroid Substitutes Legal in the USA?Yes, steroid substitutes are 100% legal in the United States and available to buy online and in stores. These alternatives are made from natural ingredients and do not contain synthetic compounds found in androgenic anabolic steroids, so they are safe and legal to use.But you must choose products from reputable companies that are transparent with their ingredients and manufacturing process. Follow the recommended dosage to ensure safety and effectiveness.Before-After Results of the Best Steroid SubstitutesD-Bal MAX: Users get massive muscle gain and strength after using D-Bal MAX. It's praised for mimicking the effects of Dianabol without the side effects, so it's a top choice for those who want to bulk up fast and safely.CrazyBulk Bulking Stack: This stack combines several legal steroid substitutes and users get impressive muscle gain, strength and overall athletic performance. It's perfect for those who are under intense training and want to maximize their muscle building potential.TestoPrime: TestoPrime is highly recommended for its ability to boost testosterone levels naturally and users get massive muscle gain, strength and fat loss. Users also get more energy and faster recovery, so it's a top choice for those who want to transform their body.How to Choose the Best Over the Counter Steroid SubstitutesWhen choosing the best over the counter steroid substitutes, prioritize products made from natural ingredients and from reputable companies. Start by reading reviews and research the product to make sure it has a good safety and effectiveness record.Look for legal steroids online that are tested and backed by science or positive user reviews. And always consult with a doctor before starting any new supplement to ensure you're healthy and not taking any medications. This way you can choose the right and effective steroid alternative for your needs.Summary - Legal Steroid Alternatives and Dietary Supplements for SaleSo there you have it, legal steroid alternatives are a powerful and safe way to increase muscle growth, strength and athletic performance without the risks of anabolic steroids. These products like D-Bal MAX, CrazyBulk Bulking Stack and TestoPrime deliver impressive results by using natural ingredients that are scientifically backed and tailored to your goals.Whether you want to bulk up, lose fat or just overall physical conditioning these legal steroid alternatives are the solution. They are legal, available and designed to help you peak performance safely. Just remember, the key to success with any supplement is to choose products from reputable companies, follow the dosage and consult with a doctor to make sure they are suitable for your individual health and fitness goals.FAQWhere to buy steroids online?You can buy steroids online but in many countries including the US it's illegal to buy without a prescription. However you can buy legal steroid alternatives which are safe and work from reputable websites like CrazyBulk which specializes in natural supplements that mimic the effects of anabolic steroids.What's the best natural steroid for lean mass?The best natural supplement for lean mass is often considered to be a product like TestoPrime which boosts testosterone levels naturally and supports muscle growth and fat loss. Another popular one is Trenorol from CrazyBulk which mimics the effects of Trenbolone and gives lean muscle gains without water retention.Is buying steroids online legal?In many countries including the US it's illegal to buy anabolic steroids online without a prescription. However buying legal steroid alternatives which are made from natural ingredients and don't contain synthetic hormones is legal and can be done through online retailers.What are the safest steroid alternatives online?The safest steroid alternatives are those made from natural ingredients and sold by reputable companies. Products like D-Bal MAX, Trenorol and TestoPrime are popular ones that mimic the effects of anabolic steroids but are legal and safe to use. They are available to buy online.Can women use legal steroid alternatives?Yes women can use legal steroid alternatives but make sure to choose products designed for women to avoid side effects. Products like CrazyBulk's Anvarol and Winsol are popular for women who want to build lean muscle and burn fat safely.How do I know I'm buying safe and legal steroid alternatives online?To make sure you're buying safe and legal steroid alternatives, buy from well known companies with good reviews and transparent ingredient lists. Look for products made from natural ingredients and tested for safety and effectiveness. Consult with a healthcare professional before starting any new supplement.Top Natural Steroids for Muscle GrowthFor those seeking muscle growth without the risks associated with anabolic steroids, natural alternatives are a safer and effective option. Here are some of the top natural steroids for muscle growth:Creatine: Found naturally in foods like fish and meat, creatine helps increase muscle strength and endurance, making it a popular choice among athletes.Ashwagandha: This herb, used in Ayurvedic medicine, is known for its ability to promote muscle growth and enhance strength.Tribulus Terrestris: A plant extract that boosts testosterone levels, Tribulus Terrestris supports muscle growth and overall physical performance.D-Aspartic Acid (DAA): An amino acid that increases testosterone levels, DAA is essential for promoting muscle growth and strength.Vitamin D: An essential nutrient, Vitamin D plays a crucial role in muscle growth and strength, supporting overall health and performance.These natural supplements provide a safer alternative to anabolic steroids, helping to build muscle mass and improve strength without the associated health risks.Herbal Supplements for Muscle GrowthIn addition to natural steroids, several herbal supplements can aid in muscle growth and overall fitness. Here are some effective options:Ginseng: Known for its energy-boosting properties, ginseng helps increase endurance and enhance athletic performance.Fenugreek: This herb is known to increase testosterone levels, promoting muscle growth and strength.Safed Musli: Used in traditional Indian medicine, Safed Musli supports muscle growth and enhances physical strength.5-Alpha-Hydroxy-Laxogenin: A plant extract that promotes muscle growth and strength, 5-alpha-hydroxy-laxogenin is a popular choice among bodybuilders.While these herbal supplements can significantly aid muscle growth, they should be used alongside a healthy diet and regular exercise for the best results. Always consult with a healthcare professional before starting any new supplement to ensure it aligns with your health and fitness goals.Understanding Anabolic SteroidsAnabolic steroids are synthetic hormones designed to mimic the effects of the male sex hormone testosterone. These substances are widely used to promote muscle growth, increase strength, and enhance athletic performance. Available in various forms such as oral tablets, injectable solutions, and creams, anabolic steroids work by increasing protein synthesis, which helps build muscle mass and repair damaged tissues.However, anabolic steroids are classified as controlled substances due to their high potential for misuse and abuse. Using anabolic steroids without a medical prescription is illegal and can lead to severe health consequences. Many athletes and bodybuilders misuse anabolic steroids to gain a competitive edge, but this practice can result in significant health problems, including liver damage, high blood pressure, and cardiovascular disease. The risks associated with anabolic androgenic steroid use far outweigh the benefits, making it crucial to consider safer alternatives.Risks of Anabolic Steroid MisuseMisusing anabolic steroids can lead to a range of serious health problems, including:Liver Damage and Liver Cancer: Anabolic steroids can cause severe liver damage, leading to conditions such as liver cancer.High Blood Pressure and Cardiovascular Disease: Steroid use can raise blood pressure, increasing the risk of cardiovascular diseases, including heart attacks and strokes.Aggressive Behavior and Mood Swings: Known as "roid rage," anabolic steroids can cause significant changes in mood and behavior.Acne and Skin Problems: Steroid use can exacerbate skin conditions, leading to severe acne and other skin issues.Hair Loss and Male Pattern Baldness: Anabolic steroids can accelerate hair loss and contribute to male pattern baldness.Gynecomastia: The development of breast tissue in men, a condition known as gynecomastia, can occur with steroid misuse.Infertility and Sexual Dysfunction: Long-term use of anabolic steroids can lead to infertility and other sexual health issues.Additionally, long-term use of anabolic steroids can lead to dependence and addiction. When individuals stop using anabolic steroids, they may experience withdrawal symptoms such as depression, anxiety, and insomnia. The potential for these severe health risks underscores the importance of avoiding anabolic steroid misuse.Contact InformationTony StevensLabmeeting[email protected]4152229090SOURCE: Labmeeting

27 Jun 2023

·endpts.com

Almost 40 years after an adcomm's warning: FDA and sponsors withdraw approval for anabolic steroid

The FDA announced that it’s withdrawing the approval of Gemini Laboratories’ anabolic steroid Oxandrin (oxandrolone) and four generic versions, a decades-old treatment once indicated for the relief of bone pain linked to osteoporosis. Oxandrin first won FDA approval in 1964. Then, in 1984, an FDA advisory committee unanimously concluded that there was no evidence of efficacy for the tablets, and so Tuesday’s announcement is a sign of how long it can take for the agency and sponsors to fully withdraw a drug’s approval, even with safety concerns. Unlock this article instantly, along with access to limited free monthly articles and our suite of newsletters

Drug ApprovalAccelerated Approval

100 Deals associated with Oxandrolone

External Link

KEGG	Wiki	ATC	Drug Bank
D00462	Oxandrolone	A14AA08	DB00621

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Ostealgia	United States	Gemini Laboratories LLC	21 Jul 1964
Weight Loss	United States	Gemini Laboratories LLC	21 Jul 1964

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2021	Not Applicable	Kidney Tubular Necrosis, Acute	-	Oxandrolone	tbdtbvlwbn(frngffhanj) = Labwork revealed AGMA and ketosis (CO2 17.2mmol/L, AG 24.4 mmol/L, β - hydroxybutyrate 48.97 mg/dL) ftyfcfzpyf (giptjwpwsn ) View more	-	27 Oct 2021
NCT00348946 (CTgov)	Phase 2	Klinefelter Syndrome	93	oxandrolone (Oxandrolone)	rkgaguxydr(ccoxpiyfcj) = ahafzaylos zlkmtkgxwt (iagzknzuif, 1) View more	-	08 Jul 2021
				placebo (Placebo)	rkgaguxydr(ccoxpiyfcj) = aylkdskgic zlkmtkgxwt (iagzknzuif, 1) View more
NCT00348946 (Pubmed \| J Clin Endocrinol Metab)	Phase 2	Klinefelter Syndrome	93	Oxandrolone	gxtzjscfwj(qkbvqzumpt): OR = 20.5 (95% CI, 6.5 - 77.8) View more	-	01 Sep 2018
				Placebo
AHNS2018	Not Applicable	Cachexia \| Head and Neck Neoplasms	-	Oxandrolone	sxwldfwjbg(vbdbrkujxv) = uzuadgalnv gyqhnutyou (eisscczviw )	Positive	18 Apr 2018
NCT00675714 (Pubmed \| J Burn Care Res)	Phase 2/3	Burns	54	Oxandrolone	fpomxjluty(lyofiamzgc) = hqamvcvtqv rzkvgcerhb (ozyjxbyulm )	-	01 Jan 2016
				Oxandrolone arm	fpomxjluty(lyofiamzgc) = apamhahhkp rzkvgcerhb (ozyjxbyulm )
ACTRN12615000191594 (Pubmed \| Med Sci Sports Exerc)	Not Applicable	-	-	Oxandrolone	zntajdsqxc(lpjvxjuddu) = gkxzzrodtu uwjqojcxqp (tzychedvfm, -1.6 to -0.4) View more	Positive	01 Nov 2015
ESPE2015	Not Applicable	Turner Syndrome	106	Oxandrolone	iltlzefwpm(lvzwzkernd) = rijbzsooen lmenicasrv (ebpwtphilp, 1.6 - 6.6)	Positive	01 Oct 2015
NCT00101361 (Pubmed \| Ann Intern Med) Manual	Phase 3	Pressure Ulcer	212	OxandroloneOxandrolone 20 mg/d	kvdonhrtcn(ctnjgpudhd) = idajhrqpad lmswisozrg (fpylglrxzt, 16.0 - 32.1) View more	Negative	21 May 2013
				Placebo	kvdonhrtcn(ctnjgpudhd) = vvdkaqemmh lmswisozrg (fpylglrxzt, 21.0 - 38.6) View more
ISRCTN50343149 (Pubmed)	Not Applicable	Turner Syndrome	106	Oxandrolone	rbbyrqfavy(shteekqmlr) = hacgvodoiz pmpdllmsex (krswjnnxqa, 1.9 - 7.2)	-	14 Apr 2011
				Ethinylestradiol	rbbyrqfavy(shteekqmlr) = drdexukaud pmpdllmsex (krswjnnxqa, 0.0 - 7.5)
ASCO2008 Manual	Phase 3	Solid tumor	155	oxandrolone 10mg bid	wcrodwzuci(rbazobvmys) = bniukrfgmy peromecyqa (baqbzlwkrw ) View more	Positive	20 May 2008
				megestrol acetate 800mg qd	wcrodwzuci(rbazobvmys) = kmmqkwkjoy peromecyqa (baqbzlwkrw ) View more

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