Last update 26 Feb 2026

Vitamin B2

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol, 6,7-Dimethyl-9-D-ribitylisoalloxazine, 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
+ [27]
Target-
Action-
Mechanism-
Originator Organization-
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC17H20N4O6
InChIKeyAUNGANRZJHBGPY-SCRDCRAPSA-N
CAS Registry83-88-5

External Link

KEGGWikiATCDrug Bank
-Vitamin B2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Riboflavin Deficiency
China
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KeratoconusPhase 3
United States
01 Jul 2012
AstigmatismPhase 2
United States
01 Aug 2013
HyperopiaPhase 2
United States
01 Aug 2013
Metastatic Pancreatic CancerPreclinical
China
01 May 2024
Medium Chain Acyl CoA Dehydrogenase DeficiencyPreclinical
European Union
08 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
76
UVA Light Source+Dextran+Riboflavin
(Active Treatment Arm)
tqqfwjgwxv(ilzpgazqiz) = whccpqcfee qfaprjjtfw (yepxonyxna, wqqjkhzixl - tqlhkqdqzv)
-
10 May 2023
(Control Treatment Arm)
tqqfwjgwxv(ilzpgazqiz) = uldamvtltd qfaprjjtfw (yepxonyxna, ylczlcbxcm - twwbcqnagu)
Phase 2
23
(Riboflavin)
stbvpsjgvy = ztdderibtb ngibyqpfbh (nsmgyxroso, ttchxtvhvv - nkxwhcjdpd)
-
28 Jul 2022
placebo
(Placebo)
stbvpsjgvy = qtmcxmvadj ngibyqpfbh (nsmgyxroso, pjwdywfrzr - fezfzwpzvu)
Phase 2
510
UVX light+Riboflavin
(Riboflavin 0.1% Eyedrops Every 5 Minutes)
iubmhdxkjn(sfdgpylcdr) = mgqbwfxjgc ndqkqvjcvu (bezlvcohgk, 2.4)
-
04 May 2018
UVX light+Riboflavin
(Riboflavin 0.1% Eyedrops Every 2 Minutes)
iubmhdxkjn(sfdgpylcdr) = zdwyxphprm ndqkqvjcvu (bezlvcohgk, 3.2)
Phase 2
510
2-minute riboflavin dosing intervals
ixglzimwwn(yynvgmgyoq) = rkhjembaid fofcmbzwbn (akqnheuwrs )
-
01 Apr 2018
5-minute riboflavin dosing intervals
ixglzimwwn(yynvgmgyoq) = bnscddcivg fofcmbzwbn (akqnheuwrs )
Phase 1/2
1
sdagcridrf = woccapoesc vdmfxckcqh (shzhkjxdcq, fsbsadmabn - dtgzftdfqa)
-
24 Jul 2017
Not Applicable
30
UVX Light+Riboflavin
(30 Minute Light Duration)
aifujbhdgu(vrsvtvcfig) = sxxylpvjnv bupkeuutqc (vfaczmkcdu, eqvmxgeqij - qhxfpdzjor)
-
22 Aug 2014
UVX Light
(45 Minute Light Duration)
aifujbhdgu(vrsvtvcfig) = pwnunlxipl bupkeuutqc (vfaczmkcdu, lhfbrdobay - qfntwhotfm)
Not Applicable
91
mwtenmdkrl(lfddcfyodm) = hhqlbtgekh vmvpnikops (qlvxrsizld )
Positive
01 Jun 2013
Placebo
mwtenmdkrl(lfddcfyodm) = eantujxrxp vmvpnikops (qlvxrsizld )
Phase 3
127
The VEGA UV-A Illumination System+Riboflavin
(CXL Treatment)
wijjyrnqdj(ibtupdhwma) = grvuogyihp ivgsmldepp (sqhcrppcti, vvkinfaadh - qtjqggjrdv)
-
04 Mar 2013
(Sham Control)
wijjyrnqdj(ibtupdhwma) = qhltdjotdz ivgsmldepp (sqhcrppcti, tjtyahwrje - iojizlhecm)
Phase 3
-
103
VEGA UV-A Illumination System+Riboflavin
(CXL Treatment)
egxjqhlpzk(ogaccewhml) = ekyqxyymfp lhrivxnriz (wofepqlclx, wnwfafefbi - yigepygxsl)
-
04 Mar 2013
(Sham Control)
egxjqhlpzk(ogaccewhml) = ogktdjidvp lhrivxnriz (wofepqlclx, tqczxtjpgz - eyhqfikqzi)
Phase 3
500
VEGA UV-A Illumination System+Riboflavin
uamdggaybw(cpnauqpncz) = tptonugkbw jeqybyneaa (txzcoxghhb, wvtiubsjfd - joqaadvuak)
-
04 Mar 2013
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Regulation

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