Vitamin B2

From America's #1 Folate Brand: Folinic Acid Formula Addresses the Needs of the 15-25% of Adults Who Benefit from a Different Approach AUSTIN, Texas, May 18, 2026 /PRNewswire/ -- Triquetra Health, a clinical-grade supplement company developing evidence-based nutritional formulas, today announced the launch of FolinicActive™ Adult 1 mg, a multi-pathway active folate supplement combining folinic acid (calcium folinate) with a proprietary Tri-Cofactor System for adults seeking a gentler, more flexible approach to folate support. The folinic acid supplement is now available on Amazon, offering adults an alternative to L-methylfolate through a formulation designed to let the body direct folate where it's needed most. Continue Reading The image shows a Triquetra FolinicActive™ Folinic Acid dietary supplement bottle and box. The product contains 1 mg folinic acid with vitamins B9, B12, B6, and B2, designed to support brain, mood, heart, and nerve health. The package includes 60 capsules and features a modern blue-and-white design. An estimated 15-25% of adults who try L-methylfolate report restlessness, sleep disruption, or an uncomfortable "wired" feeling—an experience that often leads them to discontinue use. L-methylfolate goes directly to methylation, one pathway and one direction, which works well for most users. For a meaningful subset of adults, however, a more flexible mechanism may better match their individual needs. These individuals have historically had few evidence-based alternatives in the supplement category. FolinicActive™ addresses this gap through multi-pathway active folate—folinic acid (5-formyl-THF) sitting upstream in folate metabolism, where the body may direct it toward DNA synthesis or methylation depending on current requirements. Unlike L-methylfolate, which channels all folate into a single downstream pathway, folinic acid functions as a metabolic hub supplying both pathways simultaneously. This multi-pathway flexibility is the defining mechanism of the FolinicActive™ formula. The product is available at amazon.com/dp/B0G4S6T2F9. What distinguishes FolinicActive™ further is The Complete Tri-Cofactor System—a formulation approach that goes beyond isolated folinic acid to include the full suite of helper nutrients folate metabolism requires. The formula provides a B-12 tri-blend (800 mcg methylcobalamin, 100 mcg adenosylcobalamin, 100 mcg hydroxocobalamin) for complete cellular coverage, active B-6 as pyridoxal-5′-phosphate (P-5-P, 5 mg) to support an additional homocysteine pathway, and active B-2 as riboflavin-5′-phosphate (R-5-P, 2 mg), the cofactor MTHFR enzyme requires to function. Published research by McNulty et al. (2023, Proceedings of the Nutrition Society) demonstrated 28-40% homocysteine reduction in MTHFR 677TT carriers with riboflavin supplementation—yet fewer than 3% of methylation supplements include any form of riboflavin. FolinicActive™ includes the active R-5-P form. "Standard L-methylfolate formulas work very well for the majority of adults seeking folate support," said Sean Gill, Founder and CEO of Triquetra Health. "But for the 15-25% who find that direct approach too intense—who've tried L-methylfolate and experienced restlessness, sleep issues, or that uncomfortable feeling—there's been essentially nothing designed specifically for them. FolinicActive™ delivers multi-pathway active folate with The Complete Tri-Cofactor System: your body directs folate where it's needed, supported by every cofactor the process requires. This is what we mean by complete folate solutions for every need. We built this for the people who've been underserved by the existing category." FolinicActive™ is available in two adult formats: a USDA Organic liquid (30 mL, 60 servings at 0.50 mL daily) and a vegan capsule (60 count, 1 capsule daily). Both deliver identical active ingredients at identical doses—1 mg folinic acid, 1,000 mcg B-12 tri-blend, 5 mg P-5-P, and 2 mg R-5-P—enabling flexible format selection without any change in formulation. The liquid and capsule products are manufactured in FDA-registered, cGMP-certified facilities with third-party testing for purity, potency, and heavy metals. For complete product information, visit triquetrahealth.com. FolinicActive™ Adult 1 mg is available now on Amazon at . Ideal for those who need an alternative to L-methylfolate, FolinicActive™ offers multi-pathway flexibility, complete cofactor support, and formats for every lifestyle. From America's #1 folate brand—complete folate solutions for every need. Learn more at triquetrahealth.com. About Triquetra Health Triquetra Health develops clinically-validated nutritional supplements for consumers seeking evidence-based approaches to wellness. The company specializes in formulation science that addresses the gaps conventional supplements leave behind—from bioavailability limitations to incomplete cofactor support. All Triquetra products are manufactured in FDA-registered, cGMP-certified facilities with rigorous third-party testing for purity, potency, and safety. Triquetra Health is America's #1 folate brand, offering complete folate solutions for every need. For more information, visit triquetrahealth.com. Media Contact: LeAnna Doughty Director of Communications [email protected] + (844) 272-6337 SOURCE Triquetra Health LLC 21% more press release views with Request a Demo

Scientists have uncovered a surprising dark side to vitamin B2: it may help cancer cells stay alive. The vitamin supports a cellular shield that protects tumors from ferroptosis, a form of programmed cell death linked to cancer suppression. In lab tests, researchers used a vitamin B2-like compound called roseoflavin to break down that protection and trigger cancer cell death.Vitamin B2 is essential for human health, but new research suggests it may also help cancer cells stay alive. Also known as riboflavin, vitamin B2 cannot be produced by the body and must come from food sources such as dairy products, eggs, meat, and green vegetables. Once absorbed, the vitamin is converted into molecules that help protect cells from oxidative damage and support other important biological functions. Scientists at the Rudolf Virchow Centre (RVZ) at Julius-Maximilians-Universität Würzburg (JMU) have now discovered that this protective effect may come with a serious drawback. Their findings show that vitamin B2 metabolism can also shield cancer cells from destruction. "Vitamin B2 plays a crucial role in protecting cancer cells from ferroptosis, a special form of programmed cell death," says PhD student Vera Skafar. She is part of the research team led by José Pedro Friedmann Angeli, Professor of Translational Cell Biology. The study was published in Nature Cell Biology. How Vitamin B2 Helps Cancer Cells Survive Programmed cell death is one of the body's natural defense systems. It allows damaged or dangerous cells to die in a controlled way without triggering inflammation in nearby tissue. Ferroptosis is one type of this process and has been linked to cancer, neurodegenerative diseases, and other serious conditions. Ferroptosis occurs when iron-driven damage to cell membranes overwhelms a cell's antioxidant defenses. Cancer cells often avoid this fate by strengthening systems that protect them from oxidative stress. The new study found that vitamin B2 metabolism plays an important role in these protective defenses. According to the researchers, this means that blocking riboflavin-related pathways could make tumors more vulnerable to ferroptosis and easier to destroy. Researchers Test a Possible Cancer Therapy Strategy A protein called FSP1 was central to the team's investigation. The protein helps healthy cells avoid unwanted cell death, and vitamin B2 supports its activity. Using genome editing and cancer cell models, the researchers found that cancer cells became much more sensitive to ferroptosis when vitamin B2 was limited. The team believes this process could eventually be used as a cancer treatment by shutting down vitamin B2 metabolism in tumors and triggering cancer cell death. However, there is currently no inhibitor specifically designed for that purpose. To explore the idea further, the researchers tested roseoflavin, a naturally occurring compound produced by bacteria that has a structure similar to vitamin B2. Roseoflavin Successfully Triggered Ferroptosis In laboratory experiments using cancer cell models, the researchers found that roseoflavin was able to trigger ferroptosis even at low concentrations. "It turned out that roseoflavin triggers ferroptosis in low concentrations," says the group leader, "our experiments show the feasibility of this concept." The findings suggest that targeting vitamin B2 metabolism could become a promising new approach for future cancer therapies based on ferroptosis. Next, the RVZ research team plans to develop more effective inhibitors of vitamin B2 metabolism and test them in preclinical cancer models. Potential Implications Beyond Cancer Friedmann Angeli says the importance of ferroptosis extends beyond oncology. "Ferroptosis is not only relevant to cancer. Increasing evidence suggests that it also contributes to pathological processes in neurodegenerative diseases and in tissue damage following organ transplantation or ischemia-reperfusion injury." Because of this, understanding how vitamin B2 metabolism influences ferroptosis could eventually help scientists better understand a wide range of diseases involving excessive or insufficient cell death. The research was supported by the German Research Foundation (DFG) through the priority program "Ferroptosis: from Molecular Basics to Clinical applications" (SPP2306). The work was also conducted as part of the DeciFerr (Deciphering and exploiting ferroptosis regulatory mechanism in cancer) project led by Professor Friedmann Angeli. Since May 2024, the project has received funding from the European Research Council (ERC) through an ERC Consolidator Grant worth nearly two million euros.