Vestibular migraine (VM) is one of the most common vestibular disorders, affecting 1.0% to 2.7% of the general population1, 7% of patients with definite migranous vertigo in dizziness clinics2, as well as 10.3% of VM patients in headache clinics3; 65% to 85% of VM patients are female1. Despite the relative prevalence of vestibular migraine, evidence-based medicine remains scarce. Two Cochrane reviews published in 2023 found that there is almost no evidence to support the use of medications for the acute treatment or preventive treatment of VM4,5.
Calcitonin gene-related peptide (CGRP) has been established as an excellent target for the treatment of migraine. Animal studies suggest a link between CGRP and vestibular disorders. A prospective observational cohort study found that monoclonal antibodies targeting CGRP receptors and ligands were very effective for vestibular migraine (VM), with 90% of participants experiencing at least a 50% reduction in vertigo attacks6. A small-scale prospective randomized controlled trial showed that a monoclonal antibody targeting a CGRP ligand significantly reduced the number of dizziness days per month in VM patients compared to placebo7. The efficacy of CGRP small molecule antagonists for the preventive and acute treatment of migraines has been widely recognized8,9. Therefore, we speculate that Rimegepant is effective for the preventive and acute treatment of vestibular migraine.
By focusing on a large sample RCT, our study can offer new evidence-based treatment options for patients with vestibular migraine. This is crucial, as many patients with vestibular migraine may not respond well to conventional migraine treatments. Our findings could guide clinicians in choosing more effective therapeutic strategies.
Specifically in acute treatment of vestibular migraine, triptans have failed to show superiority when compared to placebo in treatment vestibular migraine symptoms10. Prochlorperazine, a vestibular sedative, is widely used for acute treatment of vestibular migraine but is known to chronify symptoms11. Should rimegepant demonstrate superiority to placebo in this study, rimegepant could potentially become the first-line treatment for vestibular migraine across the world.

Start Date01 Jun 2025

Sponsor / Collaborator

Second Affiliated Hospital Zhejiang University College of

NCT06985342

/ Not yet recruitingPhase 4IIT

A Prospective, Open-Label Study Examining the Use of Rimegepant ODT 75 mg or Zavegepant Nasal Spray 10 mg for Acute Treatment of Migraine in the Emergency Department Setting

This study evaluates the effectiveness of rimegepant 75 mg orally disintegrating tablet (ODT) single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments during Emergency Department (ED) encounters. Although these two calcitonin gene-related peptide receptors (CGRP) receptor antagonists are FDA-approved for the indication of acute migraine treatment, past studies have been limited to the outpatient setting. If these medications are effective in the Emergency Department, their delivery methods alone may have advantages over intravenous medications commonly used for acute migraine in EDs, including quicker time to treatment delivery, faster pain relief, and reduced ED length of stay. This investigation is a pilot study to examine rimegepant and zavegepant in an ED, to gain insight on effectiveness in this setting.
This study will administer rimegepant 75 mg ODT single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments to 100 patients in the Emergency Department. It is a single center, open-label, non-controlled 2-group clinical trial (allocated 1:1 to rimegepant or zavegepant via pseudo-random assignment). The study will enroll adults in the ED meeting ICHD-3 criteria for migraine or probable migraine, with or without aura.

Start Date01 May 2025

Sponsor / Collaborator

Icahn School of Medicine at Mount Sinai

[+1]

NCT06898047

/ Not yet recruitingNot Applicable

CORRELATE-UK: COnsistency of Response With RimegEpant Oral Lyophilisate in Acute Treatment of migrainE in the United Kingdom

This is a non-interventional, prospective study that will enroll participants with migraine in the United Kingdom currently in use of rimegepant to acutely treat migraine attacks. Participants will be followed up for up to 12 weeks and will complete a daily questionnaire to self-report the consistency of response to rimegepant in acute treatment of migraine.

Start Date01 Apr 2025

Sponsor / Collaborator

Pfizer Inc.

100 Clinical Results associated with Rimegepant Sulfate

100 Translational Medicine associated with Rimegepant Sulfate

100 Patents (Medical) associated with Rimegepant Sulfate

261

Literatures (Medical) associated with Rimegepant Sulfate

01 Jul 2025·Brazilian Journal of Otorhinolaryngology

New onset migraines after maxillary antrostomy for silent sinus syndrome treated with rimegepant: A rare case report

Article

Author: Gerhardstein, Brian L ; Akinci, Yasemin ; Aggarwal, Aishwarya

04 May 2025·Expert Opinion On Drug Safety

Safety profile of lasmiditan: a retrospective post-marketing pharmacovigilance study based on the real-world data of FAERS database

Article

Author: Zhang, Hongrui ; Zhang, Shuohan ; Jiang, Cheng ; Wan, Xiaochen

BACKGROUND:

Lasmiditan offers a promising option for the treatment of migraines, particularly for individuals with cardiovascular concerns. It is crucial to gather comprehensive safety information of lasmiditan through large-scale post market monitoring.

RESEARCH DESIGN AND METHODS:

This study assessed the safety profile of lasmiditan based on real-world data of FDA Adverse Event Reporting System (FAERS) database. Four disproportionality analysis methods were applied to mining the significant signals. The differences in adverse event signals among different subgroups were investigated concerning race, sex, age, weight, dose, and concomitant drug.

RESULTS:

A total of 820 reports and 1,661 adverse events with lasmiditan as the primary suspected drug were identified. Two new adverse event signals related to nervous system disorders emerged. Females and males were more likely to develop paresthesia and dizziness, respectively. Most common adverse events were more likely to occur in the elderly patients and at high doses.

CONCLUSIONS:

It is essential to be vigilant about the relation of potential nervous system disorders with lasmiditan. The importance of heightened clinical vigilance regarding paresthesia in females and dizziness in males was underscored. Additionally, it is advised to administer a lower initial dose for elderly patients.

01 May 2025·Analytical and Bioanalytical Chemistry

UPLC-Q-TOF–MS/MS and NMR studies for the structural characterization of degradation impurities of rimegepant

Article

Author: Reddy, Jithender G ; Swain, Debasish ; Kollu, Sai Ram Prasad ; Mohanta, Tarzan ; Vuyyala, Bhuvaneshwari

Rimegepant is a type of medication classified as a calcitonin gene-related peptide (CGRP) receptor antagonist, used to treat migraines. The present research focused to identify and characterize its degradation products using the liquid chromatography-high-resolution mass spectrometry (Q-TOF-HRMS) and nuclear magnetic resonance spectroscopy (NMR). The degradation profile of rimegepant was evaluated using forced degradation studies, which included exposure to hydrolysis, oxidation, photolysis, and thermal conditions. The drug degraded under hydrolytic and oxidative conditions whereas it was found to be stable under photolytic and thermal conditions. An Acquity CSH C18 column (2.1 × 100 mm; 1.7 µm) was used to separate the analytes using a mobile phase of 0.1% formic acid in water and 0.1% formic acid in acetonitrile eluting in gradient mode at a flow rate of 0.3 mL/min. The degradation products were separated and identified using the mass fragmentation and accurate mass information obtained from LC-MS. A preparative HPLC was used to isolate the major degradation products for structural identification through 1D and 2D NMR studies. According to ICH Q2 (R1) guidelines, the developed UHPLC-PDA method was validated for its accuracy, precision, linearity, and specificity.

News (Medical) associated with Rimegepant Sulfate

06 Feb 2025

·www.echemi.com

Pfizer Reports 2024 Earnings with $63.6 Billion Revenue and Concerns Over Innovation

On February 4, Pfizer announced its financial results for the fourth quarter and the entire year of 2024, revealing a total revenue of $63.6 billion, a 7% increase year-on-year. The fourth quarter alone saw revenues of $17.8 billion, reflecting a substantial 22% growth compared to the same period last year. However, the net profit for the year was $8.031 billion, with only $410 million generated in the fourth quarter, raising concerns among investors. Pfizer operates through three main business segments: Generic Medicines, Specialty Medicines, and Oncology. The Generic Medicines division reported annual revenues of $30.135 billion, a 2% decline from the previous year. In contrast, the Specialty Medicines segment achieved $16.652 billion in revenue, marking an 11% increase, while the Oncology division saw a 25% rise in revenue, totaling $15.612 billion. In the Generic Medicines segment, sales of the COVID-19 vaccine reached $5.353 billion, down 52% year-on-year. Despite this significant drop, there is no indication that the vaccine has fallen out of favor. Sales of apixaban totaled $7.366 billion, up 9%, although this product is nearing the end of its lifecycle. The pneumonia vaccine family generated $6.411 billion, a slight 1% decline. Notably, sales of Rimegepant, an oral CGRP inhibitor, surged to $1.263 billion, a 36% increase from 2022. The RSV bivalent vaccine Abrysvo brought in $755 million, down approximately $150 million from the previous year. Other pipeline products primarily consist of Pfizer's mature offerings, which generally experienced declines. In the Specialty Medicines sector, the drug Vyndaqel for transthyretin amyloidosis proved to be a significant revenue generator, contributing $5.411 billion in sales, a remarkable 64% increase. However, sales of tofacitinib fell 31% to $1.168 billion due to patent cliffs affecting the immediate-release formulation. The older drug ilaprazole saw sales of $690 million, down 17% year-on-year. Surprisingly, the antibiotic sufentanil still managed to generate $637 million in sales, despite a 4% decline, with a significant portion likely coming from China. The injectable ceftazidime-avibactam (Sivextro) achieved $586 million in sales, a 16% decline, marking it as the first cephalosporin antibiotic to surpass $500 million in sales since 2010. In the Oncology division, palbociclib generated $4.367 billion, down 8% year-on-year. Enzalutamide saw revenues of $2.039 billion, a 23% increase. The new drug padcev (enfortumab vedotin) performed exceptionally well, achieving $1.588 billion in sales during its first full fiscal year. Adcetris (brentuximab vedotin) also showed strong performance, with sales soaring to $1.089 billion. Axitinib generated $978 million, down 6%, while bosutinib remained stable at $645 million. Despite maintaining its position as the world's largest pharmaceutical company, Pfizer faces significant challenges regarding innovation and pipeline development. As of December 2024, the company's market capitalization stood at $150 billion, significantly lower than competitors such as Eli Lilly ($750 billion), Johnson & Johnson ($350 billion), AbbVie ($320 billion), Novo Nordisk ($300 billion), Merck ($250 billion), Roche ($220 billion), Novartis ($210 billion), and AstraZeneca ($200 billion). The pressure to innovate and expand its product pipeline remains a critical concern for Pfizer moving forward.

VaccineFinancial StatementDrug ApprovalClinical ResultBiosimilar

27 Jan 2025

·www.fiercepharma.com

Pfizer shells out nearly $60M to resolve Nurtec kickback claims inherited in Biohaven buyout

A recent settlement resolves allegations that Biohaven induced doctors to write Nurtec prescriptions by paying “improper remuneration," including through speaker payouts and meals at “high end restaurants." Over the years, the U.S. Department of Justice (DOJ) has taken a host of drugmakers to task over alleged kickback payments intended to boost prescriptions. Recently, Pfizer found itself in the agency's crosshairs thanks to one of its M&A plays.Now, Pfizer—which purchased neuroscience specialist Biohaven for $11.6 billion in 2022—is committing more than $59.7 million to resolve the kickback allegations against its subsidiary, the DOJ said Friday.The claims and ensuing settlement revolve around Biohaven’s CGRP receptor antagonist Nurtec ODT, which is cleared to both treat and prevent migraines in adults. The drug, which was the crown jewel in Pfizer’s Biohaven buyout, delivered $928 million in 2023 sales. Pfizer reports its fourth-quarter 2024 financial results next week, and the drug is expected to cross the $1 billion mark for the first time.The settlement resolves allegations—brought forward in a 2021 whistleblower lawsuit—that Biohaven induced doctors to write Nurtec prescriptions by paying “improper remuneration," including through speaker payouts and meals at “high end restaurants," according to a DOJ press release on Monday.Prescribers who attended multiple educational programs on the same topic “received no educational benefit from attending repeat programs,” the DOJ said in its release, while other Biohaven speaker programs were attended by people with no educational need to be there, such as speakers’ spouses, family members or friends.Pfizer’s buyout of Biohaven officially closed Oct. 3, 2022.“The settlement relates to alleged conduct at Biohaven before Pfizer’s acquisition of the company in October 2022 and does not include any admission of liability or wrongdoing,” a Pfizer spokesperson said in an emailed statement.Pfizer is “pleased to put this legacy matter behind us, so that we can continue to focus on the needs of patients," the company's spokesperson said. The allegations against Biohaven first came to light when an ex-staffer filed a whistleblower lawsuit against her former company in the summer of 2021. As part of the deal with the DOJ, the former staffer is in line to receive roughly $8.4 million as her share of the federal settlement, the government explained.While Nurtec was already on a rapid ascent by the time of Biohaven’s acquisition, Pfizer has helped raise the migraine med’s profile even more thanks in part to an ad campaign with award-winning musician and actor Lady Gaga.Biohaven isn't alone in facing allegations over kickbacks in recent years.Last fall, Teva Pharmaceuticals USA and Teva Neuroscience forked over a combined $450 million in a DOJ settlement to resolve claims that they leveraged assistance foundations to fund patients’ copays for the multiple sclerosis blockbuster Copaxone from 2006 through 2017. Prior to that, Biogen in 2022 finalized an agreement to pay $900 million to resolve a lawsuit alleging it paid kickbacks to doctors over a five-year span to boost sales of its own multiple sclerosis drugs. Novartis has also found itself in the DOJ’s sights, paying more than $642 million in 2020 to resolve claims that it offered kickbacks to doctors and illegal copayment support to Medicare to improve pharmaceutical sales.

AcquisitionPatent InfringementDrug Approval

30 Dec 2024

·www.prnewswire.com

Halozyme Announces argenx's VYDURA with ENHANZE® was Granted Regulatory Approval in Japan for Chronic Inflammatory Demyelinating Polyneuropathy

SAN DIEGO, Dec. 30, 2024 /PRNewswire/ -- Halozyme Therapeutics, Inc. (NASDAQ: HALO) (Halozyme) today announced that argenx's VYVDURA (efgartigimod alfa and hyaluronidase-qvfc), which is co-formulated with Halozyme's ENHANZE® drug delivery technology, was granted regulatory approval by Japan's Ministry of Health, Labour and Welfare (MHLW) for adults with chronic inflammatory demyelinating polyneuropathy (CIDP). VYVDURA was approved for CIDP as a once weekly 30-to-90 second subcutaneous injection, which can be self-administered at home, and is the first and only neonatal Fc receptor (FcRn) blocker approved for the treatment of CIDP. "We are pleased that VYVDURA, with our innovative ENHANZE drug delivery technology, is now approved for two indications in Japan, enabling greater flexibility and optionality for generalized myasthenia gravis and CIDP patients," said Dr. Helen Torley, president and chief executive officer of Halozyme. "We look forward to VYVDURA being a new treatment option for an even broader number of patients in Japan." The MHLW approval is based on the ADHERE Study, the largest clinical trial to date studying CIDP. In the ADHERE study, 69% (221/322) of patients treated with VYVDURA, regardless of prior treatment, demonstrated evidence of clinical improvement, including improvements in mobility, function and strength. ADHERE met its primary endpoint (p<0.0001) demonstrating a 61% reduction (HR: 0.39 95% CI: 0.25; 0.61) in the risk of relapse versus placebo. Ninety-nine percent of trial participants elected to participate in the ADHERE+ open-label extension. The safety results were generally consistent with the known safety profile of VYVDURA in previous clinical studies and real-world use. VYVDURA was also approved by the MHLW for manufacturing and marketing in January 2024 and launched in April 2024 for the treatment of generalized myasthenia gravis (gMG). In March 2024, VYVDURA was designated as an Orphan Drug for the treatment of CIDP by the MHLW. About Halozyme Halozyme is a biopharmaceutical company advancing disruptive solutions to improve patient experiences and outcomes for emerging and established therapies. As the innovators of ENHANZE® drug delivery technology with the proprietary enzyme rHuPH20, Halozyme's commercially-validated solution is used to facilitate the subcutaneous delivery of injected drugs and fluids, with the goal of improving the patient experience with rapid subcutaneous delivery and reduced treatment burden. Having touched more than 800,000 patient lives in post-marketing use in nine commercialized products across more than 100 global markets, Halozyme has licensed its ENHANZE® technology to leading pharmaceutical and biotechnology companies including Roche, Takeda, Pfizer, Janssen, AbbVie, Eli Lilly, Bristol-Myers Squibb, argenx, ViiV Healthcare, Chugai Pharmaceutical and Acumen Pharmaceuticals. Halozyme also develops, manufactures and commercializes, for itself or with partners, drug-device combination products using its advanced auto-injector technologies that are designed to provide commercial or functional advantages such as improved convenience, reliability and tolerability, and enhanced patient comfort and adherence. The Company has two commercial proprietary products, Hylenex® and XYOSTED®, partnered commercial products and ongoing product development programs with Teva Pharmaceuticals and Idorsia Pharmaceuticals. Halozyme is headquartered in San Diego, CA and has offices in Ewing, NJ and Minnetonka, MN. Minnetonka is also the site of its operations facility. For more information visit and connect with us on LinkedIn and Twitter. Safe Harbor Statement In addition to historical information, the statements set forth above include forward-looking statements including, without limitation, statements concerning the possible activity, benefits and attributes of ENHANZE®, the possible method of action of ENHANZE®, its potential application to aid in the dispersion and absorption of other injected therapeutic drugs, and statements concerning certain other potential benefits of ENHANZE® including facilitating more rapid delivery of injectable medications through subcutaneous delivery and potentially lowering the treatment burden for patients, including offering flexibility to receive treatment in more convenient locations and broadening the treatment options for the indications referred to in this press release. These forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. The forward-looking statements are typically, but not always, identified through use of the words "expect," "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probable," "potential," "possible," "should," "continue," and other words of similar meaning. Actual results could differ materially from the expectations contained in forward-looking statements as a result of several factors, including unexpected results or delays in launch or commercialization of our partner's product for the indication referred to in this press release, unexpected adverse events or patient experiences or outcomes from being treated with the ENHANZE® co-formulated treatment referred to in this press release, and competitive conditions. These and other factors that may result in differences are discussed in greater detail in Halozyme's most recent Annual and Quarterly Reports filed with the Securities and Exchange Commission. Except as required by law, Halozyme undertakes no duty to update forward-looking statements to reflect events after the date of this release. Contacts: Tram Bui VP, Investor Relations and Corporate Communications 609-359-3016 [email protected] Samantha Gaspar Teneo 212-886-9356 [email protected] SOURCE Halozyme Therapeutics, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Drug ApprovalOrphan DrugClinical Result

100 Deals associated with Rimegepant Sulfate

External Link

KEGG	Wiki	ATC	Drug Bank
-	Rimegepant Sulfate	N02C	DB12457

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Acute migraine	South Korea	Pfizer Pharmaceuticals Korea Ltd.	24 Mar 2025
Migraine Disorders	United States	Pfizer Inc.	27 Feb 2020

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Migraine Without Aura	Phase 3	United States	Pfizer Inc.	11 Mar 2025
Migraine Without Aura	Phase 3	Japan	Pfizer Inc.	11 Mar 2025
Migraine Without Aura	Phase 3	Canada	Pfizer Inc.	11 Mar 2025
Temporomandibular Joint Disorders	Phase 3	United States	Pfizer Inc.	05 May 2022
Chronic rhinosinusitis without nasal polyps	Phase 3	United States	Pfizer Inc.	17 Feb 2022
Nasal Polyps	Phase 3	United States	Pfizer Inc.	17 Feb 2022
Migraine With Aura	Phase 3	United States	Pfizer Inc.	28 Apr 2021
Migraine With Aura	Phase 3	Poland	Pfizer Inc.	28 Apr 2021
Migraine With Aura	Phase 3	Spain	Pfizer Inc.	28 Apr 2021
Abdominal Pain	Phase 2	United States	Pfizer Inc.	06 Jun 2024

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


P1-12.008 (AAN2025)	Not Applicable	Migraine Disorders	-	Rimegepant users	wmvtehbrco(ijxebmdnuw) = iqqqlqizps xphltkwsld (atmyctgnuq ) View more	Positive	07 Apr 2025
				Triptan users	wmvtehbrco(ijxebmdnuw) = jvlwgxoamp xphltkwsld (atmyctgnuq ) View more
NCT05399459 (P8-12.006, AAN2025)	Phase 2/3	Migraine Disorders	706	Rimegepant 25 mg	toiocbaudd(yqbvybyiix) = govvwwjdpb mjxviabsew (hchvezpwnf ) View more	Positive	07 Apr 2025
				Rimegepant 75 mg	toiocbaudd(yqbvybyiix) = acpzyyyfxb mjxviabsew (hchvezpwnf ) View more
P10-12.002 (AAN2025)	Not Applicable	Migraine Disorders calcitonin gene-related peptide (CGRP) antagonists	-	Rimegepant users	lbhryiycil(gxtvopjzlk) = skkfrrhgdt czevwsmltv (dmovoehrel )	Positive	07 Apr 2025
				Oral Triptan users	lbhryiycil(gxtvopjzlk) = znzooyqdhx czevwsmltv (dmovoehrel )
P10-12.008 (AAN2025)	Not Applicable	Migraine Disorders	-	Rimegepant	uhyzvbklzb(wfcwdpiodd) = cvipijgrbe zovynpenya (bcalqsifil )	Positive	07 Apr 2025
				Oral Triptans	uhyzvbklzb(wfcwdpiodd) = cqjpyafkbb zovynpenya (bcalqsifil )
NCT05248997 (CTgov)	Phase 3	Nasal Polyps \| Chronic rhinosinusitis without nasal polyps	261	Rimegepant (Rimegepant 75 mg)	rstapnsnoz(svzrinwixc) = szpykgzmmo uuuhrvdekt (kgvbfsactg, kveqhmuxvn - tiilumexqm) View more	-	26 Mar 2025
				placebo+rimegepant (Placebo)	rstapnsnoz(svzrinwixc) = ivywbgykha uuuhrvdekt (kgvbfsactg, ycwmwycplc - vyyhuugdrb) View more
NCT05371652 (CTgov)	Phase 3	Acute migraine	241	Rimegepant	eozwntpamy = zdvpjijdxm usovqqxgdo (afisptwome, lptkhzcmuo - zxyevwbwys) View more	-	20 Feb 2025
NCT05399459 (P8-12.006, CTgov)	Phase 3	Migraine Disorders	897	Rimegepant 25 MG (Rimegepant 25 mg)	imalqxqdhz = qqkjrvcwhf bgxacxghte (qnvjfphcwz, aiktbpmvgk - udvncswmvl) View more	-	10 Feb 2025
				Rimegepant 75 MG (Rimegepant 75 mg)	imalqxqdhz = zqiubjlemz bgxacxghte (qnvjfphcwz, nzaewkgdty - esposcymrb) View more
NCT03266588 (Pubmed) Manual	Phase 2/3	Migraine Disorders	1,800	Rimegepant 75 mg	ytiwqpbkve(toyocoetxd) = pqnbmotdnk nuxdcsmcel (ojizvsxbsc ) View more	Positive	10 Jul 2024
				Rimegepant (CV risk 1)	ytiwqpbkve(toyocoetxd) = lkqiyzxhxv nuxdcsmcel (ojizvsxbsc ) View more
NCT03235479 (Pubmed) Manual	Phase 3	Migraine Disorders	1,162	Rimegepant 75 mg oral tablet	exqojjlszd(ezekyaugin) = lguyhyrfdj horezglefg (fqvfhfqpjq ) View more	Positive	01 Jul 2024
				Placebo	exqojjlszd(ezekyaugin) = tczxmxwpcj horezglefg (fqvfhfqpjq ) View more
NCT05262517 (CTgov)	Phase 3	Temporomandibular Joint Disorders	126	Rimegepant (BHV3000 (Rimegepant (BHV3000))	ctncivcvus(ctlhhybprb) = upfogbmjdq uaviqhdffy (peazqejuae, qdzgsmpfpp - kjfbwgzvuy) View more	-	16 May 2024
				placebo+rimegepant (Placebo)	ctncivcvus(ctlhhybprb) = lcgrryuvlf uaviqhdffy (peazqejuae, mqjjnunxkd - hesbjyrmkc) View more

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