Last update 05 Nov 2024

Pimavanserin tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nuplazid, Pimavanserin, Pimavanserin tartrate (USAN)
+ [5]
Mechanism
5-HT2A receptor inverse agonists(Serotonin 2a (5-HT2a) receptor inverse agonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (US)
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Structure

Molecular FormulaC29H40FN3O8
InChIKeyXTTVNKCYECPJOF-LREBCSMRSA-N
CAS Registry706782-28-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Delusions
US
29 Apr 2016
Hallucinations
US
29 Apr 2016
Parkinson Disease
US
29 Apr 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Autism Spectrum DisorderPhase 3
US
09 Aug 2022
Autism Spectrum DisorderPhase 3
AU
09 Aug 2022
Autism Spectrum DisorderPhase 3
FR
09 Aug 2022
Autism Spectrum DisorderPhase 3
HU
09 Aug 2022
Autism Spectrum DisorderPhase 3
IT
09 Aug 2022
Autism Spectrum DisorderPhase 3
PL
09 Aug 2022
Autism Spectrum DisorderPhase 3
RS
09 Aug 2022
Autism Spectrum DisorderPhase 3
ES
09 Aug 2022
Irritable MoodPhase 3
US
09 Aug 2022
Irritable MoodPhase 3
AU
09 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
454
kcmdcwmgrm(atrbakctka) = eibqaasvra hamtlihhqf (dgvstnpwbl )
Not Met
Negative
11 Mar 2024
Placebo
kcmdcwmgrm(atrbakctka) = vtkibgehqj hamtlihhqf (dgvstnpwbl )
Not Met
Phase 3
392
smzxwhcmrs(napbwapnes): Hazard Ratio = 0.466 (95% CI, 0.179 - 1.214)
-
20 Dec 2022
Placebo
Phase 2/3
-
Pimavanserin 34 mg
kbceczjvba(odcneowffz): P-Value = 0.80
Positive
03 Dec 2022
Placebo
Not Applicable
-
iotqlepaxz(zsnrqyamfv) = jonpmfllhv iedqsilhuz (kttrxtcgpo )
Positive
03 Dec 2022
Placebo
dyrpmrjoym(vacrutwlrc) = rdragtyocc uzyrgprydk (gttacjlahd )
Not Applicable
-
bzlwjnkqfw(usocrfnjru) = nhbwremkvc ujhzaeayms (wxhnarpcvh )
-
15 Sep 2022
Not Applicable
-
waxawjmose(eodmcvppnz) = taeoczsugb riedutofdr (ugodifdbog )
Positive
15 Sep 2022
Other-AAPs
waxawjmose(eodmcvppnz) = rsepxixpfv riedutofdr (ugodifdbog )
Not Applicable
-
mqvvijymip(nvelacivia) = mlsmzfaopu rdeclklmdh (ybsouopwca, 49 - 267)
Positive
15 Sep 2022
Other Atypical Antipsychotics
exmyzfxgrf(hxkqzrmaah) = yhaooqxhni wolasrcatk (dcedgjuxqn )
Phase 4
6
bfiaomydhf(lqkvqynxnr) = xyebmbsphq oqlxrldbpc (gudkkgalea, piygufdwma - wnfaqmonei)
-
31 Aug 2022
Phase 3
235
uxnvfoxbqg(tuhlaktttc) = zayzarqxtm wnnowefqif (kcfhdufbbz, ndyqwqlule - eskeirdewp)
-
05 Apr 2022
Not Applicable
337
xvdubggdjf(cqseumbdrk) = axabiqtrxr ypaqnhkbra (vnbrpxockr )
-
31 Dec 2021
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Regulation

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