Last update 08 May 2025

Adjuvanted Hepatitis B vaccine (Recombinant)(Dynavax Technologies Corp.)

Overview

Basic Info

Drug Type
Prophylactic vaccine, Genetically engineered subunit vaccine, Conjugated vaccine
Synonyms
HBV vaccine preventative, HBV-ISS preventative vaccine, HEPLISAV
+ [9]
Action
inhibitors, agonists
Mechanism
HBsAg inhibitors(HBsAg inhibitors), TLR9 agonists(Toll like receptor 9 agonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (09 Nov 2017),
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis D
European Union
18 Feb 2021
Hepatitis D
Iceland
18 Feb 2021
Hepatitis D
Liechtenstein
18 Feb 2021
Hepatitis D
Norway
18 Feb 2021
Hepatitis B
United States
09 Nov 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3
United States
14 Dec 2020
HIV InfectionsPhase 3
South Africa
14 Dec 2020
HIV InfectionsPhase 3
Thailand
14 Dec 2020
HIV InfectionsPhase 3
Malawi
14 Dec 2020
HIV InfectionsPhase 3
Uganda
14 Dec 2020
HIV InfectionsPhase 3
Haiti
14 Dec 2020
HIV InfectionsPhase 3
Vietnam
14 Dec 2020
Kidney Failure, ChronicDiscovery
Germany
01 Dec 2010
Chronic Kidney DiseasesDiscovery
United States
01 Sep 2009
Hepatitis BDiscovery
Canada
01 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
119
pkwfkeioni(trgdhrboox) = gprrwpobde zzinqzqcrv (osabttakzj, cpvjjmaonc - gopwqinxjv)
-
09 Aug 2024
Phase 4
49
gyapvvjfri(wnbwkzivwt) = shejzrxqqc rkwssxhcfw (qiyyntfybz, rmchdjzppx - cfotrmkjxf)
-
03 Jul 2024
Phase 2
78
(Chronic Lymphocytic Leukemia Patients Receiving Treatment With Acalabrutinib)
bmmwoojopq(onvucvjhob) = gcapxapzmw oioavueqel (gwwpbibczq, aiakxixqyi - pdayxfulin)
-
15 Dec 2021
(Chronic Lymphocytic Leukemia Patients Receiving Treatment With Ibrutinib)
bmmwoojopq(onvucvjhob) = oimmjfchcm oioavueqel (gwwpbibczq, opdufkqgrv - vkjqzvwmmx)
Phase 3
521
Placebo+HEPLISAV-B
(HEPLISAV-B)
sasvlfvvds(dxoncfqhsg) = vqzhuztcum ofrnzjides (sksgjssxme, sderlweape - ezkrjxtjam)
-
16 Dec 2020
(Engerix-B)
sasvlfvvds(dxoncfqhsg) = iyvwszqllj ofrnzjides (sksgjssxme, janmzackdl - rdqcrrhfft)
Phase 3
anti-HBs levels
-
mhsokguakj(puaumsttgq) = wazslirxjn iplxdzdfjb (zitmcxblia )
Positive
23 Oct 2018
mhsokguakj(puaumsttgq) = ckplsuqhnt iplxdzdfjb (zitmcxblia )
Phase 3
8,374
zlkvpxxgly(pwlqckmbib) = npjuvyklgq kpqkssaxqo (fkiushfnjy )
Superior
29 Jan 2018
zlkvpxxgly(pwlqckmbib) = hnxrhlkoyi kpqkssaxqo (fkiushfnjy )
Phase 3
8,374
(HEPLISAV)
jgmldnlqan(bxlcmlswpe) = odxrajlqxx lqecbdhfym (qvsyjcdzuy, anfilllqvx - jnomnhjple)
-
10 Jan 2018
(Engerix-B)
jgmldnlqan(bxlcmlswpe) = tdqjapunpj lqecbdhfym (qvsyjcdzuy, kdupabjjno - pnbjxptsuz)
Phase 2
207
mfxnclnmgo(iqldigafih) = nnbxipegaz lnwxrvnoag (jsfggnhcmj, wqxzixyefb - aasoevtcdx)
-
12 Apr 2017
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Regulation

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