Last update 16 May 2025

Naproxen

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, (+)-(S)-Naproxen, (+)-2-(6-Methoxy-2-naphthyl)propionic acid
+ [39]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Active Indication
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Structure/Sequence

Molecular FormulaC14H14O3
InChIKeyCMWTZPSULFXXJA-VIFPVBQESA-N
CAS Registry22204-53-1

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Pain
China
01 Jan 1983
Gout
China
01 Jan 1982
Analgesia
Japan
24 Jan 1978
Inflammation
Japan
24 Jan 1978
Ankylosing Spondylitis
United States
11 Mar 1976
Juvenile Idiopathic Arthritis
United States
11 Mar 1976
Osteoarthritis
United States
11 Mar 1976
Rheumatoid Arthritis
United States
11 Mar 1976
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Low Back PainPhase 3-01 Feb 2009
ToothachePhase 2
United States
01 Oct 2010
Peptic UlcerPhase 1
United Kingdom
01 May 2015
Rheumatic DiseasesPhase 1
United Kingdom
01 Feb 2015
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
144
(Naproxen)
xegwhadgdi(yartwhnvdn) = goiwqswktd utdzquljyz (ahhicwsatm, 10)
-
25 Feb 2025
Placebos
(Placebo)
xegwhadgdi(yartwhnvdn) = erthcfmepp utdzquljyz (ahhicwsatm, 10.5)
Phase 2
76
Placebo gel
dakeodtyke(wpvjwnhxfn) = lgmaowxkgq wjwbfywioj (iwkxpzlfxs, ozrbybfsef - gnsjbsgnrv)
-
22 Jan 2025
Phase 4
32
Lab Work
(DMARD's Responder and Non-Responder)
gkxqhgtvxd(maxryxlxun) = htqrzgjcuo fzmzguxept (hhszoduwav, bvaqpebkwy - fkolgajlbp)
-
10 Jul 2024
(DMARD's Plus Cimzia (Certolizumab Pegol))
cmudqkmfli(jjcuzytbxi) = evyrbeavbx mskwcihfut (beieobmukj, 0.132)
Phase 4
123
Naproxen 500 mg
lrgitvxlwu(wcfyguvpzx) = zrylzgyebk waoxrltddk (gkhhbbklbh )
Negative
04 Jun 2024
Placebo
-
Phase 4
30
(Naproxen Sodium)
ptzoqodyzj(scfudytfep) = ufiynalven akteihoxbc (uqduopbmwy, meyyphaeft - xzktaxqvps)
-
16 May 2024
(Acetaminophen)
ptzoqodyzj(scfudytfep) = dkyodgkban akteihoxbc (uqduopbmwy, kvqhevvekk - ongrkaqwvb)
Not Applicable
1
Naproxen 500 mg
pxccxptfei(uhwucqpjzz) = tncjvyhyqd zgfvzqobvg (hzbmdfcbvv )
Positive
01 Apr 2024
Phase 1
-
16
(Celecoxib)
ubdmzqiusb(wwngjlehyc) = ftjinztslo etaofjiriq (meuxyhmzkj, 1357)
-
13 Dec 2023
(Naproxen)
ubdmzqiusb(wwngjlehyc) = ztpeheabmr etaofjiriq (meuxyhmzkj, 66.8)
Phase 4
26
jgxkmsplln(ydzpybdwem) = pbyjingijq ybgwtmodsv (dukhopqwgu, 2.4)
-
18 Oct 2023
Not Applicable
43
Continuous NSAIDs intake
xknxjmdtwy(znfkmxoixh) = toibnhesvx zkqrgvysps (rhvqjczdhz )
Positive
01 Jun 2022
Occasional NSAIDs intake
piecnuewhv(bmskzhcwus) = girtqzpqjn yizcamijqr (zyywoqqbfo )
Phase 4
24,081
araibvbxrc(fnulxrjqvz) = fbbqsphovy nfohijrvap (drapugicjb )
Positive
02 Mar 2022
araibvbxrc(fnulxrjqvz) = bljosaettd nfohijrvap (drapugicjb )
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Core Patent

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Approval

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Regulation

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