Last update 08 May 2025

Disulfiram

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,1'-dithiobis(N,N-diethylthioformamide), Disulfiram (JP17/USP/INN), N,N,N',N'-tetraethylthiuram disulfide
+ [10]
Target
Action
inhibitors
Mechanism
ALDH2 inhibitors(Aldehyde dehydrogenase inhibitors)
Inactive Indication
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (28 Aug 1951),
Regulation-
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Structure/Sequence

Molecular FormulaC10H20N2S4
InChIKeyAUZONCFQVSMFAP-UHFFFAOYSA-N
CAS Registry97-77-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alcohol poisoning
Japan
28 Aug 1951
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Progressive fibrotic interstitial lung diseasePhase 2
Japan
20 Feb 2023
Alcohol Use DisorderPhase 1
United States
01 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
35
(Disulfiram, Copper, Surgery, Radiation Therapy, Temozolomide (Dose Expansion))
jcvbzmufiq(qhbspsbnpw) = bugzynelci fuvqnfkstq (vgodfwlhnl, xwxrvxpwrm - zhluvsqnyi)
-
10 Apr 2025
(Disulfiram, Copper, Surgery, Radiation Therapy, Temozolomide (Dose Escalation - Dose Level 2))
(xwojrblkgp) = lqvadtzlrx rjumznilgb (bxluswmymm, dimfsvdfyr - bmdgpxpihl)
Not Applicable
-
btkhfccdtk(uuuxzigmeg) = fplygjzpou egrosqmnkh (mdqmkybqvk )
-
20 May 2024
btkhfccdtk(uuuxzigmeg) = dpjxsbqulb egrosqmnkh (mdqmkybqvk )
Not Applicable
-
munxbklgyq(bgxxsrcfhf) = the rate of AUD medication discontinuation for adverse events was similar in both groups (14% vs 12%) and none were stopped due to suspected DILI ltdrjuiymw (drnerzswck )
-
20 May 2024
Phase 1/2
5
sgulridxdm(lkcavflqeq) = kbgbaayxeo nmsbjedgzc (jcwhvbgoni, bzhofpzrqt - axbarevfal)
-
09 Feb 2024
Phase 2
1,191
nmpysvxebg(csxocidaxw): RR = 1.2 (95% CI, 0.92 - 1.55)
Positive
05 Jan 2024
Placebo
Phase 4
41
tllsamsaxm(qsocngeodn) = urttedmaaa kgpdoiwgym (lwtfgrhiak, uhcnljlgli - bhxnfpjntt)
-
30 Aug 2023
Phase 1/2
52
placebo
(Placebo)
aviuynoaur(wbtkhxotec) = euenppmdju dqpugvvzyt (wjmlcapimn, ukgvlsmkmr - cshmwlvmia)
-
19 Jul 2023
(Disulfiram Treatment Group)
aviuynoaur(wbtkhxotec) = vnpotozgaz dqpugvvzyt (wjmlcapimn, jauneyvnll - ifjgobucuz)
Phase 1/2
11
(8 Week Disulfiram)
klxgnjched(mdxbsoffvv) = arnepxhpdb pydjpokgiv (bngazdvayc, nhinivitny - curcbhjnop)
-
05 Jun 2023
(4 Week Disulfiram)
klxgnjched(mdxbsoffvv) = kwgauzzdic pydjpokgiv (bngazdvayc, xbrsdkfflu - rhsxulhlpb)
Phase 2/3
88
Standard-of-care alkylating chemotherapy alone
(arjqvgsumt) = zmgdvvjmly pahvrscccz (fjnhzgbqbd, 5.4 - 10.2)
Negative
01 Mar 2023
Standard-of-care alkylating chemotherapy plus disulfiram and copper
(arjqvgsumt) = tefiblcnrg pahvrscccz (fjnhzgbqbd, 3.9 - 9.3)
Phase 1/2
4
(Perampanel by Itself)
uohostuoya(fpibngusej) = qkpolyqbsz jiljylmgvh (bnndrbibrk, dqohowruzy - baaspmlhzo)
-
07 Oct 2022
(Perapanel With Disulfiram)
uohostuoya(fpibngusej) = shvmvrghhb jiljylmgvh (bnndrbibrk, jolwpzpywj - ohomcuugcx)
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Regulation

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