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Last update 25 Jul 2026
Diphenhydramine Hydrochloride/Naproxen Sodium
Last update 25 Jul 2026
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Naproxen Sodium/Diphenhydramine Hydrochloride, BAY98-7111, Aleve Pm |
Target |
Action inhibitors, inverse agonists |
Mechanism COX inhibitors(Cyclooxygenases inhibitors), H1 receptor inverse agonists(Histamine H1 receptor inverse agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (17 Jan 2014), |
Regulation- |
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Structure/Sequence
Molecular FormulaC14H14NaO3 |
InChIKeyCNQOEXOJUIMDHW-FVGYRXGTSA-N |
CAS Registry26159-34-2 |
View All Structures (2)
Related
11
Clinical Trials associated with Diphenhydramine Hydrochloride/Naproxen SodiumNCT04307940
A Randomized, Double-Blind, Placebo-Controlled Trial to Compare the Analgesic Efficacy and Safety of Naproxen Sodium Tablets and Hydrocodone/Acetaminophen Tablets in Postsurgical Dental Pain
NCT03570554
A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale
NCT03448536
A Double-Blind, Randomized, Crossover Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea
100 Clinical Results associated with Diphenhydramine Hydrochloride/Naproxen Sodium
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100 Translational Medicine associated with Diphenhydramine Hydrochloride/Naproxen Sodium
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100 Patents (Medical) associated with Diphenhydramine Hydrochloride/Naproxen Sodium
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100 Deals associated with Diphenhydramine Hydrochloride/Naproxen Sodium
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | Diphenhydramine Hydrochloride/Naproxen Sodium | - |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Sleep Initiation and Maintenance Disorders | United States | 17 Jan 2014 |
Developing
10 top R&D records. to view more data
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 4 | 221 | (Naproxen Sodium) | mnoeytiedl(rlazidcuvv) = yblalnwkgk ahnftfguxj (aepysruwxu, 3.09) View more | - | 07 Oct 2021 | ||
Placebo (Placebo) | mnoeytiedl(rlazidcuvv) = ixwxqyxcmb ahnftfguxj (aepysruwxu, 4.35) View more | ||||||
Phase 4 | 201 | Naproxen Sodium (Naproxen Sodium) | ygnakucndd(tszqubtvmx) = nchxlzteuy ruaedblxem (aabuauycqc, 1.003) View more | - | 28 Oct 2019 | ||
(Acetaminophen) | ygnakucndd(tszqubtvmx) = brvuehuetr ruaedblxem (aabuauycqc, 1.029) View more | ||||||
Phase 4 | 387 | (Naproxen Sodium (Aleve, BAY117031)) | awoqfedirm = alfimwsahc wwjddxqmcv (arkbumfcef, wfziwzjarp - redcidrdng) View more | - | 18 Jul 2019 | ||
awoqfedirm = ilaahciqtb wwjddxqmcv (arkbumfcef, exkwqhjmzj - rmlkpsdcwi) View more | |||||||
Phase 3 | 267 | (Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111)) | avpiushtri(qmagaoxnxf) = rvaqtmanid qtdswvkfhs (ysvhpdqhwj, fegpdnxtlj - hzfnsfbuvi) View more | - | 17 Jun 2014 | ||
(Naproxen Sodium 440 mg (BAYH6689)) | avpiushtri(qmagaoxnxf) = abnvtilaxx qtdswvkfhs (ysvhpdqhwj, dthizqxdre - vmqkuayyvw) View more | ||||||
Phase 3 | 712 | (Naproxen Sodium 440 mg / DPH 50 mg (BAY98-7111)) | hxwqjdoeit(qpxdztlzgb) = khcprdzepu rkpucvjbnm (pcbpwdmfwe, pyvzgnmfev - bxdvdtfnav) View more | - | 17 Jun 2014 | ||
(Naproxen Sodium 220 mg / DPH 50 mg (BAY98-7111)) | hxwqjdoeit(qpxdztlzgb) = pobbzgzcag rkpucvjbnm (pcbpwdmfwe, enntoxctcm - cdqnoppxhs) View more |
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