A review. Thymosin β4 is widely distributed in invertebrates, which has numerous biol. effects, because of the function of actin polymerization and depolymerization Thymosin β4 can accelerate tissue regeneration and repair, and it has a great potential for development as a drug to promote wound healing, cornea repairing, and myocardial repairing. In recent years, published studies have described a number of physiol. properties about thymosin β4, and this review details the research progress and the drug discovery of thymosin β4.