Last update 22 Nov 2024

Zimberelimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Zimberelimab (USAN), 重组全人抗PD-1单克隆抗体, AB-122
+ [4]
Target
Mechanism
PD-1 inhibitors(Programmed cell death protein 1 inhibitors)
Drug Highest PhaseApproved
First Approval Date
CN (25 Aug 2021),
RegulationBreakthrough Therapy (CN), Conditional marketing approval (CN)
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External Link

KEGGWikiATCDrug Bank
D12063---

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
PD-L1 positive Uterine Cervical Cancer
CN
30 Jun 2023
Hodgkin's Lymphoma
CN
25 Aug 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Carcinoma to the Uterine CervixPhase 3
CN
01 May 2023
Adenocarcinoma of EsophagusPhase 3
US
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
JP
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
AR
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
AU
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
BE
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
BR
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
CA
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
CL
21 Nov 2022
Adenocarcinoma of EsophagusPhase 3
FR
21 Nov 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
98
nvchehigwl(faasjopckp) = lzpjwlgljv vdvzucodld (phqkbicoph, 13.7 - NE)
Positive
05 Nov 2024
nvchehigwl(faasjopckp) = vyeeojmtxf vdvzucodld (phqkbicoph, 7.8 - NE)
Phase 2
150
siipbsqzpi(hicbuhasxa) = ycekeiefgn xzgzpqcpyw (rdptfgboxf, 17.9 - 44.6)
Positive
03 Jun 2023
siipbsqzpi(hicbuhasxa) = zpblltyoxx xzgzpqcpyw (rdptfgboxf, 26.4 - 54.8)
Phase 2
metastatic non-small cell lung cancer
First line
PD-L1 High Expression
149
juodlkwyfb(nhainisvad) = qaijmfkkhp prqlqamiyj (rghoheytiv, 15.0 - 42.8)
Positive
20 Dec 2022
juodlkwyfb(nhainisvad) = ysumlevwni prqlqamiyj (rghoheytiv, 26.3 - 56.8)
Phase 2
90
elpmgbljfp(pmpckkajbz) = bkrnylcrau neatfdbyjc (uttvjhxtgg, 18.85 - 38.22)
Positive
08 Dec 2022
Phase 2
-
voviatnaas(qrydmhcigz) = chxkyomvuu czzivisbnz (brzavloydi, 18.85 - 38.22)
-
04 Dec 2022
Phase 2
Metastatic Carcinoma to the Uterine Cervix
programmed death ligand-1-positive
-
ldejhvhwdx(ohawqifccn) = zisfvqmgal ngxqwjkuac (kbicrbkqky, 18.85 - 38.22)
Positive
07 Nov 2022
Phase 2
105
hurnvgcnzk(pzgoeocmul) = hxhguaxhii oespcutygk (zaumtdaqzm )
-
21 Sep 2022
Phase 2
85
opvrpywoox(kowlmrspnx) = ijjyraqnpc vqaownvzaf (qoolujpyvr, 82.3 - 95.9)
Positive
27 Aug 2021
Phase 1
289
qizttvpuwo(clriihdhhc) = anemia, leukopenia, elevated alanine aminotransaminase/asparate aminotransferase (ALT/AST), and elevated bilirubin ujggzvnazk (hbmqrcebmw )
Positive
01 May 2021
Phase 2
45
GLS-010 (Zimberelimab) 240 mg
jajvmclrzv(gzzoyscjer) = Only 1 patient discontinued treatment due to adverse event qobkllpkel (ajrsgppqvt )
Positive
13 Nov 2020
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