A Double-Blind, Randomized, Placebo-Controlled, Single Center Study to Assess the Angiogenesis and Blood Perfusion Effect of NL003 in Patients With Critical Limb Ischemia by PETCT-RGD and MIBI

The purpose of this study is to evaluate whether PET/CT-RGD or MIBI can be used for the angiogenesis assessment of NL003 in PAD patients.

Start Date29 Jul 2022

Sponsor / Collaborator

Beijing Northland Biotech.Co., Ltd.

CTR20221646

/ CompletedPhase 3

联合 68Ga-RGD PET 和 99mTc-MIBI SPECT 影像学方法评估 NL003 在治疗慢性下肢缺血过程中对血管新生及下肢血流灌注量的影响，评价药物的有效性和安全性。

[Translation] Combined 68Ga-RGD PET and 99mTc-MIBI SPECT imaging methods were used to evaluate the effect of NL003 on angiogenesis and lower limb blood perfusion in the treatment of chronic lower limb ischemia, and to evaluate the efficacy and safety of the drug.

联合 68Ga-RGD PET 和 99mTc-MIBI SPECT 影像学方法评估 NL003 在治疗慢性下肢缺血过程中对血管新生及下肢血流灌注量的影响，评价药物的有效性和安全性。

[Translation]

Combined 68Ga-RGD PET and 99mTc-MIBI SPECT imaging methods were used to evaluate the effect of NL003 on angiogenesis and lower limb blood perfusion in the treatment of chronic lower limb ischemia, and to assess the efficacy and safety of the drug.

Start Date29 Jul 2022

Sponsor / Collaborator

Beijing Northland Biotech.Co., Ltd.

NCT05176093

/ CompletedPhase 2

A 6-Month Extension Study Following Protocol VMALS-002-2 (A Phase 2a, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis)

The purpose of this study is to evaluate the long-term safety of intramuscular (IM) administration of Engensis in Participants with Amyotrophic Lateral Sclerosis (ALS) who were previously randomized, received treatment, and completed the Day 180 Visit of Study VMALS-002-2. Safety will be assessed by incidences of treatment-emergent adverse events (TEAEs), treatment emergent serious adverse events (TESAEs), adverse events of special interest (AESIs), and the clinically significant laboratory values. See the table below for additional, exploratory endpoints.

Start Date14 Nov 2021

Sponsor / Collaborator

Helixmith Co., Ltd.

100 Clinical Results associated with Donaperminogene seltoplasmid(Viromed)

100 Translational Medicine associated with Donaperminogene seltoplasmid(Viromed)

100 Patents (Medical) associated with Donaperminogene seltoplasmid(Viromed)

228

Literatures (Medical) associated with Donaperminogene seltoplasmid(Viromed)

01 Jan 2025·JOURNAL OF VASCULAR SURGERY

HEPATOCYTE GROWTH FACTOR FOR WALKING PERFORMANCE IN PERIPHERAL ARTERY DISEASE

Article

Author: Sufit, Robert ; Parekh, Nishant D ; Kramer, Christopher M ; Ferrucci, Luigi ; Tian, Lu ; Domanchuk, Kathryn J ; Peterson, Charlotte A ; Zhao, Lihui ; Volpe, Nicholas J ; Ismaeel, Ahmed ; Polonsky, Tamar ; Zhang, Dongxue ; McDermott, Mary M ; Ho, Karen ; Xu, Shujun ; Kosmac, Kate ; Lloyd-Jones, Donald ; Guralnik, Jack M ; Leeuwenburgh, Christiaan ; Kibbe, Melina R ; Criqui, Michael H

INTRODUCTION:

VM202 is a plasmid encoding two isoforms of hepatocyte growth factor (HGF). In preclinical studies, HGF stimulated angiogenesis and muscle regeneration. This preliminary clinical trial tested the hypothesis that VM202 injections in gastrocnemius muscle would improve walking performance in people with mild to moderate and symptomatic lower extremity peripheral artery disease (PAD).

METHODS:

In a double-blind clinical trial, people with PAD were randomized to gastrocnemius muscle injections of either 4 mgs of VM202 or placebo every 14 days for four doses. The primary outcome was 6-month change in 6-minute walk distance. Secondary outcomes included 3-month change in treadmill walking time and gastrocnemius muscle biopsy measures. In this preliminary trial, statistical significance was pre-specified as a one-sided P value <0.10.

RESULTS:

39 participants with PAD (64.1% Black, 28.2% female) were randomized. Adjusting for age, race, smoking, and baseline performance, VM202 did not improve 6-minute walk at 6-month follow-up, compared to placebo (-13.5 meters, 90% confidence interval (CI): -38.5,+∞). At 3-month follow-up, VM202 improved maximum treadmill walking time (+2.38 minutes (90% CI: +1.08, +∞), P=0.014) and increased central nuclei abundance in gastrocnemius muscle (+5.86, 90% CI: +0.37,+∞, P=0.088), compared to placebo. VM202 did not significantly improve pain-free walking distance (difference: +0.30 minutes, 90% CI:-1.10,+∞, P=0.39), calf muscle perfusion (difference: +1.80 ml/minute per 100 g tissue, 90% CI: -3.80,+∞, P=0.33), or the WIQ distance score (difference: +2.02, 90% CI: -8.11,+∞, P=0.40). In post-hoc analyses, VM202 significantly improved 6-minute walk in PAD participants with diabetes mellitus at 6-month follow-up (+34.19 (90% CI: 4.04,+∞), P=0.075), but had no effect in people without diabetes (interaction P value=0.079).

CONCLUSIONS:

These data do not support gastrocnemius injections of VM202 to improve 6-minute walk in PAD. Secondary outcomes suggested potential benefit of VM202 on skeletal muscle measures and treadmill walking, while post-hoc analyses suggested benefit in PAD participants with diabetes.

01 Nov 2024·EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Recombinant Human Hepatocyte Growth Factor Plasmids for Treating Patients with Chronic Limb Threatening Ischaemia: A Systematic Review and Meta-analysis

Review

Author: Ni, Leng ; Di, Xiao ; Liu, Chang-Wei ; Wang, Peng ; Li, Fengshi ; Han, Wei

OBJECTIVE:

Recombinant human hepatocyte growth factor (HGF) plasmids are novel alternatives to salvage limbs in patients with chronic limb threatening ischaemia (CLTI). A systematic review and meta-analysis of data was conducted to assess the therapeutic efficacy of HGF plasmids in patients with CLTI.

DATA SOURCES:

Randomised controlled studies evaluating HGF plasmid efficacy in patients with CLTI were identified using MEDLINE, Embase, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov databases.

REVIEW METHODS:

Meta-analyses of the reported relative risk (RR) or mean difference (MD) were conducted. Subgroup analyses were performed to determine the efficacy of HGF plasmids in cohorts excluding Buerger's disease. Certainty of evidence for each outcome was assessed.

RESULTS:

Seven studies (n = 655 participants) were included. Based on low certainty evidence, patients treated with HGF had a significantly higher complete ulcer healing rate (RR 1.99, 95% confidence interval [CI] 1.30 - 3.04; p = .002) than patients treated with placebo. HGF treatment was associated with reduced visual analogue scale (VAS) scores of pain severity (MD -1.56, 95% CI -2.12 - -1.00; p < .001) vs. placebo in patients with CLTI assessed at three month follow up (low certainty evidence); no significant differences were observed in major amputation (RR 0.91, 95% CI 0.48 - 1.73; p = .77) (low certainty evidence) or all cause mortality rate (RR 0.93, 95% CI 0.38 - 2.27; p = .87) (low certainty evidence) between patients treated with HGF and placebo. Low certainty evidence suggested no significant differences in change in ankle brachial index at six months (MD 0.00, 95% CI -0.09 - 0.09; p = 1.0) between patients treated with HGF and placebo. The complete ulcer healing rate and improved three month VAS scores of pain severity benefits persisted in subgroup analyses (low certainty evidence).

CONCLUSION:

Low certainty evidence suggested that HGF treatment is associated with an increased complete ulcer healing rate and reduced ischaemic pain in patients with CLTI.

01 Nov 2024·GENE

HGF ameliorates cardiomyocyte apoptosis and inflammatory response in sepsis via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway

Article

Author: Su, Li-Ye ; Lao, Jian-le ; Huang, Zhao-He ; Liang, Liu-Dan ; Liu, Yan ; Huang, Mei-Jin ; Huang, Jia-Wei ; Peng, Hui-Xin

OBJECTIVE:

This study aimed to analyze the impact of HGF on cardiomyocyte injury, apoptosis, and inflammatory response induced by lipopolysaccharide (LPS).

METHODS:

Enzyme-linked immunosorbent assay (ELISA) was utilized to quantify the levels of HGF, interleukin (IL)-6, IL-10, creatine phosphokinase-isoenzyme-MB (CK-MB), and cardiac troponin I (cTnI) in the samples. qPCR and Western blotting (WB) were employed to assess the mRNA and protein expressions of HGF, IL-10, IL-6, PI3K, AKT, p-PI3K, and p-AKT.

RESULTS:

The outcomes of the in vivo experiment revealed that serum levels of IL-6, IL-10, HGF and SOFA scores in the SC group were elevated in contrast to the non-SC group. The correlation analysis indicated a substantial and positive association among serum HGF, IL-6, and IL-10 levels and SOFA scores. Relative to IL-6, IL-10 levels, and SOFA scores, serum HGF demonstrated the highest diagnostic value for SC. Following LPS administration to stimulate H9c2 cells across various periods (0, 12, 24, 48, and 72 h), the levels of myocardial injury markers (CK-MB and cTnI) in the cell supernatants, intracellular inflammatory factors (mRNA and protein levels of IL-10 and IL-6), apoptosis and ROS levels, exhibited a gradual increase followed by a subsequent decline. Following the overexpression of HGF, there was an increase in cell viability, and a decrease in apoptosis, inflammation, oxidative stress injuries, and the protein phosphorylation expressions of PI3K and AKT. After knockdown of HGF expression, the activity of LPS-induced H9c2 cells was further reduced, leading to increased cell injury, apoptosis, inflammation, oxidative stress,and the expression levels of PI3K and Akt protein phosphorylation were further elevated.

CONCLUSION:

HGF was associated with decreased LPS-induced H9c2 apoptosis and inflammation in H9c2 cells, alongside an improvement in cell viability, indicating potential cytoprotective effects. The mechanism underlying these impacts may be ascribed to the suppression of the PI3K/AKT signaling pathway.

News (Medical) associated with Donaperminogene seltoplasmid(Viromed)

04 Oct 2022

·www.prnewswire.com

Helixmith to Present New ALS-Focused Development Program at Upcoming Conferences

LA JOLLA, Calif., Oct. 4, 2022 /PRNewswire/ -- Helixmith announced today that their CEO, Dr. Sunyoung Kim, will be presenting an overview of their ALS-focused program, named DART, Defeating ALS through Regenerative Therapeutics, at both the 2022 Cell & Gene Meeting on the Mesa and the 2022 BIO-Europe Conference. DART is unique in that it capitalizes on cell signaling pathways important in ALS pathogenesis and that three modalities are being investigated virtually simultaneously for ALS. The first DART platform utilizes HGF/c-Met signaling pathway. Hepatocyte Growth Factor (HGF) is a multifunctional factor associated with neurotrophic, anti-fibrotic, anti-inflammatory and angiogenic activities. Its receptor, c-Met, is present in all major cell types important in ALS, including motor neurons, inflammatory macrophages, and skeletal muscles (such as the diaphragm and accessory muscles of respiration). Data from pre-clinical research demonstrated that HGF/c-Met signaling could produce strong anti-neuroinflammatory effects as well as promote axon outgrowth and motor neuron survival, restoring damaged upper and spinal motor neurons (UMN, SMN) and neuromuscular junction (NMJ), and improve muscle atrophy and motor functions. The rationale of such a multi-modal parallel approach is as follows: First, the cause of most ALS cases is unknown. Therefore, it is unlikely that the deployment of a single molecule (whether it be a small molecule or a biologic) will effectively treat all ALS cases, even if it were to work for a subset of patients. Helixmith is hence using an HGF that binds to key cell types involved in ALS pathogenesis, including motor neurons, macrophages, and skeletal muscles. Second, it takes nearly 10 years to develop one drug candidate and have it tested in a phase 1 clinical trial. If Helixmith was to start working on the second product only after the first candidate fails, this is too slow for ALS patients' urgent need for treatment. Therefore, Helixmith is testing three products almost simultaneously. Their aim is to get the results from the three clinical programs, including the phase 1 and phase 2 trials, within 5 years. In DART, three modalities (plasmid DNA, AAV, and humanized antibodies) are being investigated, in parallel, at both clinical and pre-clinical stages. Helixmith recently completed a Phase 1 and a Phase 2a clinical trial using Plasmid DNA-encoding HGF modality (Engensis or VM202). A small-scale phase 1/2 is planned in which plasmid DNA will be injected into the muscles involved in respiration, including the diaphragm. Having obtained encouraging data on survival rates, motor neuron function, and motor function in animal models, an optimized AAV vector modality (NM301) has also been developed for clinical studies. Additionally, a fully humanized antibody modality (VM507) that binds to c-Met receptors and activates signaling has shown its effectiveness in a variety of disease models. The AAV and antibody modalities will be tested in phase 1 studies between 2024 and 2026. Helixmith has the funding for a clinical study testing the effect of VM202 on respiration in ALS patients. To achieve their goal to complete clinical studies with two other modalities, Helixmith will need to raise additional capital. The following are specific details regarding Helixmith's presentation at the two conferences: Dr. Kim's Presentation is available on-demand to conference registrants at . About Helixmith Helixmith is a clinical-stage gene therapy company headquartered in Seoul, Korea, developing new and innovative biopharmaceuticals to address previously untreated diseases, and is listed on the KOSDAQ. The company has an extensive gene therapy pipeline including a CAR-T program targeting several different types of solid tumors and an AAV vector program targeting neuromuscular diseases. Engensis (VM202), the most advanced pipeline candidate, is a plasmid DNA therapy being studied for diabetic foot ulcers (DFU), claudication, amyotrophic lateral sclerosis (ALS), and diabetic peripheral neuropathy (DPN). Media Contact: Jennifer Guzman [email protected] 7602917245 SOURCE Helixmith USA Inc.

Gene TherapyAntibodySmall molecular drug

06 Sep 2022

·www.prnewswire.com

Helixmith Announces Topline Results from Phase 2A Study of Engensis for Treatment of ALS (Amyotrophic Lateral Sclerosis)

LA JOLLA, Calif., Sept. 6, 2022 /PRNewswire/ -- Helixmith announced topline results today from a Phase 2A study in individuals with ALS (Amyotrophic Lateral Sclerosis). ALS is a fatal neurodegenerative disorder of upper and lower motor neurons that causes progressive paralysis and eventual death due to respiratory failure. This Phase 2A was a double-blind placebo controlled multi-center study involving 5 sites (4 in the US and 1 in Korea) and 18 subjects randomized to a 2:1 ratio of Engensis to placebo. In this Phase 2A study, three treatments of Engensis, a plasmid DNA encoding human HGF, or placebo were injected in the upper and lower limbs on months 0, 2 and 4. One treatment consisted of two cycles of injections, on 2-week intervals, of 64 mg of Engensis or placebo in total. Therefore, a total of 192 mg of Engensis was given to each subject over a 4-month period. In addition, there was a follow-up period of 6 months after the first injection on Day 0. The results of the study demonstrated that Engensis was safe and well tolerated at this dosing regimen. There was no difference in the frequency of TEAEs (83% for each group) between the Engensis and the placebo groups. One TEAE, bronchitis, was reported in the Engensis group but was determined to not be related to the study drug. Injection site reactions were reported by 50% of the Engensis group and by 66.7% of the placebo group. Most of the injection site reactions were Grade 1 or 2 and resolved within a short time, and none of the participants in the study discontinued due to the number of injections. These data suggest that high dose, repeated treatments of Engensis, were safe and well tolerated, providing a great deal of flexibility in designing dosing schemes for future clinical studies. Given the primary endpoint of this study was to test safety and tolerability, efficacy was measured only as an exploratory parameter. ALSFRS-R scores, muscle functions using handheld dynamometry, and ALSAQ-40 were among the measurements collected. Since the study size was small and 4 subjects dropped out early, we were unable to compare efficacy between the Engensis and placebo groups. An important component of this study was the collection of biopsy samples from the participants' injections sites. Engensis is an intramuscularly delivered gene therapy. The bulk of the data collected to date, showing effects of HGF expressed from Engensis, has been from animal models. Data collected from clinical trials has been limited thus far. Thanks to our dedicated clinical trial participants, muscle biopsy samples were collected during the course of the trial and will be subjected to histological and molecular biological analyses using RNA-Seq. Helixmith greatly appreciates the generous and eager participation of the ALS patients. Data from these results are expected to provide valuable information on the understanding of the mechanisms of actions of Engensis, and its effects on the expression of human genes, which will greatly help in the development of innovative medicines based on HGF/c-Met signaling. Helixmith will continue the analysis of the Phase 2A data upon the receipt of the full report and plan to present results at a future conference and determine next steps for Engensis in ALS at that time. About Helixmith Helixmith is a clinical-stage gene therapy company headquartered in Seoul, Korea, developing new and innovative biopharmaceuticals to address previously untreated diseases, and is listed on the KOSDAQ. The company has an extensive gene therapy pipeline, including a CAR-T program targeting several different types of solid tumors and an AAV vector program targeting neuromuscular diseases. Engensis (VM202), the most advanced pipeline candidate, is a plasmid DNA therapy being studied for painful diabetic peripheral neuropathy, diabetic foot ulcers, claudication, amyotrophic lateral sclerosis, coronary artery disease, and Charcot-Marie-Tooth disease. SOURCE Helixmith USA Inc.

Gene Therapy

14 Mar 2022

·www.biospace.com

Paper Reporting Results from Helixmith's Phase 3 Gene Therapy Trial for Painful Diabetic Neuropathy was One of the Top-10 Most-Downloaded Articles in Clinical and Translational Science

Helixmith announced today that their publication, "Gene therapy for diabetic neuropathy: A randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor," was one of the top-10 most-downloaded articles in Clinical and Translational Science (CTS) in 2021. CTS is the official publication of the American Society for Clinical Pharmacology & Therapeutics (ASCPT) and highlights original research that helps bridge laboratory discoveries with the diagnosis and treatment of human diseases. Dr. John Kessler, Professor of Neurology at Northwestern was the lead author on this study. This was the first gene therapy phase 3 that has ever been done for pain. According to Alethea Gerding, Managing Editor, ASCPT, "The article has been downloaded more than 3,000 times, meaning that it has reached a wide-ranging worldwide readership. The primary goal of CTS is to become the beacon of translational science, and articles such as yours clearly show the value of translational science." According to Alethea Gerding, Managing Editor, ASCPT, "The article has been downloaded more than 3,000 times" In the paper, VM202 (donaperminogene seltoplasmid), a plasmid DNA encoding the human HGF (hepatocyte growth factor) gene, developed by Helixmith Co. Ltd, authors reported that in VMDN-003b, intramuscular injections of VM202 provided pain reduction for more than 8 months after the last cycle of treatment and that the safety and tolerability was highly favorable, consistent with previous studies. One of the most clinically important findings in both VMDN-003b and the phase II study is that VM202 was more effective in subjects not on pregabalin or gabapentin, two of the most prescribed medicine in the DPN field. These results have important clinical implications as more than 4.2 million people in the US are known to suffer from painful DPN and nearly 1.3 million patients are considered to be refractory, meaning currently available medications do not work for them (Painful Diabetic Neuropathy, GlobalData 2018). Helixmith launched a second phase 3 trial for DPN, REGAiN-1A (VMDN-003-2), in the US and are targeting release of top line results by the end of 2022. The company is planning to start a third phase 3 for DPN in the second half of 2022.

Donaperminogene seltoplasmid(Viromed)Helixmith Co., Ltd.Diabetic NeuropathiesGene Therapy

100 Deals associated with Donaperminogene seltoplasmid(Viromed)

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Lower limb ischemia	NDA/BLA	CN	Beijing Northland Biotech.Co., Ltd.	15 Jul 2024
Lower limb ischemia	NDA/BLA	CN	Jiangsu Yaohai Biological Pharmaceutical Co., Ltd.	15 Jul 2024
Diabetic peripheral neuropathic pain	Phase 3	US	Helixmith Co., Ltd.	20 Nov 2020
Chronic Limb-Threatening Ischemia	Phase 3	CN	Beijing Northland Biotech.Co., Ltd.	02 Aug 2019
Ulcer	Phase 3	CN	Beijing Northland Biotech.Co., Ltd.	02 Aug 2019
Diabetic foot ulcer	Phase 3	US	Helixmith Co., Ltd.	27 Jun 2017
Peripheral Arterial Disease	Phase 3	US	Helixmith Co., Ltd.	27 Jun 2017
Diabetic Nephropathies	Phase 3	CN	Beijing Northland Biotech.Co., Ltd.	-
Diabetic Nephropathies	Phase 3	-	Viromed, Inc.	-
Rest pain	Phase 3	CN	Beijing Northland Biotech.Co., Ltd.	-

Clinical Result

Indication

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04469270 (REGAiN-1A, CTgov)	Phase 3	Diabetic peripheral neuropathic pain	162	Engensis (Engensis)	ynaxvaiwvu(qvtylrduet) = pnajxzrfzw olrvnzqcse (rnrtpznyde, rkthzreqly - ljkpsrgtbt) View more	-	20 Jan 2025
				Placebo (Placebo)	ynaxvaiwvu(qvtylrduet) = qtsnbntvra olrvnzqcse (rnrtpznyde, uiiqyttdfo - okojlkydtu) View more
NCT04873232 (REGAiN-1B, CTgov)	Phase 3	Diabetic peripheral neuropathic pain	106	Engensis (Engensis)	detfzhiqpl(bmzgrgpwdr) = wgwoelalvg bbculcqwof (bqyzxmhadi, cgoqhvdnlr - erovbenikt) View more	-	16 Jan 2025
				Placebo (Placebo)	detfzhiqpl(bmzgrgpwdr) = ovsrikpqef bbculcqwof (bqyzxmhadi, zzyegncdem - ptosqgtduz) View more
NCT00696124 (CTgov)	Phase 1	Chronic Limb-Threatening Ischemia \| Lower limb ischemia	12	VM202 2 mg (Cohort 1)	idoiusogux(uywztiwmbb) = duoxysmsyc pacczptyxb (mwigiwqsjt, skxepmelhf - oboqfansgz) View more	-	18 Oct 2024
				VM202 4 mg (Cohort 2)	idoiusogux(uywztiwmbb) = zeweyxxrro pacczptyxb (mwigiwqsjt, uleamuxqyj - cxxmsovwaf) View more
NCT01064440 (CTgov)	Phase 2	Chronic Limb-Threatening Ischemia	52	Placebo	lbuvhvhvlu(vsvvhsomml) = aizfjwxcky bjbaipoqdo (hmzoouuybh, aoafjnkzyq - ungblhkkyx) View more	-	19 Sep 2024
NCT03363165 (HI-PAD, CTgov)	Phase 2	Peripheral Arterial Disease	39	Placebo (Placebo)	epzzhndtnr(qbrktfifok) = prwuzsaviy nhhljjcubi (ogctwbobnm, qfriewytfl - rbaklstcsp) View more	-	30 May 2024
				VM202 (VM202)	epzzhndtnr(qbrktfifok) = rfsvpjwsfx nhhljjcubi (ogctwbobnm, susoxtadht - rqhopwznfo) View more
NCT04274049 (NL003-CLI-III-2, Corporate Publications) Manual	Phase 3	Lower limb ischemia	242	NL003	jzgjvkgfuy(xanojkolej): P-Value = <0.0001 Met	Positive	02 Feb 2024
				Normal Saline
NCT01475786 (CTgov)	Phase 2	Diabetic peripheral neuropathy	104	High Dose: 32 mg Engensis (VM202) (High Dose 32mg Engensis (VM202))	dmmfattslo(ilolhizvty) = jcgpdmvrgt hisqtmvjsd (vedmglgmtt, cdpjauvpsf - zbgisxatdu) View more	-	03 Jul 2023
				Control- Placebo (normal saline)+Low Dose: 16 mg Engensis (VM202) (Low Dose 16mg Engensis (VM202) and Placebo)	dmmfattslo(ilolhizvty) = vthitwfyqs hisqtmvjsd (vedmglgmtt, jpdfyxejnt - oxrgnxzowk) View more
NCT04055090 (CTgov)	Phase 3	Diabetic peripheral neuropathy	101	Long-Term Follow-Up of Patients who Received Engensis (VM202) (Subjects Who Received Engensis (VM202))	iolwfwrhfh(jketberxtl) = eyzeypmzdm geczioevmg (idahqvjppt, yzasrfdjsn - hjzvjekyhi) View more	-	08 Mar 2023
				Long-Term Follow-Up of Patients who Received Placebo (Subjects Who Received Placebo)	iolwfwrhfh(jketberxtl) = mlhhbdsnto geczioevmg (idahqvjppt, zeocuzumav - dnwvtxpgvr) View more
NCT02563522 (CTgov)	Phase 3	Diabetic foot ulcer \| Peripheral Arterial Disease	44	Engensis (VM202) (Active)	czxhzioibr(jfizujmzci) = hratdsulnm ersymyifgw (neiucpdukq, mrlwqpntpr - rzbrlaixty) View more	-	22 Feb 2023
				Placebo (Control)	czxhzioibr(jfizujmzci) = iakmdoqwln ersymyifgw (neiucpdukq, crjhqeefky - yppujfzoem) View more
NCT05176093 (PRNewswire) Manual	Phase 2	Amyotrophic Lateral Sclerosis	18	Engensis	kchqsmzgka(pnrtqvjgqi) = etiiounabk anzdqmehmr (jwrbmvjoja ) View more	Positive	06 Sep 2022
				Placebo	kchqsmzgka(pnrtqvjgqi) = iwktjsvioh anzdqmehmr (jwrbmvjoja ) View more

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