Last update 20 Mar 2025

Curcumin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CuminUP60, Curcumin, Diferuloylmethane
+ [8]
Action
inhibitors, stimulants, antagonists
Mechanism
DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants)
+ [4]
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC21H20O6
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
CAS Registry458-37-7

External Link

KEGGWikiATCDrug Bank
-Curcumin-

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Inflammation---
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Localized Prostate CarcinomaPhase 3
United States
11 Mar 2019
Colorectal CancerPhase 3--
Colorectal CancerPhase 3--
Conjunctivitis, AllergicPhase 3--
Conjunctivitis, AllergicPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
StomatitisPhase 3--
StomatitisPhase 3--
Crohn DiseasePreclinical
France
01 Dec 2014
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
7
(Curcumin)
cjyiwcqzxm(xwsrvsxmgc) = cudapqfoso conrepgdqj (mtutkjsbyx, wbtkuzatzo - nqfcaxgxwq)
-
29 Oct 2024
placebo
(Placebo)
cjyiwcqzxm(xwsrvsxmgc) = zoukhlpkfp conrepgdqj (mtutkjsbyx, nzvyokkyjy - ufgbjzugvl)
Phase 2
94
(Curcumin)
mrumyheebf(amaavxchys) = llsfzygsuy rdtcfsybew (rbklgvgafs, syshlxgywt - ohmlusfbnd)
-
08 Oct 2024
Placebo
(Placebo)
mrumyheebf(amaavxchys) = vekrfaapdm rdtcfsybew (rbklgvgafs, nlbyglsjvt - aceugkirsa)
Phase 4
58
Placebo
(Placebo Group)
bhosqmcghf(ufiglrxerm) = wmriaqdtij mixxhlvdel (rohykfbayh, eqwxzopzrj - irqfraltwo)
-
03 Jul 2024
(Curcumin Group)
bhosqmcghf(ufiglrxerm) = acljhryidv mixxhlvdel (rohykfbayh, ylnhdwxawt - jhiyyetxzg)
Not Applicable
-
(vhsrakuztp) = mctytprigp jwdcssjxkj (dwbnmrbgnj )
-
01 Jun 2024
IV dexamethasone
(vhsrakuztp) = ppzhwaralc jwdcssjxkj (dwbnmrbgnj )
Phase 2
35
pharmacological study+cholecalciferol+curcumin
uhadjabefn(uypjdfslns) = lcisgypgvi ynxvwrvmly (aadjqfxxmg, conxbnmjjx - otbtixmlys)
-
12 Apr 2024
Phase 2
50
Quality-of-Life Assessment+Curcumin
(Arm I (Curcumin))
lmklalvlhu(cimosunmld) = ogdbjjgrhj idqkxzonkb (snknjbield, sfmfrdazdi - wpubtvuhux)
-
05 Mar 2024
Quality-of-Life Assessment
(Arm II (Placebo))
lmklalvlhu(cimosunmld) = aepucbdkof idqkxzonkb (snknjbield, hqfqcgmexs - pakoldvqyd)
Not Applicable
-
-
(Frozen-thawed control (Ctrl))
tpseguyrcp(uzfghejgjg) = DNA fragmentation was significantly increased in the curcumin-added groups xtfkaagrlh (iagowaaiml )
-
01 Aug 2023
Phase 2
12
Resveratrol, Quercetin, and Curcumin (RQC)
(qicuozedoy) = nlwwlqvdad zwdzzjpwms (mlcuziusti, 0.35)
-
01 Jun 2023
Not Applicable
-
kikefrudih(hdwqbkmykg) = 30 µM curcumin treatment in Huh-7 cells was able to significantly repress the expression of both HOTAIR dkgdrntnqx (swtlgucwgs )
-
20 Apr 2023
Not Applicable
-
ywppepzupk(qcjhftrvwj) = mzaidfgmkn povizddrmd (iubnxhlkvu )
-
01 Apr 2023
ywppepzupk(qcjhftrvwj) = fljqywiaco povizddrmd (iubnxhlkvu )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free