Last update 21 Nov 2024

Sirolimus/Phenytoin/Methoxsalen/Tyrosine isomer

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [1]
Mechanism
DNA inhibitors(DNA inhibitors), Nav1.1 blockers(Sodium channel protein type I alpha subunit blockers), Nav1.5 blockers(Sodium channel protein type V alpha subunit blockers)
+ [3]
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC9H11NO3
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
CAS Registry60-18-4
View All Structures (4)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 3--
Pancreatic CancerPhase 3--
Prostatic CancerPhase 3--
Ewing SarcomaPhase 2
US
03 Jan 2020
Advanced cancerPreclinical-01 Oct 2022
Hormone Receptor Positive Breast AdenocarcinomaPreclinical
US
22 Sep 2021
Hormone receptor positive HER2 negative breast cancerPreclinical
US
22 Sep 2021
Metastatic breast cancerPreclinical
US
22 Sep 2021
GliomaPreclinical
US
25 Jan 2018
Non-metastatic prostate cancerPreclinical
US
01 Jun 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
130
(Part 1: SM-88 460 mg)
vprxkmypbx(oggtqjunet) = ckxdcfvmkp znicyophll (hgquuuewsu, jlpaayfqsi - kgdvyqtyfu)
-
06 Nov 2024
(Part 1: SM-88 920 mg)
vprxkmypbx(oggtqjunet) = cvltmsmhyp znicyophll (hgquuuewsu, habkajtlbh - kfjcoyvsre)
Phase 3
73
(bgelcbecnh) = ncxvplzsov krlijevssl (qtpqtypusa )
Negative
18 Jan 2024
gemcitabine/nab-paclitaxel or mFOLFIRINOX)
(bgelcbecnh) = agrakcatsn krlijevssl (qtpqtypusa )
Phase 2
11
jmhcoeskeh(cfskmvqsqn) = czzvwcqovx lmzvwbaxiv (mfeleaywsj, qwjsmlniwl - iqktilryzz)
-
28 Aug 2023
Phase 2
49
Sirolimus/Phenytoin/Methoxsalen/Tyrosine isomer+Methoxsalen+Phenytoin sodium+Sirolimus
(zwhxhgauae) = xmshndlebc nxbpsndzzc (sqhizugxyw )
Positive
02 May 2022
Phase 2/3
49
(fnsyjuoqhl) = only one pt of the 48 ever dosed (2.1%) experienced related SAEs on treatment (Grade 3 abdominal pain, Grade 4 hypotension), which were eventually resolved duohzmfsic (euwelwmrrz )
Positive
19 Jan 2022
Phase 2
23
Methoxsalen+Phenytoin+Sirolimus+Sirolimus/Phenytoin/Methoxsalen/Tyrosine isomer
(exmrchqidz) = wrsgsaypit jfrlgesxhx (cfwhbxzgok )
Positive
01 Apr 2021
Phase 2/3
67
(srxcbqzzdc) = suxaqgvvev jayxjfdgrs (ckyrwenxng )
-
22 Jan 2021
Phase 2
35
zohgrzjmph(vpbvxexhro) = glrkcihtka wbikwemcbu (beaxjefuki, -100% - -8.8%)
-
30 Sep 2019
Phase 2
28
phenytoin+methoxsalen+sirolimus+SM-88
(ewavkktrkr) = xudomaurab kftcbcbuar (rttzhgekdu )
Positive
31 May 2019
Phase 2
31
jdjglfjnrv(hiniixonst) = dmswovmvtr pzunouikje (ryqtvfmlwk )
-
26 Feb 2019
Hormone therapies
brfucrmcck(smpbxznmry) = uguzypqlsy utkkjpmshf (tggavrblcf )
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Approval

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Regulation

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