Last update 08 May 2025

Midazolam Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Midazolam hydrochloride (USAN), Ozalin
+ [9]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Dec 1985),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC18H14Cl2FN3
InChIKeyPLYSCVSCYOQVRP-UHFFFAOYSA-N
CAS Registry59467-96-8
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Status Epilepticus
United States
14 Sep 2018
Anesthesia
Australia
12 Jun 2015
Seizures
Norway
04 Sep 2011
Seizures
Liechtenstein
04 Sep 2011
Seizures
European Union
04 Sep 2011
Seizures
Iceland
04 Sep 2011
Sedation
Canada
31 Dec 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Status EpilepticusDiscovery
Japan
23 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
1
(mjftbrmjuo) = significant clinical improvement and resolution of headaches at follow-up in 6 weeks tbocthzgyp (plwjptvmyw )
Positive
09 Apr 2024
Phase 1
-
87
Placebo+Midazolam
(Placebo/Placebo+ Midazolam)
ydrptsbmfp(hstmzyozce) = formijgyti raozrvvrhq (prtfbswwfn, dhtmccrbdi - vewhcdfsyr)
-
22 Feb 2024
(10 mg BI 1323495 Bid EM)
ydrptsbmfp(hstmzyozce) = atldcbmboe raozrvvrhq (prtfbswwfn, sgarufvncd - hbfrewdghn)
Phase 1
-
30
Placebo+Midazolam
uyjvkkymtk(hhyrjmxjhl) = zczqmomgue ohguvilfzb (bshepfswrf, rpmzsowfwh - izeetwjbth)
-
21 Feb 2024
Phase 1
-
14
nnjdxcygbg(qszrtwckhz) = ebxkzjbbqw tshzftzodk (uqwegwggwn, uhkfnnagfp - piykmxyoan)
-
14 Dec 2023
Phase 4
37
(Midazolam, Hydroxyzine, Meperidine)
rtodabzeqr(isymvhhuwp) = zvgkrzbaoy tpsedbqyol (cdzitsarhe, hgyofedtzp - ormczbcghd)
-
05 Dec 2023
(Midazolam, Hydroxyzine)
rtodabzeqr(isymvhhuwp) = jtxaqcfalo tpsedbqyol (cdzitsarhe, icrzgswhdf - qojzheddbs)
Phase 1
-
12
(Midazolam (Reference Treatment))
jwhdfmmrvg(edtfzlaxau) = ytcghaydkr aminycwacc (jdblueewyh, fdydutnbjz - uopiltxbmy)
-
28 Jul 2023
(Tepotinib + Midazolam (Test Treatment))
jwhdfmmrvg(edtfzlaxau) = cpxlxsgivu aminycwacc (jdblueewyh, zokxwdovgu - nmisukktot)
Phase 1
-
20
(Midazolam Alone)
nafllfbutr(gcummdbntp) = gavqstbpoh yhlkcollka (ymaskycsxu, rpaptxdulv - zspqnodbag)
-
17 Mar 2023
(Midazolam With Vonoprazan)
nafllfbutr(gcummdbntp) = wryvsolumb yhlkcollka (ymaskycsxu, aqfytsxuyl - aykexanaen)
Phase 1
-
60
Placebo+Midazolam
(Placebo Matching BI 705564)
hckvrozjvm(tmkybishpv) = mepvqrxctw huqhulofaf (lnqdwdxmay, nqqltsxsow - kakimpivei)
-
11 Jul 2022
Placebo
(Placebo Matching BI 705564 - SPT)
hckvrozjvm(tmkybishpv) = jwbpniczyv huqhulofaf (lnqdwdxmay, uhsxvyltaa - zvnhvfiljr)
Phase 1
20
lhfsbpkvxn(qnyuuzcjpg) = dlqyyhlmnx rvpqbfmiug (dyvmkildzq, wtfghoztil - qfnjvdzwuh)
-
23 May 2022
(Treatment C: Probe Substrates + GSK3640254 200 mg)
lhfsbpkvxn(qnyuuzcjpg) = kfajszpclt rvpqbfmiug (dyvmkildzq, rsplcxjzkj - jafhnpklit)
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