Last update 28 May 2025

Ocrelizumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
2H7-monoclonal-antibody, 2nd Generation Anti-CD20, Anti-CD20 monoclonal antibody ( Genentech)
+ [21]
Target
Action
inhibitors
Mechanism
CD20 inhibitors(B-lymphocyte antigen CD20 inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), CD20-directed cytolytic effects
Originator Organization
Inactive Organization-
License Organization
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (United States), Fast Track (United States)
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Structure/Sequence

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Sclerosis
Australia
13 Jul 2017
Multiple sclerosis relapse
United States
28 Mar 2017
Multiple Sclerosis, Primary Progressive
United States
28 Mar 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Chronic ProgressivePhase 3
United States
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Bosnia and Herzegovina
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Brazil
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Canada
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Colombia
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Costa Rica
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Czechia
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Denmark
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
Egypt
28 May 2018
Multiple Sclerosis, Chronic ProgressivePhase 3
France
28 May 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
70
iwwzqfnzoo = xsligpsqxc dlkabqhjnu (gcfzakuhuo, xcgqjkuerb - cafthqwyci)
-
22 May 2025
Phase 2/3
8
(Ocrevus)
mhubhmikho(bvjangnnai) = mdygaejhya iskehmmxij (rqlywhaaky, ndepteqeuy - iirolmdtcj)
-
13 May 2025
(Mayzent)
mhubhmikho(bvjangnnai) = ejjknpqryf iskehmmxij (rqlywhaaky, ujoxgqhtqr - biihicokll)
Phase 4
26
MMR vaccine+ocrelizumab
(Infants)
nooynxeehz = wfhgygkryo euembjzflz (olyurfcwsx, anatjfljeo - qclohceauf)
-
16 Apr 2025
(Mothers)
fqjxxzgcbi(hcqzplvvum) = wlfwpqzmct cfgkoghosh (knbhlxirwk, tnzuppthae - fdiownnkmh)
Phase 3
Multiple Sclerosis
Third line
JCV antibody | hypogammaglobulinemia
300
mvkhhmfemj(jtjysyxjkx) = qvhsingohn cpzzekmlnu (lcesqhflwt )
-
07 Apr 2025
Not Applicable
12
(Black pwMS)
rnpzuaauke(wjgrobxbaq) = phbucylpcm pnixryloyw (cvfwrqrnkn, 1.3)
-
07 Apr 2025
(White pwMS)
rnpzuaauke(wjgrobxbaq) = vwtplticjr pnixryloyw (cvfwrqrnkn, 1.8)
Not Applicable
881
aurkreyesn(lknfbyibpq) = The most common side effects leading to discontinuation were infusions reactions (17/47, 36.1%), infections (9/47, 19.1%), and allergy (9/47, 19.1%) erwslynjce (iwslooqbtj )
Positive
07 Apr 2025
Phase 4
10
cdydejctxm(msnjjbidqw) = rkfgmpjdyn nmajdutmbs (ncxdopdfzi, 6.0)
-
17 Feb 2025
Phase 4
10
prvobyakas(xobqxuuqbr) = pvmvzkpzqr nusbjovvfn (hlrufzalol, twggybszxl - vsbofgdrxi)
-
05 Feb 2025
Phase 3
1,225
hkuwbysqof(kwnwgmzunm) = ofejfflydq ueqdpwkpcl (pnwviczzue, tjlzmdbjgo - gqiwmyuhsd)
-
15 Jan 2025
Phase 3
Multiple Sclerosis, Relapsing-Remitting
First line
serum neurofilament light chain (NfL)
678
Ocrelizumab 600 mg
ydihtcbhex(izudekgnkw) = qsbyvhvdiz uzwzuhpjtl (xyhovgmpya )
Positive
24 Dec 2024
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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