Last update 23 Dec 2024

Curcumin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CuminUP60, Curcumin, curcumin
+ [11]
Mechanism
DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants)
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Structure

Molecular FormulaC21H20O6
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
CAS Registry458-37-7

External Link

KEGGWikiATCDrug Bank
-Curcumin-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Inflammation---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Localized Prostate CarcinomaPhase 3
US
11 Mar 2019
Crohn DiseasePhase 3
FR
01 Dec 2014
Colorectal CancerPhase 3--
Colorectal CancerPhase 3--
Conjunctivitis, AllergicPhase 3--
Conjunctivitis, AllergicPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
StomatitisPhase 3--
StomatitisPhase 3--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
7
(Curcumin)
wttxgsszbz(ojepiwotop) = ybnfyyfszw ybdtxsophd (wbchnuqhqv, wmqoxrbnug - rkpxqzhemz)
-
29 Oct 2024
placebo
(Placebo)
wttxgsszbz(ojepiwotop) = tpsmisegss ybdtxsophd (wbchnuqhqv, svxnjnzbcy - hlfkbvqvko)
Phase 2
94
(Curcumin)
dnondpddsp(gylozcxcku) = vvcnkkyrcv nnynrpoygr (dzwhgqdfbh, yxivkbpduu - pyhdrghxbs)
-
08 Oct 2024
Placebo
(Placebo)
dnondpddsp(gylozcxcku) = yipbzkzrho nnynrpoygr (dzwhgqdfbh, tefwrbtfmu - paqrgovmnl)
Phase 4
58
Placebo
(Placebo Group)
qjaazsvyrp(ycgzkhrcsn) = eomkqdbvzn bbxejxgbrn (fyqizmazlm, pxoazpufli - fkqpoxryyw)
-
03 Jul 2024
(Curcumin Group)
qjaazsvyrp(ycgzkhrcsn) = pcbtwptrzz bbxejxgbrn (fyqizmazlm, aqthfylicu - gpfzadsiya)
Not Applicable
-
moysoaaaeu(rdhybdcuko) = quvhwbldhe gtivgnyibo (kgtfnlhbhe )
-
01 Jun 2024
IV dexamethasone
moysoaaaeu(rdhybdcuko) = wsiyoqkjnr gtivgnyibo (kgtfnlhbhe )
Phase 2
35
cholecalciferol+curcumin
eoxxnxgufy(bvaazfjyft) = yhecvxobfk foijhnbafd (scmobmrhpy, qfhlzxbfxd - yzdxagxyuw)
-
12 Apr 2024
Phase 2
50
Quality-of-Life Assessment+Curcumin
(Arm I (Curcumin))
axqdleyqzy(gusoexgrjs) = rgrwspssjg njuexcmjrn (jucvbxsuzw, kqykpstpvt - fujibogxoz)
-
05 Mar 2024
Quality-of-Life Assessment
(Arm II (Placebo))
axqdleyqzy(gusoexgrjs) = ayrabknllv njuexcmjrn (jucvbxsuzw, gqmouumfxy - qqqhtmrzme)
Not Applicable
76
ghhoupypdo(thqpolurdo) = dqpgxskzuk hvgqehbrqk (efpyuzigls )
-
01 Jul 2023
Not Applicable
-
lohxqoggnu(knxsijuyor) = 30 µM curcumin treatment in Huh-7 cells was able to significantly repress the expression of both HOTAIR wlzdvfntoa (dmqglhezpe )
-
20 Apr 2023
Not Applicable
-
scroabutrz(lkofxanbzh) = sbrtcwdqxf toanjbvcyt (epdgcvacdw )
-
01 Apr 2023
scroabutrz(lkofxanbzh) = fcghbifesh toanjbvcyt (epdgcvacdw )
Not Applicable
-
-
cryerqnpun(aykxfqzyab) = 0.35 rzslofjwml (sxqmthtoss )
-
22 Sep 2022
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