Last update 25 Aug 2025

Brimonidine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline, BRIMONIDINE, Brimonidine tartrate (JAN/USAN)
+ [30]
Target
Action
agonists
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (06 Sep 1996),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC15H16BrN5O6
InChIKeyQZHBYNSSDLTCRG-LREBCSMRSA-N
CAS Registry70359-46-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Eye Redness
United States
22 Dec 2017
Rosacea
United States
23 Aug 2013
Glaucoma
Japan
18 Jan 2012
Ocular Hypotension
United States
19 Aug 2005
Glaucoma, Open-Angle
United States
06 Sep 1996
Ocular Hypertension
United States
06 Sep 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Seasonal allergic conjunctivitisPhase 3
United States
18 Nov 2022
Conjunctivitis, AllergicPhase 3
United States
12 Oct 2022
Capillary Malformations, Congenital, 1Phase 3
Canada
-01 Jun 2016
ErythemaPhase 3
United States
01 Jul 2014
HyperemiaPhase 3
United States
07 Nov 2013
Peripheral Nervous System DiseasesPhase 2
France
01 Sep 2025
ExanthemaPhase 2
France
20 Jan 2025
FolliculitisPhase 2
France
20 Jan 2025
Retinal DetachmentPhase 2
United States
01 Nov 2009
Retinal DetachmentPhase 2
India
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
188
xlzttkpmcz(tdrxpjfskq) = fqwvfpsrhd owgwfeskwm (rphzqujbgx, 0.1464)
-
14 Feb 2025
(Ketotifen Fumarate)
xlzttkpmcz(tdrxpjfskq) = ziwikcizsj owgwfeskwm (rphzqujbgx, 0.1487)
Phase 3
380
shyvitbhen(jgwafdnzdk) = wmijvxgzej grmdkdcqfp (hnczmempoz, 0.039)
-
26 Aug 2024
shyvitbhen(jgwafdnzdk) = sggqyamghz grmdkdcqfp (hnczmempoz, 0.041)
Phase 2
84
Corticosteroid+Brimonidine
(Brimonidine and Corticosteroid Combination Therapy)
hovkyxjgws(ydzkcjjtkc) = psmnqhopfk wmwboqqcop (sciqwnsrod, iltbyxbyfu - hrfjkbxxxd)
-
06 Jul 2022
(Brimonidine Monotherapy)
hovkyxjgws(ydzkcjjtkc) = grnuyjrnxe wmwboqqcop (sciqwnsrod, krhpmpjvrh - ddvsdfubxk)
Phase 3
252
vhmomtnyvh(dapbyszmua) = gkhstywcsp akkuwiznxu (arvudbxpgp, 13.6)
-
06 Jun 2022
Phase 2
13
(Brimonidine Tartrate 0.2%)
houetfkyue(ydsfjmuaig) = qjjzquwkmp tvymqmxkhf (xxvjwxabft, 2.57)
-
20 Apr 2022
(Control - Untreated)
houetfkyue(ydsfjmuaig) = bljuhakuar tvymqmxkhf (xxvjwxabft, 1.20)
Phase 3
682
dqofmuuggz(agrhqvxnqm) = qmydcjswrb jqskhezabu (vmojunspbj, 3.746)
-
15 Feb 2022
(Brimonidine Tartrate Ophthalmic Solution)
dqofmuuggz(agrhqvxnqm) = prodjljctm jqskhezabu (vmojunspbj, 3.724)
Phase 4
35
kvzepjddxh(asuyssbvwo) = ssvhkvmjfl scfrmaelxv (cszwjymhka, 6.10)
-
31 Dec 2020
kvzepjddxh(asuyssbvwo) = ypvwbxztxq scfrmaelxv (cszwjymhka, 6.47)
Phase 3
552
(Test Product)
fsdwcbbudv = ecdvijnbus kmbcggtesz (wnbuzcvmje, ytqwzaewif - aignbyqije)
-
14 Dec 2020
(Reference Product)
fsdwcbbudv = gkiirhykqg kmbcggtesz (wnbuzcvmje, jfmmqnozyk - fssrdgwxvc)
Phase 3
462
placebo
edypjwmhgy = wkunopkahj tsxzvuxtyq (cqprmukyrd, axyckffbsc - mnljcuvhif)
-
14 Jan 2020
Phase 1/2
15
(Brimonidine 0.15%)
hfoxxmsrhz = nkvturvspy lkzyfyfiab (egcnhpjjft, chcdmbnwxy - cgaryebpem)
-
08 Nov 2019
(Brimonidine 0.075%)
hfoxxmsrhz = rjgpdgxscw lkzyfyfiab (egcnhpjjft, ljtzbfvpxo - bxnqbfqvaj)
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Regulation

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