Last update 20 Mar 2025

Seclidemstat mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Seclidemstat
+ [2]
Target
Action
inhibitors
Mechanism
KDM1A inhibitors(Lysine-specific histone demethylase 1 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationRare Pediatric Disease (United States), Fast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H23ClN4O4S
InChIKeyMVSQDUZRRVBYLA-HYARGMPZSA-N
CAS Registry1423715-37-0
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Clear Cell SarcomaPhase 2
United States
15 Jan 2022
Desmoplastic Small Round Cell TumorPhase 2
United States
15 Jan 2022
FibrosarcomaPhase 2
United States
15 Jan 2022
Histiocytoma, Angiomatoid FibrousPhase 2
United States
15 Jan 2022
MyoepitheliomaPhase 2
United States
15 Jan 2022
Myxoid LiposarcomaPhase 2
United States
15 Jan 2022
Chronic Myelomonocytic LeukemiaPhase 2
United States
07 Jul 2021
Recurrent Myelodysplastic SyndromePhase 2
United States
07 Jul 2021
Ewing SarcomaPhase 2--
Solid tumorDiscovery
United States
29 Apr 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
16
(yfrgdfxhdc) = fenjxoyetz tssjametps (tfyaajlncl )
Positive
17 Jun 2024
Phase 1/2
14
(yskvjfokcy) = cwakbdzfhl nxurwjqncp (cszocvdsxk )
Positive
14 May 2024
Phase 3
Sarcoma | Ewing Sarcoma
FET-Rearranged
13
(gziendmpnd) = dtowxobqln jniqfffixb (xubutuvdcx )
Positive
01 Dec 2022
(first-relapse Ewing sarcoma patients)
(gziendmpnd) = crjsqayzcv jniqfffixb (xubutuvdcx )
Phase 1/2
6
(ddqdwwdhbq) = vwzxvijfte kxnozcfkon (uffpcxlhem )
Positive
15 Nov 2022
Phase 1
27
(myunbnrwzs) = 1 pt elevated lipase ddkiahrtgy (whngjlirmj )
Positive
28 May 2021
Phase 1
-
(gocjwygdli) = apfxthacxg hjraexiyvt (xvarrcuzde )
Positive
28 May 2021
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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