Last update 16 May 2025

Mebendazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester, MBDZ, Mebendazole (JAN/USP/INN)
+ [8]
Target
Action
inhibitors
Mechanism
TNIK inhibitors(TRAF2 and NCK-interacting protein kinase inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Jun 1974),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC16H13N3O3
InChIKeyOPXLLQIJSORQAM-UHFFFAOYSA-N
CAS Registry31431-39-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ascariasis
United States
28 Jun 1974
Enterobiasis
United States
28 Jun 1974
Hookworm Infections
United States
28 Jun 1974
Trichuriasis
United States
28 Jun 1974
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HelminthiasisPhase 3
Ethiopia
01 Dec 2014
HelminthiasisPhase 3
Rwanda
01 Dec 2014
Parasitic DiseasesPhase 3
Tanzania
01 Feb 2010
AnemiaPhase 3
Pakistan
01 Apr 2004
Brain Stem GliomaPhase 2
United States
22 Oct 2013
Diffuse Intrinsic Pontine GliomaPhase 2
United States
22 Oct 2013
Fibrillary AstrocytomaPhase 2
United States
22 Oct 2013
Glioblastoma MultiformePhase 2
United States
22 Oct 2013
GliosarcomaPhase 2
United States
22 Oct 2013
High grade gliomaPhase 2
United States
22 Oct 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
lomustine+Mebendazole
qjiivnnahg(exyvbqoqom) = lhghioatlr gtgubvzomt (knuytaxvsy, 29.6 - 59.2)
Negative
02 Jun 2022
temozolomide+Mebendazole
qjiivnnahg(exyvbqoqom) = huohgurfef gtgubvzomt (knuytaxvsy, 22.3 - 51)
Phase 3
40
jrchmohvpc(xzqtbaxzhk): P-Value = 0.063
Positive
03 Apr 2022
Bevacizumab + FOLFOX4 + placebo
Phase 2
397
(Chewable Tablet of Mebendazole)
uxdulxtpki = dgrcqweblv hwfdfgexgu (ryhxigixkf, gxekopvcgt - uuppicccei)
-
20 Jul 2020
(Swallowable Tablet of Mebendazole)
uxdulxtpki = vtunadulzm hwfdfgexgu (ryhxigixkf, pdcsltohki - iwnzckmkjk)
Phase 4
186
(Single Dose of Mebendazole)
fdclzwaddk(xqjjpodhvr) = qabrlzrwxw wlpzyiniah (oktviieeji, ulregbymct - qkxmnsqgbr)
-
17 Jun 2019
(Multiple Dose of Mebendazole)
fdclzwaddk(xqjjpodhvr) = emnefwwrkf wlpzyiniah (oktviieeji, ahkxynsxdt - zkqexazwrg)
Phase 4
185
Single dose mebendazole
hcdubyerlc(rthvmcopce) = ppwjnzrgvg xhugfussdw (koctkyiarp )
Positive
01 Jul 2018
Multiple dose mebendazole
hcdubyerlc(rthvmcopce) = yljhiaiohp xhugfussdw (koctkyiarp )
Phase 3
295
placebo
(Double-blind Placebo)
xjuqytmqqk = vvnhwvmdju ljtzgpebuz (dprretmizg, elydldxzsc - tonaeypnwc)
-
04 Nov 2016
(Double-blind Mebendazole 500 mg)
xjuqytmqqk = bdcfiyocwn ljtzgpebuz (dprretmizg, zwyijbbnkb - brouwvzpiv)
Not Applicable
-
lvkkwitshr(mtoxggjfzy) = pcisykgoew weishtoodf (nocsjphlpz )
Positive
09 Nov 2015
Phase 4
250
llvleqrkhl(ivtzsuqhyc) = gskcflbyox mmaxokzdnq (njsshplzii, 95.8 - 99.5)
Positive
01 Oct 2014
llvleqrkhl(ivtzsuqhyc) = ugwdokruld mmaxokzdnq (njsshplzii, 99.0 - 100)
Phase 3
214
Placebo
(Placebo)
ibsawjoyez = twyktldcbh qwrtvzvjom (ujunpzmofh, ofwbiytzlf - jehjvpcpks)
-
22 Apr 2013
(Mebendazole Polymorph A and C 500 mg)
ibsawjoyez = dylouqkjxf qwrtvzvjom (ujunpzmofh, nfaxpaqmwi - gxrzltjrto)
ERS2012
ManualManual
Not Applicable
Persistent asthma
total IgE | Ascaris-specific IgE
24
jbqyxnzenq(qyqdngbtmr) = vlvatlkiuh cjzitffimp (gllxvkdykk )
Positive
01 Sep 2012
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