Netarsudil Mesylate

February 6, 2024 – release at 7:30 am CET Sophia Antipolis, France Nicox SA (Euronext Growth Paris: FR0013018124, ALCOX), an international ophthalmology company, today announced presentations on NCX 470 and NCX 1728 at the upcoming Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2024, a key ophthalmology conference which will be held from May 5 to May 9, 2024 in Seattle, WA, United States. Abstract/Presentation Title: Tolerability and intraocular pressure (IOP)-lowering efficacy following 5-day repeated dosing with NCX 470 0.1% ophthalmic solution, Lumigan® and Rhopressa®: a comparative head-to-head study in rabbits and dogs Type: Poster Session Session Title: Tools and advancements in glaucoma diagnosis, monitoring, medications, and lasers Date: May 6, 2024 from 8:30 am to 10:15 am (U.S. local time) Presenter: Francesco Impagnatiello, PhD, Nicox Research Institute NCX 470, a novel NO-donating bimatoprost eye drop, is currently in Phase 3 clinical development for the lowering of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. Results of Mont Blanc, the first of the two Phase 3 clinical trials, have been announced in October 2022. The second Phase 3 clinical trial, Denali, is currently ongoing, and the results are expected in 2025, based on current recruitment rates. Abstract/Presentation Title: NCX 1728, a novel nitric oxide (NO)-donating avanafil: Formulation development and in vivo testing in a rabbit model of ischemia/reperfusion injury of the optic nerve head and retina Type: Poster Session Session Title: Neuroprotection, blood flow, ischemia-reperfusion and aqueous humor dynamics Date: May 5, 2024 from 3:15 pm to 5:00 pm (U.S. local time) Presenter: Corinna Galli, PhD, Nicox Research Institute NCX 1728 is an NO-donating phosphodiesterase-5 (PDE5) inhibitor, the lead compound in a new class of NO-donating molecules based entirely on NO-mediated activity. NCX 1728 is currently under preclinical evaluation for development in retinal conditions. Nicox Corporate Status Update The Company estimates it is financed until June 2024, based exclusively on the development of NCX 470. The Company is pursuing licensing and other business development discussions, exploring multiple strategic options and is also discussing with its creditors to restructure its debt. About Nicox Nicox SA is an international ophthalmology company developing innovative solutions to help maintain vision and improve ocular health. Nicox’s lead program in clinical development is NCX 470, a novel nitric oxide-donating bimatoprost eye drop, for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Nicox generates revenue from VYZULTA® in glaucoma, licensed exclusively worldwide to Bausch + Lomb, and ZERVIATE® in allergic conjunctivitis, licensed in multiple geographies, including to Harrow, Inc. in the U.S., and Ocumension Therapeutics in the Chinese and in the majority of Southeast Asian markets. Nicox, headquartered in Sophia Antipolis, France, is listed on Euronext Growth Paris (Ticker symbol: ALCOX) and is part of the CAC Healthcare index. For more information . Analyst coverage Bryan, Garnier & Co Eric Yoo Paris, France H.C. Wainwright & Co Yi Chen New York, U.S. The views expressed by analysts in their coverage of Nicox are those of the author and do not reflect the views of Nicox. Additionally, the information contained in their reports may not be correct or current. Nicox disavows any obligation to correct or to update the information contained in analyst reports. Contacts Nicox Gavin Spencer Executive Vice President, Chief Business Officer & Head of Corporate Development T +33 (0)4 97 24 53 00 communications@nicox.com Forward-Looking Statements The information contained in this document may be modified without prior notice. This information includes forward-looking statements. Such forward-looking statements are not guarantees of future performance. These statements are based on current expectations or beliefs of the management of Nicox S.A. and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Nicox S.A. and its affiliates, directors, officers, employees, advisers or agents, do not undertake, nor do they have any obligation, to provide updates or to revise any forward-looking statements. Risks factors which are likely to have a material effect on Nicox’s business are presented in section 2.7 of the “Rapport Annuel 2022” and in section 4 of the “Rapport semestriel financier et d’activité 2023” which are available on Nicox’s website ( ). Nicox S.A. Drakkar 2 Bât D, 2405 route des Dolines 06560 Valbonne, France T +33 (0)4 97 24 53 00 F +33 (0)4 97 24 53 99 Attachment EN_ARVO 2024_ABSTRACTS_ 20240206_F

AR-15512 is a transient receptor potential melastatin 8 (TRPM8) agonist, which was added to Alcon’s portfolio following the acquisition of Aerie Pharmaceuticals in November 2022. Image Credit: Rabizo Anatolii / Shutterstock. Switzerland-based Alcon’s dry eye disease drug AR-15512 achieved primary endpoints in two Phase III trials, COMET-2 and COMET-3. In light of the positive data, the company plans to file for a new drug application (NDA) for AR-15512 with the US Food and Drug Administration (FDA) in mid-2024, as per a 9 January press release. The vehicle-controlled Phase III COMET-2 (NCT05285644) and COMET-3 (NCT05360966) trials enrolled more than 930 patients, aged 30 years and older, with dry eye disease. The studies met their primary endpoints with a significant proportion of the patients in the treatment arm demonstrating at least a 10mm increase in unanaesthetised Schirmer’s score at day 14. An increase of 10mm or more in Schirmer’s score signifies normal tear production. The participants in the AR-15512 treatment arm also showed rapid onset and sustained tear production compared to the vehicle. The changes in tear production were observed on the first day and persisted for the whole 90-day study duration. Alcon noted that AR-15512 was well tolerated, with no serious ocular adverse events being reported during the trials. AR-15512 is a transient receptor potential melastatin 8 (TRPM8) agonist. TRPM8 is a cold-sensing receptor located in the cornea and eyelid and can potentially relieve symptoms of dry eye disease. It was added to Alcon’s portfolio following the $930m acquisition of Aerie Pharmaceuticals in November 2022. The acquisition also included marketed ophthalmic drugs such as Rocklatan, a netarsudil and latanoprost ophthalmic solution; and Rhopressa, a netarsudil ophthalmic solution. Both of these drugs are indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. The dry eye disease market is forecasted to generate $11.1bn in sales across the seven major markets in 2028, as per GlobalData analysis . GlobalData is the parent company of Pharmaceutical Technology . Another late-stage drug being developed as a treatment for dry eye disease is Aldeyra Therapeutics’ reproxalap. The drug had a mixed bag of results as it demonstrated significant improvement in the Schirmer test in both Phase III TRANQUILITY (NCT04674358)and TRANQUILITY-2 (NCT05062330) trials but failed to meet its primary endpoint of reduction in conjunctival redness in the Phase III TRANQUILITY trial. In November 2023, the FDA rejected the reproxalap’s NDA and requested additional data to show the drug’s efficacy.