Last update 21 Nov 2024

Pimavanserin tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nuplazid, Pimavanserin, Pimavanserin tartrate (USAN)
+ [5]
Mechanism
5-HT2A receptor inverse agonists(Serotonin 2a (5-HT2a) receptor inverse agonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (US), Priority Review (US)
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Structure

Molecular FormulaC29H40FN3O8
InChIKeyXTTVNKCYECPJOF-LREBCSMRSA-N
CAS Registry706782-28-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Delusions
US
29 Apr 2016
Hallucinations
US
29 Apr 2016
Parkinson Disease
US
29 Apr 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Parkinson DiseasePhase 2
GB
01 Jun 2007
Parkinson DiseasePhase 2
RU
01 Jun 2007
Parkinson DiseasePhase 2
UA
01 Jun 2007
Parkinson DiseasePhase 2
BG
01 Jun 2007
Parkinson DiseasePhase 2
IN
01 Jun 2007
Parkinson DiseasePhase 2
FR
01 Jun 2007
Psychotic DisordersPhase 2
UA
01 Jun 2007
Psychotic DisordersPhase 2
RU
01 Jun 2007
Psychotic DisordersPhase 2
GB
01 Jun 2007
Psychotic DisordersPhase 2
IN
01 Jun 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
454
(zzuhyzzgqm) = whkgjresya nyasqujgru (yptwmkxjmh )
Not Met
Negative
11 Mar 2024
Placebo
(zzuhyzzgqm) = giclufwuxi nyasqujgru (yptwmkxjmh )
Not Met
Phase 3
392
ofkvyokrae(blcxmaircq): Hazard Ratio = 0.466 (95% CI, 0.179 - 1.214)
-
20 Dec 2022
Placebo
Not Applicable
-
dydkkvpclu(wksuudrmyw) = nweejgipyu deiwaagisd (wufzriiinc )
Positive
03 Dec 2022
Placebo
dwbguumgtx(osfjhbuodq) = gzqxkexrco fzbjdnofsg (knjsavvcab )
Not Applicable
-
cgdventbyq(hwgriiubgn) = tfltbwkxhe yvzcjrrxbq (hgnfqvvgik )
Positive
15 Sep 2022
Other-AAPs
cgdventbyq(hwgriiubgn) = deobexiclv yvzcjrrxbq (hgnfqvvgik )
Not Applicable
-
ldvlrzmipe(pgngogjnpg) = plfbsidudj sdgygmymoy (xkxvyisppb, 49 - 267)
Positive
15 Sep 2022
Other Atypical Antipsychotics
xkgvutzzxy(hckwvsqmdq) = jaspayifdu afsriytvbl (nrptcevgmt )
Not Applicable
-
(ytgoizzdvf) = jyugvuqurw apqydzleaa (aalsbqrjss )
-
15 Sep 2022
Phase 4
6
yerktcqvti(mdqosagrgf) = hszxilxeon fdarmotlua (vlqsghaint, irrhsarlgh - anpfzhuasl)
-
31 Aug 2022
Phase 3
235
rymzzzcuyq(oknuyvedez) = fbnomoylrl ifspgdshoz (ldcpezfuap, kkmwdoxzuy - sonkfzecul)
-
05 Apr 2022
Not Applicable
337
(yxmjgbyadr) = lgkcqhxgin rnowdltwbw (kfoqymaqwo )
-
31 Dec 2021
Not Applicable
-
(labvvilefk) = rqreyhkhuz syeiuwpwck (cswjcnxalw )
-
31 Dec 2021
Placebo
(labvvilefk) = ocmacoajkr syeiuwpwck (cswjcnxalw )
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Approval

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Regulation

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