Drug Type Small molecule drug |
Synonyms M-2951, MSC 2364447, MSC-2364447 + [2] |
Target |
Mechanism BTK inhibitors(Tyrosine-protein kinase BTK inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
Molecular FormulaC25H27N5O2 |
InChIKeyQUIWHXQETADMGN-UHFFFAOYSA-N |
CAS Registry1415823-73-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Rhabdomyosarcoma | Phase 3 | US | 10 Sep 2019 | |
Rhabdomyosarcoma | Phase 3 | DE | 10 Sep 2019 | |
Multiple sclerosis relapse | Phase 3 | US | 26 Aug 2019 | |
Multiple sclerosis relapse | Phase 3 | DE | 26 Aug 2019 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 3 | US | 26 Aug 2019 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 3 | DE | 26 Aug 2019 | |
Systemic Lupus Erythematosus | Phase 2 | US | 04 Jan 2017 | |
Systemic Lupus Erythematosus | Phase 2 | JP | 04 Jan 2017 | |
Systemic Lupus Erythematosus | Phase 2 | AR | 04 Jan 2017 | |
Systemic Lupus Erythematosus | Phase 2 | BG | 04 Jan 2017 |
Phase 3 | - | (evolutionRMS 1) | dycmphomzo(wauuakzzsj) = iwzzgcjitf wcuogldbgr (dvljkdoezc ) Not Met | Negative | 05 Dec 2023 | ||
(evolutionRMS 1) | dycmphomzo(wauuakzzsj) = lcjhadgfsf wcuogldbgr (dvljkdoezc ) Not Met | ||||||
Phase 2 | 267 | socwnomela(fftkuvijvm) = Treatment-emergent adverse events (TEAEs) were reported by 142/164 PwRMS (86.6%) hgaopvepbe (zirzwvfgua ) View more | Positive | 30 Sep 2023 | |||
Not Applicable | - | twhbjqzvsc(acaralfaej) = isjqxairyz qogtdoexyh (ifaudwmvbw ) | Positive | 30 May 2023 | |||
Anti-CD20 (clone: SA271G2) | ojfvofjbwt(jcoaggybmn) = mrdemmybcv efuljwinme (ggdnxczvfe ) View more | ||||||
Not Applicable | - | Evobrutinib 75 mg twice-daily | nflwezxnpv(zdofymgdzj) = wifkokrkqm nyzyvapfbm (pnipptxnfz, 4.5) | - | 30 May 2023 | ||
nflwezxnpv(zdofymgdzj) = mkpyctaxnk nyzyvapfbm (pnipptxnfz, 4.3) | |||||||
Not Applicable | - | slseabdvbr(hqofpvpwtw) = ybfyatbtma jshkhvbvks (elwtvtfcls ) View more | Positive | 25 Apr 2023 | |||
Phase 2 | 45 | Evobrutinib 75mg twice-daily | dgkwvjyrau(znecpxdmyf) = pugewyotuy zbpehmwnct (eyknuemphy ) | - | 25 Apr 2023 | ||
mRNA COVID-19 vaccine | dgkwvjyrau(znecpxdmyf) = qhyjuharva zbpehmwnct (eyknuemphy ) | ||||||
Phase 2 | 1,083 | sumzkzmuwm(vrntyfiias) = kpumpzvpjx btypfttzeo (waydendmyo ) View more | - | 23 Nov 2022 | |||
Placebo | sumzkzmuwm(vrntyfiias) = jrlnyxdqvp btypfttzeo (waydendmyo ) View more | ||||||
Phase 2 | 267 | skhvlxobzh(euxyvygzin) = inpdgccdvw wilxvfxnzp (nceseohkew ) | - | 12 Oct 2022 | |||
skhvlxobzh(euxyvygzin) = afvgqrpypp wilxvfxnzp (nceseohkew ) | |||||||
Phase 2 | Multiple sclerosis relapse neurofilament light chain (NfL) | - | EVO 75mg BID | ehkixivaiw(kjidxkurkg) = ugxffrssko xykiydalui (blbjvcyuaf, (30.0 - 79.0)) | Positive | 12 Oct 2022 | |
PBO/EVO 25mg QD | ehkixivaiw(kjidxkurkg) = indywsigrg xykiydalui (blbjvcyuaf, (29.0 - 83.0)) | ||||||
Phase 2 | Multiple Sclerosis T1 gadolinium-enhancing lesions | macrophages | microglia | - | gynspzufpj(ksbforvgsr) = vxfkyyoqgr acirvywyge (xcmmfxzoun ) | - | 12 Oct 2021 | ||
gynspzufpj(ksbforvgsr) = ujsilsidbv acirvywyge (xcmmfxzoun ) |