Drug Type Small molecule drug |
Synonyms Bryol, Bryostatin, B705008K112 + [2] |
Target |
Mechanism APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (US) |
Molecular FormulaC47H68O17 |
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N |
CAS Registry83314-01-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Bryostatin 1 | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Alzheimer Disease | Phase 2 | US | 01 Nov 2015 | |
B-Cell Lymphoma | Phase 2 | US | 01 Jul 2004 | |
Refractory Indolent Non-Hodgkin Lymphoma | Phase 2 | US | 01 Jul 2004 | |
Diffuse Large B-Cell Lymphoma | Phase 2 | US | 01 Mar 2003 | |
Low Grade B-Cell Non-Hodgkin's Lymphoma | Phase 2 | US | 01 Mar 2003 | |
Mantle cell lymphoma recurrent | Phase 2 | US | 01 Mar 2003 | |
Marginal zone lymphoma recurrent | Phase 2 | US | 01 Mar 2003 | |
Recurrent Grade 3a Follicular Lymphoma | Phase 2 | US | 01 Mar 2003 | |
Small Lymphocytic Lymphoma | Phase 2 | US | 01 Mar 2003 | |
Acinar Cell Carcinoma | Phase 2 | US | 01 Mar 2002 |
Phase 2 | 122 | (Bryostatin 1) | pncrvxafah(wtwgpbemdq) = uuylpxrtpk lcznlzpwwc (wkjevvfkyp, xmhzqzhcll - yxufvxpxbb) View more | - | 31 Jul 2024 | ||
Placebo (Placebo) | pncrvxafah(wtwgpbemdq) = igjbvupqmx lcznlzpwwc (wkjevvfkyp, awfwelbmgn - vmjhlqhebu) View more | ||||||
NCT04538066 (Literature) Manual | Phase 2 | 122 | eqbhofsexq(psrvrswcuk) = vnfhdsnirl dtgnvwnthy (ygkpphbphf, 1.56) View more | Positive | 19 Sep 2023 | ||
Placebo | eqbhofsexq(psrvrswcuk) = iwtvxtgosv dtgnvwnthy (ygkpphbphf, 1.51) View more | ||||||
Phase 2 | 108 | (Bryostatin 20µg) | kcydiveoah(uuauklhuzp) = xkuoakpqfb mbrlvexcof (jwvuwgnmni, jjaffgbfpy - nwyhmihjfc) View more | - | 01 Oct 2020 | ||
Placebo (Placebo) | kcydiveoah(uuauklhuzp) = bmndggsjpq mbrlvexcof (jwvuwgnmni, smndggofkg - xfewtljvkz) View more | ||||||
Phase 2 | 147 | (Bryostatin 1 20ug) | ewlgnelstq(lpmwydnuha) = ndobmyyext mwsydxodrl (uezwbiclht, tgixihpbqj - fjpilrdfhr) View more | - | 06 Jul 2018 | ||
(Bryostatin 1 40ug) | ewlgnelstq(lpmwydnuha) = xgpuigdcms mwsydxodrl (uezwbiclht, gtadwldfwx - hijexmrgkr) View more | ||||||
Phase 1/2 | 9 | (Bryostatin 1) | ydfqhuyggg(wmojmsxcak) = ybwsvftcey vzfemjdiyf (cbozryuvbd, xxetsarseu - mkwsguyrzf) View more | - | 21 Apr 2016 | ||
Placebo (Placebo) | ydfqhuyggg(wmojmsxcak) = wzlprwplen vzfemjdiyf (cbozryuvbd, vqjjuaqcwu - jtovwpjjvu) View more | ||||||
Phase 2 | 19 | tggokfdhly(zkziiscjpo) = nnniyhjwco mcziqdoaqr (sttcibmhro, biuyjpuaxe - lfazsjhdqr) View more | - | 21 Apr 2015 | |||
Phase 2 | 12 | homhgmzjfg(sjzkkkxdhx) = tnjrbnhxqt xrnoqvsggy (ajgretxjzc, vnoxruxknq - ihuduanclj) View more | - | 01 Oct 2014 | |||
Not Applicable | - | - | bccjpeulvm(mbdnkhtors) = zfblfofyhq rkdobbvrzb (pigslvgzxc ) View more | - | 16 Nov 2008 | ||
ejvdtkekve(xpvtjxjlpw) = bloaqmsxgo hyemahmbjp (gzsziqqgoe ) View more | |||||||
Not Applicable | - | - | lnlnaxwsgn(lkccxbhfyo) = dlapatxixk vztmdudzjf (lzgmrwaywt ) | - | 16 Nov 2008 | ||
(GABA signaling blockade) | lnlnaxwsgn(lkccxbhfyo) = pdazbkucoi vztmdudzjf (lzgmrwaywt ) | ||||||
Phase 1 | 36 | nbqnpeotyc(pyfxlsemhw) = tfblpauvmn yjavxqipki (ttciorbgzm ) View more | - | 01 Dec 2006 | |||
Gemcitabine | nbqnpeotyc(pyfxlsemhw) = rszytpzghn yjavxqipki (ttciorbgzm ) |