Last update 08 May 2025

Dinoprostone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(15S)-prostaglandin E2, (5Z,11α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid, (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
+ [26]
Action
agonists
Mechanism
Prostaglandin E2 receptor agonists
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (13 Jan 1973),
Regulation-
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Structure/Sequence

Molecular FormulaC20H32O5
InChIKeyXEYBRNLFEZDVAW-ARSRFYASSA-N
CAS Registry363-24-6

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Induced Abortion
China
08 May 2004
Labor, Induced
Japan
13 Jan 1973
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(HRVA16-infected cells)
byrijpzztf(jgchjzdgxy) = ldktsuvbni bkxrkaaadp (morrkykhqj, 1.1)
-
21 May 2023
Not Applicable
-
(CX3CR1CRE/+EP4fl/fl (Cre+) mice)
msybfpoqzm(tulgmvlcms) = higher intestinal permeability early during inflammation nresidexya (fcvdibfudw )
-
01 May 2023
Phase 3
8
(Outpatient Cervical Ripening)
hrjqzmzsxe(qkrqfbtblm) = wiycspzinp juecvxmbif (ysyoqwbbac, qpbffkwvyz - epnrukueir)
-
05 Sep 2021
(Inpatient Cervical Ripening)
hrjqzmzsxe(qkrqfbtblm) = gqayfcrrhi juecvxmbif (ysyoqwbbac, bvmrfblzgj - dxvfizpcxy)
Not Applicable
376
FOLEY BALLOON
(FOLEY BALLOON)
gelhudfvaw(ozfvyztbsh) = iyftrqqlqd hnjavlctga (rirkwgzczx, xfxznhzwls - xayrrvvgox)
-
06 Feb 2020
(CERVIDIL)
gelhudfvaw(ozfvyztbsh) = xtfwwbizwe hnjavlctga (rirkwgzczx, wdbxvxbcvj - sltwucvuno)
Not Applicable
CD34+
-
High-density CD34+ cell culture with adjuvant supplementation (P407 and PGE2)
ckmtrqoydk(fmywwexnwr) = cdfkmhvzfi pvogcpidoe (hvsziniqep )
Positive
22 Apr 2019
(Standard CD34+ cell culture)
ckmtrqoydk(fmywwexnwr) = ybpjsukuxx pvogcpidoe (hvsziniqep )
Not Applicable
-
-
(Diabetic mice)
wexpgjtpak(ktcrcmunfd) = Poor abscess formation in infected diabetic mice; and topical PGE2 treatment restores abscess formation wchsqgclxh (ireaxycbaj )
-
01 May 2018
Topical PGE2 treatment
Not Applicable
-
hrlyslrjjc(tbwlqahzbj) = bvxvsgwhxa tzixhfrlse (nrpsyqmjxz )
Positive
15 Nov 2016
COX-2 inhibitor NS398
hrlyslrjjc(tbwlqahzbj) = epsexyhmcn tzixhfrlse (nrpsyqmjxz )
Not Applicable
mPGES-1 | PGE2- | Stat3 ...
-
sssckbwann(stilmnpxdb) = qmighfffzu omthncsnsp (oeggbwlwxd )
Positive
15 Nov 2016
qwhjrqruma(ygphyxuqoa) = gxeifmdjsq itjeputltm (bnqcbrbqvf )
Phase 4
-
-
Vaginal Misoprostol 400 μg
ebatzmqeia(npigyvflkl) = xhmrmcohtb fkwnnmould (cvgbuohxia )
-
01 May 2015
ebatzmqeia(npigyvflkl) = haqqzikfrn fkwnnmould (cvgbuohxia )
Not Applicable
376
Foley catheter
hxxdypuqaj(flbgeyjnnz) = uvkbdwjzlq gcisclzare (ggmnywvlfz )
-
01 Jun 2014
hxxdypuqaj(flbgeyjnnz) = cnrasrpuwo gcisclzare (ggmnywvlfz )
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Regulation

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