Last update 20 Mar 2025

Copper Gluconate/Disulfiram

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DSF-Cu, Dicopp, Disulfiram/copper gluconate
+ [2]
Target
Action
inhibitors
Mechanism
ADHs inhibitors(Alcohol dehydrogenases inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC12H22CuO14
InChIKeyOCUCCJIRFHNWBP-IYEMJOQQSA-L
CAS Registry527-09-3
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 2
United States
15 Jun 2016
Breast CancerPhase 2--
GlioblastomaPhase 2--
Refractory Multiple MyelomaDiscovery
United States
21 May 2021
Metastatic Pancreatic CancerDiscovery
United States
17 Oct 2019
Recurrent GlioblastomaDiscovery
United States
09 Mar 2017
Liver CancerDiscovery
United States
01 Jul 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
(Nab-Paclitaxel/Gemcitabine + DSF/Cu)
rzcwjnhtzr(bweyucrlyk) = scchuazfjw pgtvbieuhi (kvlusedxaw, gmdvbghhtl - nknqmrgfjj)
-
18 Oct 2023
rzcwjnhtzr(bweyucrlyk) = ophuhonkyf pgtvbieuhi (kvlusedxaw, bhzmzjmgif - rexhjkqznt)
Phase 2
23
Temozolomide (TMZ)+Disulfiram/Copper
(iiznxciuyi) = hctgervcsr vetchtfltp (pltkbaxyyt, zvkyulqceo - tvggubfsvf)
-
13 Sep 2021
Not Applicable
Recurrent Medulloblastoma
ALDH | Nestin- | CD133-positive
-
dikgtbpskq(vobxoovwhv) = DSF/Cu++ induced cell death (increased AnnV/PI, cleaved-Poly(ADP-ribose)polymerase fraction, and Apoptosis Inducing Factor on WB/FC/IF, in vitro and ex vivo) through NPL4 accumulation in cell nucleus and intracellular buildup of poly-ubiquitylated proteins tdmhngnazb (krljkfknxv )
Positive
09 Nov 2020
Copper
Not Applicable
24
qecawvqthj(eefswtmhzw) = yjulmxyjqa wucunmgpwu (zxaeomsyet )
Positive
11 Nov 2019
(Control (No treatment))
qecawvqthj(eefswtmhzw) = eqovubjhaf wucunmgpwu (zxaeomsyet )
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Approval

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Regulation

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