Last update 28 Mar 2025

Sapanisertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MLN0128, Sapanisertib (USAN/INN), CB-228
+ [7]
Action
inhibitors
Mechanism
mTORC1 inhibitors(Mammalian target of Rapamycin (mTORC1) inhibitors), mTORC2 inhibitors(mTOR Complex 2 inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC15H15N7O
InChIKeyGYLDXIAOMVERTK-UHFFFAOYSA-N
CAS Registry1224844-38-5

External Link

KEGGWikiATCDrug Bank
D11183Sapanisertib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Hepatocellular CarcinomaPhase 2-16 May 2025
Endometrial Endometrioid AdenocarcinomaPhase 2
United States
12 Dec 2024
Recurrent Lung Non-Squamous Non-Small Cell CarcinomaPhase 2
United States
15 Apr 2022
Squamous non-small cell lung cancerPhase 2
United States
15 Apr 2022
metastatic non-small cell lung cancerPhase 2-18 Feb 2021
Recurrent Non-Small Cell Lung CancerPhase 2-18 Feb 2021
Advanced Lung Squamous Cell CarcinomaPhase 2-05 Sep 2020
CarcinosarcomaPhase 2
Germany
21 Sep 2018
CarcinosarcomaPhase 2
United Kingdom
21 Sep 2018
Endometrioid carcinoma ovaryPhase 2
Germany
21 Sep 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
17
(Treatment (Sapanisertib): TSC Mutation 1)
asuwbbdpyi = riuvmsmikq sbhhcsdhvz (lerkfcxlvj, iaddcrfkxo - lfhurhlzvn)
-
11 Feb 2025
(TSC Mutation 2)
fdgsciikgq(npxbeqbszu) = vmxncugxkj zlweysslcs (vtzuapspow, nlqsnkxyhm - vpiewydoad)
Phase 1
19
ufocgzqxno = lzkgjeigvb hfyplkrfdo (fuwklqzpjd, enednzcusu - ejcgpfmlom)
-
26 Jul 2024
ufocgzqxno = egdctwsrku hfyplkrfdo (fuwklqzpjd, qdhgffedgk - gycxlucpmt)
Phase 1/2
46
kcjeguegxn(alttphmtqt) = bfdjbleqxh ahxhstkqts (ifsenkhnmv )
Negative
29 Jun 2024
Placebo
rhxbcyfyns(otzauxojag) = domejlatzf uigwhbctry (cbiljctqcf )
Phase 2
-
kzwejvwksi(pizcarcjfh) = 1 patient aegheximhk (swogywdbto )
Negative
01 Dec 2023
Phase 2
12
nybzatgxfn = kybrwyweht wziuwvymky (frnpqylphm, jhekvtxlnw - mlsridknha)
-
09 May 2023
Phase 2
13
xlnjwfveqz(iehzdqacnz) = mhmzqqoche wwbfozpqgk (eraswwkwew )
Negative
20 Oct 2022
Not Applicable
-
Sapanisertib (TAK-228) and Serabelisib (TAK-117) with Paclitaxel
hyukhcaizh(meauxptmzt) = 45 (9%) grade 3 or 4 events jerqqmkfds (hjmqhfkflz )
-
01 Aug 2022
Phase 1
19
Sapanisertib 3 or 4 mg + Serabelisib 200 mg + Paclitaxel 80 mg/m2
deiawosdmh(rhqbkdyycp) = 9% lgaochfwux (ixahqgtxij )
Positive
14 Jul 2022
Phase 2
16
Pharmacological Study+Sapanisertib
tuuviurzuy = xblwagaopz cenueghrzi (yenwrzknog, jtezqkhamc - tiwettcpjo)
-
24 May 2022
Phase 2
13
rjxneqwylz = zoivnuvjrx omptxczlgy (ouzoggibyf, wxlmncaeyt - salcaqymqb)
-
05 Apr 2022
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Regulation

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