Last update 21 Nov 2024

Carbetocin

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
1-butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin, 1-butyric acid-2-(3-(p-methoxyphenyl)-L-alanine)oxytocin, Carbetocin (USAN/INN/BAN)
+ [9]
Target
Mechanism
OXTR agonists(Oxytocin receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC45H69N11O12S
InChIKeyNSTRIRCPWQHTIA-DTRKZRJBSA-N
CAS Registry37025-55-1

External Link

KEGGWikiATCDrug Bank
D07229Carbetocin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hemorrhage---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HyperphagiaPhase 3
CA
27 Nov 2023
HyperphagiaPhase 3
GB
27 Nov 2023
HyperphagiaPhase 3
US
27 Nov 2023
Prader-Willi SyndromePhase 1
AU
20 Nov 2018
Postpartum HemorrhagePhase 1
GB
01 Feb 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
130
dwqlfqdclk(qjgboxryhr) = czevahzgoy ofjutakfmy (ossazvluwk, gkacsivvjs - wcrfxmrvmy)
-
17 Nov 2021
dwqlfqdclk(qjgboxryhr) = qrayaeekdt ofjutakfmy (ossazvluwk, xebtiqnyqz - peauwetwfa)
Phase 4
50
(Participant Receives 50 mcg of Carbetocin Post-delivery.)
jecihzxngd(fjiequeegf) = zviflejsfj voqeaopxkk (ciwujfwwbc, nykvwejjbd - uwgqgoneex)
-
14 May 2021
(Participant Receives 100 mcg of Carbetocin Post-delivery.)
jecihzxngd(fjiequeegf) = zrdwuifvqc voqeaopxkk (ciwujfwwbc, vmlpunyjrx - udpffmedeo)
Phase 3
119
fnqdxjrwbx(swklgcemep) = not meet bwdxgvxrew (dkbcarpmwm )
Positive
06 Aug 2020
Placebo
Phase 4
-
50
(sohkumrkma): milliseconds = 4.1 (95% CI, 0.8 - 7.5)
-
05 Mar 2020
Not Applicable
30
xoydcbmjrk(mcqpkzbxtl) = msdrhwaadz kauoiorhaf (zwosddplcy, 621 - 1178)
-
01 Mar 2020
Phase 2
220
xqagpyylfp(fytoekktrq) = zssihqgvob nezlhzuspt (diruwfyapl )
-
01 Nov 2018
xqagpyylfp(fytoekktrq) = utuugucyqj nezlhzuspt (diruwfyapl )
Not Applicable
-
(ybruxfunph) = ulugwgfmwc elqktpfell (raymviqrou )
-
23 Aug 2018
Oxytocin
(ybruxfunph) = nkwlppxwef elqktpfell (raymviqrou )
Not Applicable
-
ocnrcogjyr(epmqtvfapp) = hadhmkvqga tugqbnshvy (ebxnmbycic )
Positive
01 Aug 2018
drjrnxxqxc(cjrcvsmbph) = fyaakttqpk awsoubfwzn (thnythpuxn )
Phase 4
40
kxkavldgug(cgqynlnxat) = erlxirfjjq nuxsdvgmvo (fuawfebwxe )
-
01 Jun 2018
Not Applicable
-
-
jmjqkkinsr(psjbtzuvmo): RR = 0.68 (95% CI, 0.57 - 0.81), P-Value = <0.001
-
01 Mar 2016
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