A 48 hour patch test performed in healthy volunteers to determine the presensitization (pre-existing allergy) of Neo-Synalar (neomycin sulfate 0.5%(0.35% neomycin base), fluocinolone acetonide 0.025%) Cream . Subjects also receive a positive control (Sodium Lauryl Sulfate) and a negative control (Saline).
The primary objective of this study is to determine if any subjects exhibit an allergic reaction which may be indicative of a pre-existing sensitization.

Start Date01 Jun 2014

Sponsor / Collaborator

Medimetriks Pharmaceuticals, Inc.

100 Clinical Results associated with Fluocinolone Acetonide/Neomycin Sulfate

100 Translational Medicine associated with Fluocinolone Acetonide/Neomycin Sulfate

100 Patents (Medical) associated with Fluocinolone Acetonide/Neomycin Sulfate

1,116

Literatures (Medical) associated with Fluocinolone Acetonide/Neomycin Sulfate

01 Jan 2025·Toxicology and Industrial Health

Effects of bisphenol A, bisphenol S, and tetramethyl bisphenol F on male fertility in Caenorhabditis elegans

Article

Author: Waligora, Katelyn D ; Clore, Jessica R ; Higley, Cole M ; Kuzmanov, Aleksandra ; Timmons, Shannon C

Research has shown that exposure to bisphenol A (BPA), a widely used plasticizer, can lead to meiotic errors, resulting in poor reproductive cell quality and infertility. Health-related concerns have prompted the search for BPA alternatives; however, evidence suggests that currently used BPA analogs, such as bisphenol S (BPS), may pose similar risks to human health. While the effects of BPA on female fertility are well documented, the impact of BPA exposure on sperm quality is poorly understood. To better understand the effects of bisphenol analogs on spermatogenesis, we synthesized a less investigated BPA analog, tetramethyl bisphenol F (TMBPF), and compared its reprotoxic potential to that of widely used BPA and BPS using C. elegans-based assays. We evaluated germ cell count, spermatid size, morphology, and activation in males treated with 0.5 mM ethanol-dissolved bisphenol analogs for 48 h as well as their cross-progeny number and viability. Our results indicated that all of the evaluated bisphenol analogs—BPA, BPS, and TMBPF—adversely affect male fertility to varying degrees. Whereas all three bisphenols reduced spermatid size, only BPA exposure resulted in impaired spermatid activation and significantly reduced brood size. In addition, a decrease in embryonic viability, suggestive of an increased incidence of sperm chromosomal aberrations, was observed following exposure to all of the tested bisphenols. Further investigation is necessary to fully elucidate the underlying mechanisms and implications of BPA, BPS, and TMBPF on spermatogenesis.

01 Jan 2025·Talanta

Cyano-functionalized porous hyper-crosslinked cationic polymers for efficient preconcentration and detection of phenolic endocrine disruptors in fresh water and fish

Article

Author: Zhao, Guijiao ; Wang, Chenhuan ; Wang, Qianqian ; Wang, Chun ; Wu, Qiuhua ; Wang, Zhi

Sensitively analyzing phenolic endocrine-disrupting chemicals (EDCs) in environmental substrates and aquatic organisms provides a significant challenge. Here, we developed a novel porous hyper-crosslinked ionic polymer bearing cyano groups (CN-HIP) as adsorbent for the highly efficient solid phase extraction (SPE) of phenolic EDCs in water and fish. The CN-HIP gave an excellent adsorption capability for targeted EDCs over a wide pH range, and the adsorption capacity was superior to that of several common commercial SPE adsorbents. The coexistence of electrostatic forces, hydrogen bond, and π-π interactions was confirmed as the main adsorption mechanism. A sensitive quantitative method was established by coupling CN-HIP based SPE method with high-performance liquid chromatography for the simultaneously determining trace bisphenol A, bisphenol F, bisphenol B and 4-tert-butylphenol in fresh water and fish. The method afforded lower detection limits (S/N = 3) (at 0.03-0.10 ng mL^-1 for water and 0.8-4.0 ng g^-1 for fish), high accuracy (the recovery of spiked sample at 88.0%-112 %) and high precision (the relative standard deviation < 8.5 %). This work provides a feasible method for detecting phenolic EDCs, and also opens a new perspective in developing functionalized cationic adsorbent.

01 Dec 2024·Environmental Pollution

Neurotoxic effects of perinatal exposure to Bisphenol F on offspring mice

Article

Author: Song, Miao ; Huo, Siming ; Du, Jiayu ; Zhang, Xuliang ; Li, Bo ; Li, Yanfei

Bisphenols constitute a diverse group of endocrine-disrupting chemicals (EDCs) that impact hormone activity. Bisphenol F (BPF) is commonly used as a substitute for Bisphenol A (BPA). The disruption of the immune system by EDCs during embryonic brain development has been suggested as a plausible factor to neurodevelopmental disorders. We investigated the neurotoxic effects of perinatal exposure to BPF on offspring mice. Female mice were exposed to BPF through their drinking water on day 0.5 of pregnancy, and this exposure continued until the offspring mice were weaned, throughout the perinatal period. Our findings revealed that exposure to BPF hindered both growth and neurodevelopment in offspring mice, with a more pronounced effect observed in males. Additionally, transcriptomic analysis was conducted on the brains of male offspring mice exposed to high doses of BPF. In summary, our study indicates that perinatal exposure to BPF results in neurodevelopmental impairments in male offspring mice, linked to oxidative stress, inflammatory responses, and immune dysregulation. These findings underscore that BPF may not be a safe substitute for BPA. Thus, there is a pressing need to reevaluate the current regulation of BPF.

100 Deals associated with Fluocinolone Acetonide/Neomycin Sulfate

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KEGG	Wiki	ATC	Drug Bank
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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Eczema	JP	Mitsubishi Tanabe Pharma Corp.	26 Aug 1963
Keratoderma, Palmoplantar	JP	Mitsubishi Tanabe Pharma Corp.	26 Aug 1963
Pruritus Ani	JP	Mitsubishi Tanabe Pharma Corp.	26 Aug 1963
Psoriasis	JP	Mitsubishi Tanabe Pharma Corp.	26 Aug 1963
Pyoderma	JP	Mitsubishi Tanabe Pharma Corp.	26 Aug 1963
Skin Diseases, Infectious	JP	Mitsubishi Tanabe Pharma Corp.	26 Aug 1963
Wound Infection	JP	Mitsubishi Tanabe Pharma Corp.	26 Aug 1963
Dermatophilosis	US	Medimetriks Pharmaceuticals, Inc.	11 Jun 1963

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02168478 (CTgov)	Phase 4	Anaphylaxis	206	Sodium Lauryl Sulfate Aqueous Solution (0.40%)+Neo-Synalar Cream+Saline	(sxkdaducqy) = nfkpcdibhf lzkjtdrgnp (ebnkquqilk, rsdcdgogth - qukfdyjsqg) View more	-	11 Dec 2015
FAME study (ARVO2014)	Phase 3	Diabetic macular oedema	-	Fluocinolone Acetonide 0.2 μg/d	(lqrfpbaqko) = azpxbpptgv pytwdcxtnb (ymewniavqi )	-	01 Apr 2014
FAME study (ARVO2014)	Phase 3	Diabetic macular oedema	-	fluocinolone acetonide (FAc) (Sham injection (control))	(lqrfpbaqko) = pqvhdcozmz pytwdcxtnb (ymewniavqi )	-	01 Apr 2014

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