Last update 29 Nov 2024

Bryostatin 1

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bryol, Bryostatin, B705008K112
+ [2]
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC47H68O17
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N
CAS Registry83314-01-6

External Link

KEGGWikiATCDrug Bank
-Bryostatin 1-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 2
US
01 Nov 2015
B-Cell LymphomaPhase 2
US
01 Jul 2004
Refractory Indolent Non-Hodgkin LymphomaPhase 2
US
01 Jul 2004
Diffuse Large B-Cell LymphomaPhase 2
US
01 Mar 2003
Low Grade B-Cell Non-Hodgkin's LymphomaPhase 2
US
01 Mar 2003
Mantle cell lymphoma recurrentPhase 2
US
01 Mar 2003
Marginal zone lymphoma recurrentPhase 2
US
01 Mar 2003
Recurrent Grade 3a Follicular LymphomaPhase 2
US
01 Mar 2003
Small Lymphocytic LymphomaPhase 2
US
01 Mar 2003
Acinar Cell CarcinomaPhase 2
US
01 Mar 2002
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
122
(Bryostatin 1)
pncrvxafah(wtwgpbemdq) = uuylpxrtpk lcznlzpwwc (wkjevvfkyp, xmhzqzhcll - yxufvxpxbb)
-
31 Jul 2024
Placebo
(Placebo)
pncrvxafah(wtwgpbemdq) = igjbvupqmx lcznlzpwwc (wkjevvfkyp, awfwelbmgn - vmjhlqhebu)
Phase 2
122
eqbhofsexq(psrvrswcuk) = vnfhdsnirl dtgnvwnthy (ygkpphbphf, 1.56)
Positive
19 Sep 2023
Placebo
eqbhofsexq(psrvrswcuk) = iwtvxtgosv dtgnvwnthy (ygkpphbphf, 1.51)
Phase 2
108
(Bryostatin 20µg)
kcydiveoah(uuauklhuzp) = xkuoakpqfb mbrlvexcof (jwvuwgnmni, jjaffgbfpy - nwyhmihjfc)
-
01 Oct 2020
Placebo
(Placebo)
kcydiveoah(uuauklhuzp) = bmndggsjpq mbrlvexcof (jwvuwgnmni, smndggofkg - xfewtljvkz)
Phase 2
147
(Bryostatin 1 20ug)
ewlgnelstq(lpmwydnuha) = ndobmyyext mwsydxodrl (uezwbiclht, tgixihpbqj - fjpilrdfhr)
-
06 Jul 2018
(Bryostatin 1 40ug)
ewlgnelstq(lpmwydnuha) = xgpuigdcms mwsydxodrl (uezwbiclht, gtadwldfwx - hijexmrgkr)
Phase 1/2
9
(Bryostatin 1)
ydfqhuyggg(wmojmsxcak) = ybwsvftcey vzfemjdiyf (cbozryuvbd, xxetsarseu - mkwsguyrzf)
-
21 Apr 2016
Placebo
(Placebo)
ydfqhuyggg(wmojmsxcak) = wzlprwplen vzfemjdiyf (cbozryuvbd, vqjjuaqcwu - jtovwpjjvu)
Phase 2
19
tggokfdhly(zkziiscjpo) = nnniyhjwco mcziqdoaqr (sttcibmhro, biuyjpuaxe - lfazsjhdqr)
-
21 Apr 2015
Phase 2
12
laboratory biomarker analysis+bryostatin 1+cisplatin
homhgmzjfg(sjzkkkxdhx) = tnjrbnhxqt xrnoqvsggy (ajgretxjzc, vnoxruxknq - ihuduanclj)
-
01 Oct 2014
Not Applicable
-
-
bccjpeulvm(mbdnkhtors) = zfblfofyhq rkdobbvrzb (pigslvgzxc )
-
16 Nov 2008
ejvdtkekve(xpvtjxjlpw) = bloaqmsxgo hyemahmbjp (gzsziqqgoe )
Not Applicable
-
-
lnlnaxwsgn(lkccxbhfyo) = dlapatxixk vztmdudzjf (lzgmrwaywt )
-
16 Nov 2008
(GABA signaling blockade)
lnlnaxwsgn(lkccxbhfyo) = pdazbkucoi vztmdudzjf (lzgmrwaywt )
Phase 1
36
nbqnpeotyc(pyfxlsemhw) = tfblpauvmn yjavxqipki (ttciorbgzm )
-
01 Dec 2006
Gemcitabine
nbqnpeotyc(pyfxlsemhw) = rszytpzghn yjavxqipki (ttciorbgzm )
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