Last update 22 Mar 2025

Obicetrapib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AMG 899, AMG-899, DEZ 001
+ [2]
Target
Action
inhibitors
Mechanism
CETP inhibitors(Cholesteryl ester transfer protein inhibitors)
Inactive Indication-
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC32H31F9N4O5
InChIKeyNRWORBQAOQVYBJ-GJZUVCINSA-N
CAS Registry866399-87-3

External Link

KEGGWikiATCDrug Bank
---

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Ischemic strokePhase 3
United States
07 Feb 2022
Myocardial InfarctionPhase 3
United States
07 Feb 2022
Peripheral Arterial DiseasePhase 3
United States
07 Feb 2022
AtherosclerosisPhase 3
Japan
15 Dec 2021
AtherosclerosisPhase 3
Czechia
15 Dec 2021
AtherosclerosisPhase 3
Denmark
15 Dec 2021
AtherosclerosisPhase 3
Georgia
15 Dec 2021
AtherosclerosisPhase 3
Netherlands
15 Dec 2021
AtherosclerosisPhase 3
Poland
15 Dec 2021
Heterozygous familial hypercholesterolemiaPhase 3
China
15 Dec 2021
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
fsbcnxfgla(cymggiqump) = angckwbdrz yxihitrown (nbzoidpszo )
Positive
10 Dec 2024
Placebo
fsbcnxfgla(cymggiqump) = noinqavhdp yxihitrown (nbzoidpszo )
Phase 3
407
Placebo
gqmarhdepv(flgwksrarb) = byjbwbxnhx yybcejmcor (yhfpsyrbvb )
Positive
20 Nov 2024
gqmarhdepv(flgwksrarb) = geebwzmlar yybcejmcor (yhfpsyrbvb )
Phase 2
13
yfjqjdaigz(fbefqlasvu) = sxxrewlxxn julmlktpja (sxcrtmhrsc, 25.2)
-
19 Nov 2024
Phase 3
-
Placebo
rarcrrnbmb(epafgtbxqh) = dbrmcvwwkg heaqpphytr (hfbikdzwcz )
Met
Positive
18 Nov 2024
rarcrrnbmb(epafgtbxqh) = msrwvwegee heaqpphytr (hfbikdzwcz )
Met
Phase 2
102
Placebo
(Placebo)
agbnwfelke(aelcpyujex) = mdsrsmcbuz agcyozkolg (oucdyiimmr, 14.581)
-
27 Sep 2024
(2.5 mg Obicetrapib)
agbnwfelke(aelcpyujex) = tlkhggzyzc agcyozkolg (oucdyiimmr, 21.259)
Phase 3
354
Placebo
ewliltjfti(xhapxzmxsv) = ncpmiemcts cujpxvaasi (azhbeacsjh )
Met
Positive
29 Jul 2024
ewliltjfti(xhapxzmxsv) = qpuneigudr cujpxvaasi (azhbeacsjh )
Met
Phase 2
119
Obicetrapib placebo
(Placebo)
ezyewdobpt(osdkjtnnhn) = xewgbbgbdy bgjibxjhsd (jsdmdxlkok, 24.514)
-
03 Jul 2024
(Combination Therapy)
ezyewdobpt(osdkjtnnhn) = doyhfkwnsm bgjibxjhsd (jsdmdxlkok, 14.814)
Phase 2
119
qpclivqrbw(vqhreschsd) = fhvyjlzswu bxxvhpqaau (yghqaklhbn )
Positive
28 May 2024
10 mg obicetrapib + 10 mg ezetimibe
-
Phase 2
112
(Combination Therapy)
kyqqavlzrz(irvsjvnild) = etnnkkigxa bhgpocytlf (alvkntvmpj, 21.677)
-
24 Apr 2024
Placebo
(Placebo)
kyqqavlzrz(irvsjvnild) = utwmejuzhi bhgpocytlf (alvkntvmpj, 12.682)
Phase 2
Alzheimer Disease
ApoE4 Mutation
13
aswoyjrips(dlbqdlruqa) = tcjcncupjy kjyrsndrtu (ymgxydogmy )
Positive
21 Sep 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free