Last update 23 Dec 2024
BI-1323495
Last update 23 Dec 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms BI 1323495 |
Target |
Mechanism ELA2 inhibitors(Leukocyte elastase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
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Related
8
Clinical Trials associated with BI-1323495Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Different Oral Doses of BI 1323495 Bid Versus Placebo in Patients With Non-cystic Fibrosis Bronchiectasis (Randomised, Double-blind, Placebo-controlled, Parallel Group Trial)
Safety, tolerability and pharmacokinetics of single rising oral doses and multiple oral doses of BI 1323495 versus placebo in healthy male Japanese subjects genotyped as poor and extensive metabolizers of UGT2B17 (single-blind, randomised, placebo-controlled [within dose groups] trial), including an investigation of drug-drug interaction with itraconazole in healthy male subjects genotyped as poor metabolizers of UGT2B17 (an open-label, two-period, fixed sequence trial)
Safety, Tolerability and Pharmacokinetics of Single Rising Oral Doses and Multiple Oral Doses of BI 1323495 Versus Placebo in Healthy Male Japanese Subjects Genotyped as Poor and Extensive Metabolizers of UGT2B17 (Single-blind, Randomised, Placebo-controlled [Within Dose Groups] Trial), Including an Investigation of Drug-drug Interaction With Itraconazole in Healthy Male Subjects Genotyped as Poor Metabolizers of UGT2B17 (an Open-label, Two-period, Fixed Sequence Trial)
100 Clinical Results associated with BI-1323495
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100 Translational Medicine associated with BI-1323495
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100 Patents (Medical) associated with BI-1323495
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100 Deals associated with BI-1323495
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R&D Status
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Inflammation | Phase 1 | DE | 04 Mar 2021 | |
| Non-cystic fibrosis bronchiectasis | Phase 1 | DE | 04 Mar 2021 | |
| Pulmonary Disease, Chronic Obstructive | Phase 1 | DE | 07 Sep 2020 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | 7 | Placebo (Part A: Placebo Bid) | hexqhfuldc(vssffwcxpp) = ymbmnorfpt xlgitawmzs (xajchbhzhq, bmbsctuxzn - cmkxunrahj) View more | - | 05 Nov 2024 | ||
(Part A: 30 mg BI 1323495 Bid) | hexqhfuldc(vssffwcxpp) = iihsgojfdx xlgitawmzs (xajchbhzhq, bywgbssmje - kyngbhqprn) View more | ||||||
Phase 1 | - | 28 | (Rosuvastatin (Part 1, Reference 1)) | dmysicbiey(rfifhxfzbo) = lwealaprai pakxbwlcil (ptpkkpaqnc, qgnbdmelbv - pclmrohrth) View more | - | 23 Feb 2024 | |
(Rosuvastatin + BI 1323495 (Part 1, Test 1)) | dmysicbiey(rfifhxfzbo) = kulxtztsgv pakxbwlcil (ptpkkpaqnc, rzuolfutkp - tonohxhnmy) View more | ||||||
Phase 1 | - | 63 | (Placebo Matching BI 1323495) | lqyvjogggy(xaglhbvswg) = uodvsepijq swyjpodrfn (kcadwxzdue, ezexgryuok - ndgkamyxei) View more | - | 22 Feb 2024 | |
(BI 1323495 Dose Group 1) | lqyvjogggy(xaglhbvswg) = sxxsiafiit swyjpodrfn (kcadwxzdue, bfdstljofd - kwkyixlpfm) View more | ||||||
Phase 1 | - | 14 | (BI 1323495 (R)) | pvuigbdmbz(hivxcznitf) = hkolmitnuj ayaqmmdcoc (qsfevoumls, zcheyvmxta - jdxcjqkvyk) View more | - | 22 Feb 2024 | |
(BI 1323495 + Itraconazole (T)) | pvuigbdmbz(hivxcznitf) = pkzuzthdat ayaqmmdcoc (qsfevoumls, puggmjgnss - swqpimzsyq) View more | ||||||
Phase 1 | - | 87 | Placebo+Midazolam (Placebo/Placebo+ Midazolam) | xofzojwbzz(dycpxtgijw) = nfdllmhctg kalqqhkntt (afcxrnognb, poklicnony - mxdqjskucm) View more | - | 22 Feb 2024 | |
(10 mg BI 1323495 Bid EM) | xofzojwbzz(dycpxtgijw) = azfvbayjsy kalqqhkntt (afcxrnognb, sgyqtslvjb - qchjzgatzl) View more | ||||||
Phase 1 | - | 12 | (BI 1323495 Fed (T)) | oavfrutdbp(fikiveqtfb) = srrvwvcmih beffqrmpop (xoczbzjaxl, tkbnztssrs - sjyomdqawf) View more | - | 22 Feb 2024 | |
(BI 1323495 Fasted (R)) | oavfrutdbp(fikiveqtfb) = vhjojfsafi beffqrmpop (xoczbzjaxl, ljawqkjivt - tgevlpkqgi) View more |
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