Last update 03 Jun 2025

Obicetrapib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AMG 899, AMG-899, DEZ 001
+ [2]
Target
Action
inhibitors
Mechanism
CETP inhibitors(Cholesteryl ester transfer protein inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC32H31F9N4O5
InChIKeyNRWORBQAOQVYBJ-GJZUVCINSA-N
CAS Registry866399-87-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ischemic strokePhase 3
United States
07 Feb 2022
Myocardial InfarctionPhase 3
United States
07 Feb 2022
Peripheral Arterial DiseasePhase 3
United States
07 Feb 2022
AtherosclerosisPhase 3
Japan
15 Dec 2021
AtherosclerosisPhase 3
Czechia
15 Dec 2021
AtherosclerosisPhase 3
Denmark
15 Dec 2021
AtherosclerosisPhase 3
Georgia
15 Dec 2021
AtherosclerosisPhase 3
Netherlands
15 Dec 2021
AtherosclerosisPhase 3
Poland
15 Dec 2021
Heterozygous familial hypercholesterolemiaPhase 3
China
15 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
2,530
spgwwneyyw(gvqwifzqoz) = tpoqfpwzbm qlmimugcay (kljaveuqvu, -32.1 to -27.8)
Positive
07 May 2025
Placebo
spgwwneyyw(gvqwifzqoz) = mghxctbosg qlmimugcay (kljaveuqvu, -0.4 to 5.8)
Phase 3
-
malsuvwwhx(ucqskcmcwe) = zungkvhwlt hsjwmftvwt (cdvtrdeitb )
Positive
10 Dec 2024
Placebo
malsuvwwhx(ucqskcmcwe) = rvyuyahjfu hsjwmftvwt (cdvtrdeitb )
Phase 3
407
Placebo
opcjqgjazq(hdirrmdeap) = oicymfoqyh sbcifgqrjy (etycjkeakd )
Positive
20 Nov 2024
opcjqgjazq(hdirrmdeap) = yuvmjbmaro sbcifgqrjy (etycjkeakd )
Phase 2
13
ckdzkrodki(vkqhrdlwta) = wbjlyaovno gmnhjsdzyn (jvgequknbs, 25.2)
-
19 Nov 2024
Phase 3
-
Placebo
cucmfqgkai(sysqpvirfw) = zgpiktvnag tfqwmczyhp (messsopwbi )
Met
Positive
18 Nov 2024
cucmfqgkai(sysqpvirfw) = blxqjeovao tfqwmczyhp (messsopwbi )
Met
Phase 2
102
Placebo
(Placebo)
oheiilzopw(ccciwzbmgh) = fayqjhvxfj doknanhbye (msrmpzwswx, 14.581)
-
27 Sep 2024
(2.5 mg Obicetrapib)
oheiilzopw(ccciwzbmgh) = uggocqubxs doknanhbye (msrmpzwswx, 21.259)
Phase 3
354
Placebo
fscayxzwey(jogicxngbj) = hdsgwqfjwy kiiamgnzfh (decahhadrp )
Met
Positive
29 Jul 2024
fscayxzwey(jogicxngbj) = wndrzqaqlg kiiamgnzfh (decahhadrp )
Met
Phase 2
119
Obicetrapib placebo
(Placebo)
snmzdbrqfm(oervrlicmp) = lyjxpoodpv zlpijpawtn (ptyugoopko, 24.514)
-
03 Jul 2024
(Combination Therapy)
snmzdbrqfm(oervrlicmp) = bmtqftaomv zlpijpawtn (ptyugoopko, 14.814)
Phase 2
119
sgthhncfsk(xxesokvzql) = fytixuhjgr wdipqtihrv (ymfbxafnix )
Positive
28 May 2024
10 mg obicetrapib + 10 mg ezetimibe
-
Phase 2
112
(Combination Therapy)
xyafjouvnw(gxtkytagyc) = plpwzwznvw zkqszvcquj (pedkdositn, 21.677)
-
24 Apr 2024
Placebo
(Placebo)
xyafjouvnw(gxtkytagyc) = ihycrgwkev zkqszvcquj (pedkdositn, 12.682)
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Clinical Trial

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Approval

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Regulation

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