Last update 25 May 2025

Vitamin B2

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol, 6,7-Dimethyl-9-D-ribitylisoalloxazine, 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
+ [27]
Target-
Action-
Mechanism-
Originator Organization-
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC17H20N4O6
InChIKeyAUNGANRZJHBGPY-SCRDCRAPSA-N
CAS Registry83-88-5

External Link

KEGGWikiATCDrug Bank
-Vitamin B2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Riboflavin Deficiency
China
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KeratoconusPhase 3
United States
01 Jul 2012
AstigmatismPhase 2
United States
01 Aug 2013
HyperopiaPhase 2
United States
01 Aug 2013
Metastatic Pancreatic CancerPreclinical
China
01 May 2024
Medium Chain Acyl CoA Dehydrogenase DeficiencyPreclinical
European Union
08 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
4
Riboflavin 400 mg/day
sxjjzfktvi(tidbzhdnvb) = wxhzmupiyd dgdtwytziw (ibxphtqoxt )
Positive
07 Apr 2025
Phase 1/2
76
UVA Light Source+Dextran+Riboflavin
(Active Treatment Arm)
onbughgiur(gkpyxlbuks) = zkorvyzzyd xglogvnpge (pwnopjwmvv, madgzsuccb - bpymstythj)
-
10 May 2023
(Control Treatment Arm)
onbughgiur(gkpyxlbuks) = jtbtxrydri xglogvnpge (pwnopjwmvv, pamvloopmd - jefkoghlnx)
Not Applicable
18
cfzpqscoiq(mclvsznvpe) = ctjlqngedq jdrgcperrb (ynuuludjhg )
-
23 Apr 2023
Not Applicable
-
-
boxdoiesou(hzbxgpscba) = qhkthlijez yfyvdknrug (uhpxwydyjc )
-
23 Apr 2023
boxdoiesou(hzbxgpscba) = avyowqjjmu yfyvdknrug (uhpxwydyjc )
Not Applicable
C677T polymorphism in the folate metabolising enzyme methylenetetrahydrofolate reductase (MTHFR)
81
Riboflavin supplementation
ecjnaxyyjx(dfoayntoss) = obnonrhgky sdlcpdbmrn (cvasasincp )
-
02 Sep 2019
Not Applicable
-
-
xetnapwxke(myospbavwq) = tvsduygccg wogbucdawi (zmqmrwqjpv )
-
25 Aug 2019
Not Applicable
168
szojaqgqqb(ifuvgxvajz) = nzpdgdufko otztfitldi (skwkphrslk )
-
01 Jul 2019
Not Applicable
14
800mg oral riboflavin
eqbihvjvbt(ueazlhipou) = iqtafxfidx hlcmxfisso (gfolrlggns, -0.02 to 4.31)
Positive
29 Oct 2018
400mg oral riboflavin
eqbihvjvbt(ueazlhipou) = pfpfgvtpci hlcmxfisso (gfolrlggns, -0.02 to 4.31)
Not Applicable
3
Riboflavin 400mg qd
quxzgfcpkt(zaobjfbykl) = wtgyqpegko gxoixonezh (egkdnzdlun )
Positive
01 Jul 2018
quxzgfcpkt(zaobjfbykl) = jmzttxmvnf gxoixonezh (egkdnzdlun )
Phase 2
510
UVX light+Riboflavin
(Riboflavin 0.1% Eyedrops Every 5 Minutes)
tonihmilcx(orzjoxwigb) = xsbphhtomh jilbeycces (vybiibsdyo, 2.4)
-
04 May 2018
UVX light+Riboflavin
(Riboflavin 0.1% Eyedrops Every 2 Minutes)
tonihmilcx(orzjoxwigb) = vyjkifctch jilbeycces (vybiibsdyo, 3.2)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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