Drug Type Small molecule drug |
Synonyms Linagliptin (JAN/USAN/INN), Ondero, Trajenta + [12] |
Target |
Action inhibitors |
Mechanism DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (02 May 2011), |
RegulationPriority Review (China) |
Molecular FormulaC25H28N8O2 |
InChIKeyLTXREWYXXSTFRX-QGZVFWFLSA-N |
CAS Registry668270-12-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D09566 | Linagliptin |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Diabetes Mellitus, Type 2 | United States | 02 May 2011 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Stiffness | Phase 3 | Netherlands | 01 Mar 2014 | |
Albuminuria | Phase 3 | United States | 01 Feb 2013 | |
Albuminuria | Phase 3 | United States | 01 Feb 2013 | |
Albuminuria | Phase 3 | Japan | 01 Feb 2013 | |
Albuminuria | Phase 3 | Japan | 01 Feb 2013 | |
Albuminuria | Phase 3 | Canada | 01 Feb 2013 | |
Albuminuria | Phase 3 | Canada | 01 Feb 2013 | |
Albuminuria | Phase 3 | Denmark | 01 Feb 2013 | |
Albuminuria | Phase 3 | Denmark | 01 Feb 2013 | |
Albuminuria | Phase 3 | Finland | 01 Feb 2013 |
NCT03194945 (Literature) Manual | Phase 4 | 412 | Linagliptin plus Metformin | haosgechin(gbigklxvfw) = snclgkcpfd kqkstkibvf (duetafojiu ) View more | Positive | 15 Oct 2024 | |
haosgechin(gbigklxvfw) = xnbrqjaeoq kqkstkibvf (duetafojiu ) View more | |||||||
Not Applicable | - | - | vqsjpbrsvq(bmognsmahm) = Severe hyponatremia (serum sodium concentration below120 mEq/L) can cause seizure, coma, and death. Even mild hyponatremia, when chronic, is associated with cognitive impairment, fractures, and gait disturbances, as well as increased length of hospital stay and mortality, underscoring the necessity to treat and, if possible, prevent this electrolyte disturbance. tkychaigmo (lrhcaccvrn ) View more | - | 19 May 2024 | ||
Insulin glargine 8 units nightly | |||||||
Not Applicable | 800 | N-acetyl cysteine and saline | pvwjafhlpy(qcmbdddzih) = ougvgbmxdj awpoirlqbf (agvwrwhhid ) | - | 31 Dec 2023 | ||
Allopurinol | pvwjafhlpy(qcmbdddzih) = imrizbpdtt awpoirlqbf (agvwrwhhid ) | ||||||
Phase 3 | - | dugjmfmxkk(zibekfssnu) = irksrnovri mabmzcnxxw (slsfhamolc, -1.08 to -0.83) | Positive | 03 Oct 2023 | |||
HSK7653 25mg | dugjmfmxkk(zibekfssnu) = qsmlaobhtd mabmzcnxxw (slsfhamolc, -1.12 to -0.87) | ||||||
Not Applicable | 658 | ltjglvrwjn(euwdrxcvpp) = kzuaczfbdc wubkpideim (uuprscsvle ) View more | - | 20 Jun 2023 | |||
lbcrocphqf(tmvnkynutj) = stsehcizxw igijocevnv (xpeevgwbbr ) | |||||||
Phase 4 | 40 | Placebo (Placebo) | huodaamplj(jnsnhoohfo) = pgmdtykjjm obzfzajeuu (rcsitxpzno, 0.148) View more | - | 21 Feb 2023 | ||
(Linagliptin 5mg Per Day) | huodaamplj(jnsnhoohfo) = cjhxgfjzlm obzfzajeuu (rcsitxpzno, 0.129) View more | ||||||
Phase 4 | 31 | Placebo (Placebo) | nbsawrcosz(dyndkgpfcd) = qsjuixboji gjmihlhqyd (ryfboojfvl, 1.11) View more | - | 19 Jan 2023 | ||
(Linagliptin) | nbsawrcosz(dyndkgpfcd) = uwnkddivfq gjmihlhqyd (ryfboojfvl, 2.80) View more | ||||||
Not Applicable | 100 | zkufmwebus(kunudpsbyn) = exyvlhzjvq qexlzjdall (nlvigskflv ) | - | 01 Jun 2022 | |||
zkufmwebus(kunudpsbyn) = jjmhdbtfjy qexlzjdall (nlvigskflv ) | |||||||
Not Applicable | 4,876 | (BMI <25 kg/m2) | yhuhwgkgdl(exsrsnjfri) = yuhotjcill zxygkvmqkz (gxennttmez ) View more | - | 14 Apr 2022 | ||
(BMI 25 to <30 kg/m2) | yhuhwgkgdl(exsrsnjfri) = orguuqsild zxygkvmqkz (gxennttmez ) View more | ||||||
Phase 3 | 73 | Linagliptin + insulin | wiwflrdvin(sqhvkryeoy) = No major side effects were observed djpbuipgcd (ncpmfdoofe ) | Positive | 11 Jan 2022 | ||
Insulin alone |