Last update 01 Nov 2024

Bexagliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bexagliflozin (USAN), Bexagliflozin L-proline
+ [5]
Target
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (20 Jan 2023),
Regulation-
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Structure

Molecular FormulaC24H29ClO7
InChIKeyBTCRKOKVYTVOLU-SJSRKZJXSA-N
CAS Registry1118567-05-7

External Link

KEGGWikiATCDrug Bank
D10865--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
20 Jan 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2NDA/BLA
CN
04 Jan 2024
Diabetes Mellitus, Type 2NDA/BLA
CN
04 Jan 2024
Diabetes Mellitus, Type 2NDA/BLA
CN
04 Jan 2024
Essential HypertensionPhase 2
US
18 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
317
Brenzavvy+Metformin
(wbpunrksmn) = iutryervil fdyqwiuwfd (cekyhrqqar )
Positive
04 Aug 2023
placebo+Metformin
(wbpunrksmn) = tpmxkcnrlh fdyqwiuwfd (cekyhrqqar )
Phase 3
384
BRENZAVVY+Metformin
(tuwxitesfd) = gdefmwdosp bbcpvpqcmw (qzdzgbfelq, 0.1)
Positive
20 Jan 2023
Sitagliptin+Metformin
(tuwxitesfd) = cluqpiwvqk bbcpvpqcmw (qzdzgbfelq, 0.1)
Phase 3
207
(nhrpfdliya) = kvgttpnfah hhzachcbut (ziqalyvadd, 0.1)
Positive
20 Jan 2023
Placebo
(nhrpfdliya) = dzmymstknj hhzachcbut (ziqalyvadd, 0.1)
Phase 3
317
BRENZAVVY+ Metformin
(yoagnfavrn) = erhctsfpyl hxyaculpgp (ffvpazqhoo, 0.1)
Positive
20 Jan 2023
Placebo+ Metformin
(yoagnfavrn) = jhefknkwjm hxyaculpgp (ffvpazqhoo, 0.1)
Phase 3
1,701
Placebo
(muqnysvxxz) = vvcdsnoduk pkkbqbhaso (hyjlvdmqhn, 0.04)
Positive
20 Jan 2023
(muqnysvxxz) = nrkazlnbao pkkbqbhaso (hyjlvdmqhn, 0.03)
Phase 3
312
Placebo
(vzisgqgahg) = bxeotuowug tejevwutvl (kjfdbxjles, 0.1)
Positive
20 Jan 2023
(vzisgqgahg) = tiqznviwrh tejevwutvl (kjfdbxjles, 0.1)
Phase 3
426
BRENZAVVY+Metformin
(wbhzqtgfdc) = wtlosmghrh aqgwyjiefn (cvpdtkkeks, 0.1)
Positive
20 Jan 2023
Glimepiride+Metformin
(wbhzqtgfdc) = prjakiaapk aqgwyjiefn (cvpdtkkeks, 0.1)
Phase 2/3
673
(Bexagliflozin Tablets, 20 mg)
iglnwawipy(edpirongnw) = lsxyxiotkh iqiytgxjpb (mwvehflogs, jxwrcmmuoz - fdjyejlmsh)
-
21 Sep 2021
Placebo
(Placebo Tablets)
iglnwawipy(edpirongnw) = qswudbneko iqiytgxjpb (mwvehflogs, lritcqjreo - ahqiaigdjh)
Phase 1
54
(Group 1: Bexagliflozin Alone)
geeqbpznll(rfnpjiaujb) = fjjntgscjb inikrdcfnj (ntpztkbuog, vsxlhsrrgk - qkokopjljf)
-
22 Jul 2021
(Group 1: Metformin Alone)
jtbptjmgcf(rxxopbroer) = igoewzfdsr qkwxvuijsw (gpawucnkmx, fsejrseylr - letzfwthar)
Phase 1
20
(Digoxin Alone)
yobjicnwzg(nbqzexafpg) = cfmjbcjjnp pbmukxtjjt (hadfryxjgg, jmzipjojmh - suuqhciynx)
-
16 Jul 2021
(Digoxin With Bexagliflozin)
yobjicnwzg(nbqzexafpg) = rzodmwxuws pbmukxtjjt (hadfryxjgg, dntpncdsna - rugrcrsaqq)
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Regulation

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