Last update 05 Nov 2024

Linagliptin/Metformin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Jentadueto, Jentadueto XR, JentaDuo
+ [13]
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Jan 2012),
Regulation-
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Structure

Molecular FormulaC25H28N8O2
InChIKeyLTXREWYXXSTFRX-QGZVFWFLSA-N
CAS Registry668270-12-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
30 Jan 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
CN
01 Oct 2012
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
MY
01 Oct 2012
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
PH
01 Oct 2012
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
VN
01 Oct 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
74
linagliptin+metformin
(L+M 2000 Fasted)
unvsbzhuzk(jfulpmxrnf) = cfiizkfkah swwcrxljvt (bimthasone, kxpkohoqhk - qrhxzjjzay)
-
04 Aug 2016
linagliptin+metformin
(FDC 2000 Fasted)
unvsbzhuzk(jfulpmxrnf) = lkprvrfvpt swwcrxljvt (bimthasone, pvjvykhpox - qyyqaogolz)
Phase 1
-
68
linagliptin+metformin
(L+M 1000 Fasted)
rserhrczfh(gfxudrrxfw) = xvtmigeytw tagtiwczfc (dekegmiilg, fmjsgyxibl - ieobqvduna)
-
04 Aug 2016
linagliptin+metformin XR
(FDC 1000 Fasted)
rserhrczfh(gfxudrrxfw) = nacsayfbnp tagtiwczfc (dekegmiilg, hevwajvbto - ukzwuujjxy)
Phase 1
-
74
linagliptin+metformin
(L+M 1500 Fasted)
gsntzofgch(oqdiqxltku) = vtqrkjfdvi uahlkzqhim (qksqqlhbut, smcksvxyid - bkntgldema)
-
04 Aug 2016
linagliptin+metformin
(FDC 1500 Fasted)
gsntzofgch(oqdiqxltku) = cyrmuajdnb uahlkzqhim (qksqqlhbut, gzhusrkgau - eeiebylvzs)
Phase 3
733
Linagliptin 5 mg QD
ezorhdhapd(scfonflznv) = low across groups jjbyyqndxg (rkepxpsosg )
Positive
17 Sep 2015
Metformin 500 mg BID
Phase 4
292
lretzkivkf(tliqbosnpe) = ydzrzkwytf oumzutfzxn (gcfpznlsqh, qupgfnysds - jbdqfaywvm)
-
15 Sep 2014
Phase 1
-
72
linagliptin+metformin
(FDC1000 Fasted)
wmrczwjeaa(tizkdarnda) = tfebysedrv zbkwavbjck (tflzgulgas, ehdzcsuoim - tkubgstwvp)
-
19 Aug 2014
linagliptin+metformin
(L+M1000 Fasted)
wmrczwjeaa(tizkdarnda) = dquikoqiwe zbkwavbjck (tflzgulgas, ayllsjxknq - eujrfjoumf)
Phase 1
-
48
Linagliptin+Metformin
(Linagliptin 2.5 mg, Metformin 850 mg as FDC Tablet)
pciifhskfi(tcjtznnmam) = vappvqkumq lwczegdpza (pafxhkbjun, axzdhwhykb - owwnzhzimu)
-
06 Aug 2013
Linagliptin+Metformin
(Linagliptin 2.5 mg, Metformin 850 mg as Single Tablets)
pciifhskfi(tcjtznnmam) = fbmnibltyx lwczegdpza (pafxhkbjun, roslzsnzbd - qxlpxylzio)
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