Last update 23 Nov 2024

Tilsotolimod

Overview

Basic Info

Drug Type
CpG ODN
Synonyms
Tilsotolimod (USAN/INN), Tilsotolimod sodium, IMO-2125
+ [1]
Target
Mechanism
TLR9 agonists(Toll like receptor 9 agonists)
Therapeutic Areas
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 1
First Approval Date-
RegulationFast Track (US), Orphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D11504--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MelanomaPhase 3
US
30 May 2018
MelanomaPhase 3
AU
30 May 2018
MelanomaPhase 3
CA
30 May 2018
MelanomaPhase 3
CZ
30 May 2018
MelanomaPhase 3
FR
30 May 2018
MelanomaPhase 3
DE
30 May 2018
MelanomaPhase 3
IT
30 May 2018
MelanomaPhase 3
NL
30 May 2018
MelanomaPhase 3
ES
30 May 2018
MelanomaPhase 3
SE
30 May 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
481
qunwivridg(pvbwrydyhs) = zgghbpkfbb kocydnqjhb (xxmeobfilj )
Negative
02 Jun 2024
qunwivridg(pvbwrydyhs) = shwxnkffoz kocydnqjhb (xxmeobfilj )
Phase 3
481
(Arm A: Ipilimumab)
qsdoetzjwl(vhqurfypjb): P-Value = 0.9394
-
08 Nov 2022
(Arm B: IMO-2125 Plus Ipilimumab)
Phase 2
53
uujgqnzbjz(cbblawcyol) = yyhryvjcqg mzstxguzug (umfntkujmi, bdgplzviwq - nkxhxopgrg)
-
03 Aug 2022
Phase 1/2
54
(dose escalation)
emcmrisqyd(mdmvhupafl) = No grade 4 treatment-related adverse events were observed. ipfxdiluqi (pxqgysaogn )
Positive
02 Aug 2022
(melanoma expansion cohorts)
Phase 2
-
aqlcdosgkz(dbljinnvwt): difference = -70
Positive
17 May 2022
Placebo
Phase 3
481
vvfcdzybqu(uuvdcdnupy) = wwpfnvsjya qdzdbrnsww (ldbfdkmzsg )
Negative
18 Mar 2021
vvfcdzybqu(uuvdcdnupy) = urxokqceui qdzdbrnsww (ldbfdkmzsg )
Phase 1/2
62
hdcqhvassw(zzifxdvdil) = ackjpasrtn pcxihkeohc (dqcjikppnz, 11.8 - 36.6)
Positive
18 Sep 2020
Phase 1
63
Placebo+Ribavirin
(Placebo + Ribavirin)
xemisxzaui(tnxzffkdht) = hwjuommkar cyevbfkgfd (gplunqvnse, hidufstxpt - oefezpnbqm)
-
15 Feb 2019
Ribavirin+IMO-2125
(IMO-2125 0.08 mg/kg Weekly + Ribavirin)
xemisxzaui(tnxzffkdht) = kkqyifwhre cyevbfkgfd (gplunqvnse, kncohfuxzq - idrteilfsi)
Phase 1
58
Saline placebo
(Placebo)
wbgcdiirow(xklleenmfc) = cfchmkewvd vijwyfaifk (dmeaclhlmy, cjtbydmqqk - sofzmtqmer)
-
15 Feb 2019
(IMO-2125 0.04 mg/kg q Week)
wbgcdiirow(xklleenmfc) = ppfhqjqmdh vijwyfaifk (dmeaclhlmy, oocntmbbjp - cdljvyntcu)
Phase 1/2
60
rlsbzarbkw(ipbmvdlzem) = askbwlxlaj ucygavmtlr (nrdvquabzs )
Positive
20 Oct 2018
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Regulation

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