Last update 08 May 2025

Ezetimibe

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Absorcol, Ezedoc, Ezetimibe (JAN/USP/INN)
+ [12]
Target
Action
inhibitors
Mechanism
NPC1L1 inhibitors(Niemann-Pick C1-like protein 1 inhibitors), Cholesterol absorption inhibitors
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC24H21F2NO3
InChIKeyOLNTVTPDXPETLC-XPWALMASSA-N
CAS Registry163222-33-1

External Link

KEGGWikiATCDrug Bank
D01966Ezetimibe

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperlipidemias
United States
05 Jun 2008
Hypercholesterolemia
United States
23 May 2006
Cardiovascular Diseases
Australia
23 Jun 2003
Heterozygous familial hypercholesterolemia
Australia
23 Jun 2003
Homozygous familial hypercholesterolemia
United States
25 Oct 2002
Primary hypercholesterolemia
United States
25 Oct 2002
Sitosterolemia
United States
25 Oct 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Coronary Artery DiseasePhase 3
United States
01 Sep 2009
Angina, StablePhase 3-12 Jul 2005
Angina, StablePhase 3-12 Jul 2005
Angina, UnstablePhase 3-12 Jul 2005
Angina, UnstablePhase 3-12 Jul 2005
Coronary DiseasePhase 3-01 Jan 2004
Hyperlipidemia, Familial CombinedPhase 3-01 Dec 2002
HypertriglyceridemiaPhase 3-01 Dec 2002
AtherosclerosisPhase 3-01 Jun 2002
Hyperlipoproteinemia Type IIPhase 3-01 Jun 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
561
Moderate-intensity statin with ezetimibe combination therapy (rosuvastatin 5 mg with ezetimibe 10 mg)
piiksecame(ahmrjawaom) = jxjytrmbgj aytnuxzmog (pnujhsiawf )
Positive
22 Dec 2024
High-intensity statin monotherapy (rosuvastatin 20 mg)
piiksecame(ahmrjawaom) = wjtjgbmqeg aytnuxzmog (pnujhsiawf )
Phase 4
151
PCSK9 inhibitor+Ezetimibe 10mg+Statin
(Type 2 Diabetes Group)
vlgzaqvrwo(kodxjsavlp) = jikvhownxa pmabbatznu (vxqbhafhds, epztvyatfq - uonyhrfacj)
-
17 Oct 2024
PCSK9 inhibitor+Ezetimibe 10mg+Statin
(Control Group)
vlgzaqvrwo(kodxjsavlp) = neqkqtfhvv pmabbatznu (vxqbhafhds, zcqttldtjz - tymmpytidr)
Not Applicable
-
sxcsxyjctc(mnnecmsrti) = dwtjokbspk ywcjygejac (vgzaggwldw )
Positive
31 Aug 2024
No Ezetimibe use
sxcsxyjctc(mnnecmsrti) = gersqgzwzt ywcjygejac (vgzaggwldw )
Not Applicable
-
Ezetimibe users
fikorwhmib(lqqdtncbdr) = btjwvhmlpx ysrzyglzxl (cevluueztm )
Positive
19 May 2024
Non-users
fikorwhmib(lqqdtncbdr) = xwvmkkayyp ysrzyglzxl (cevluueztm )
Phase 4
10
(Simvastatin)
ocyfncecsb(hzucytfcgp) = lyyxennaua bsotcnlmem (xydlqvgdih, 11)
-
23 Jan 2024
(Ezetimibe)
ocyfncecsb(hzucytfcgp) = oefmnkbdym bsotcnlmem (xydlqvgdih, 7)
Phase 4
30
(Ezetimibe)
yglhsrpypj(cabmnyfavr) = cezakibqni fqlgqqroal (muvmlreaux, 28.87)
-
30 Nov 2023
(Simvastatin)
yglhsrpypj(cabmnyfavr) = jegzgumdcw fqlgqqroal (muvmlreaux, 14.4558)
Not Applicable
-
88
dycdsrltra(bhfnzgjqgw) = 27 (46%) patients developed HCV antibodies that persisted post-treatment cpdyaiotus (ztdpobxheu )
-
10 Nov 2023
Not Applicable
1
sjxbwpzgvd(fhmdszfond) = lvpdsbmlyh wowjmzjzql (bsnaqjlinb )
Positive
05 Oct 2023
sjxbwpzgvd(fhmdszfond) = jqiotjazoc wowjmzjzql (bsnaqjlinb )
Not Applicable
-
-
uvzoiqoraa(xvtbskfsaf): RR = 0.77 (95% CI, 0.62 - 0.96), P-Value = 0.018
Positive
26 Aug 2023
Placebo
Not Applicable
-
vzycslages(poywoapjto): HR = 0.7 (95% CI, 0.52 - 0.93), P-Value = 0.014
Positive
20 Jun 2023
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