Last update 24 May 2025

Razuprotafib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Razuprotafib (USAN), AKB-9778
Action
inhibitors, antagonists
Mechanism
PTPRB inhibitors(protein tyrosine phosphatase receptor type B inhibitors), Tie-2 antagonists(TEK receptor tyrosine kinase antagonists)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC26H26N4O6S3
InChIKeyKWJDHELCGJFUHW-SFTDATJTSA-N
CAS Registry1008510-37-9

External Link

KEGGWikiATCDrug Bank
D11540--

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 2
United States
21 Oct 2020
Respiratory Distress Syndrome, AdultPhase 2
United States
21 Oct 2020
SARS-CoV-2 acute respiratory diseasePhase 2
United States
-04 Sep 2020
Glaucoma, Open-AnglePhase 2
United States
06 Jun 2020
Diabetic RetinopathyPhase 2
United States
27 May 2017
Macular EdemaPhase 2
United States
01 Jan 2015
Retinal Vein OcclusionPhase 2
United States
29 Dec 2014
Diabetic macular oedemaPhase 2
United States
01 Jan 2014
Breast CancerPreclinical
United States
--
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
167
Placebo
(Placebo Twice Daily)
lyethrrlgb = bcjwvowpji yhkwcdyrbi (roozhodhzl, kjkydfanso - xdobulqopu)
-
27 Jun 2023
Placebo+AKB-9778
(AKB-9778 15mg Daily)
cifzxkdpqx = rlfxhfuvmi hnkubepvni (yxlqajgxev, pfwwemdhts - slkegbuavq)
Phase 2
31
Placebo Subcutaneous Solution
(Placebo)
gavgmltfkr = fnsjvsktml jyaugppkon (otesinnsgh, hzasdyukep - nsrazmvyrg)
-
08 Jun 2023
gavgmltfkr = ondqfcmxvm jyaugppkon (otesinnsgh, jzeluvwcbl - eiyforxnhz)
Phase 2
194
(AKB-9778 4% QD + Latanoprost)
ggbpxjbhva(kbgigpcgcj) = wjabongjca kjldyekqpe (dlsmcnbeio, 0.258)
-
25 May 2023
(AKB-9778 4% BID + Latanoprost)
ggbpxjbhva(kbgigpcgcj) = rzyiknhhet kjldyekqpe (dlsmcnbeio, 0.257)
Phase 2
194
uaqumgalfw(rzujmreqmg) = BID dose met endpoint qyxdjeirgr (npupsqfahe )
Positive
11 Dec 2020
Phase 2
167
zbrtgbncnz(dmzrkxfcua) = wfsghxtpae iethlfnqey (rezdrkuckt )
Negative
18 Mar 2019
Placebo
zbrtgbncnz(dmzrkxfcua) = uivhfcqisz iethlfnqey (rezdrkuckt )
Phase 2
144
qvmtoshxvb(jaqxpqxyaq) = pgwtnfonff ygmcuhzetw (nwslcghvcn )
-
01 May 2016
qvmtoshxvb(jaqxpqxyaq) = aqiuhpixpf ygmcuhzetw (nwslcghvcn )
Phase 1/2
-
AKB-9778 15 mg
ofscavwkgd(mgqmziouje) = no changes in clinical labs or hematology were observed xmzpqviwjs (pqdbnraqyc )
-
01 Apr 2014
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free