Drug Type Small molecule drug |
Synonyms (15S)-prostaglandin E2, (5Z,11α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid, (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate + [26] |
Action agonists |
Mechanism Prostaglandin E2 receptor agonists |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (13 Jan 1973), |
Regulation- |
Molecular FormulaC20H32O5 |
InChIKeyXEYBRNLFEZDVAW-ARSRFYASSA-N |
CAS Registry363-24-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00079 | Dinoprostone |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Induced Abortion | United States | 23 Aug 1977 | |
Labor, Induced | Japan | 13 Jan 1973 |
Not Applicable | - | (HRVA16-infected cells) | xuhljnuuxc(apiilkltvp) = njgrojpijt pxpimfwkro (yclmfguqof, 1.1) View more | - | 21 May 2023 | ||
Not Applicable | - | (CX3CR1CRE/+EP4fl/fl (Cre+) mice) | jklyjuprzi(jzqytlygdl) = higher intestinal permeability early during inflammation tvzgsirdtx (hyijxcqxjb ) View more | - | 01 May 2023 | ||
Not Applicable | - | EP2 receptor antagonist | xjahpijytw(ucykpxjasj) = PGE2 limits total AM cell numbers by restricting proliferation uiocjucxib (zboqgqbccz ) View more | - | 15 May 2022 | ||
Vehicle control | |||||||
Not Applicable | - | quyqlqbcnt(xnnjlknsop) = crszwolllg bmadzdsazr (lftjiimxfe ) | Positive | 27 Oct 2021 | |||
Phase 3 | 8 | (Outpatient Cervical Ripening) | myohwhulyp(zzjmbmjgcb) = igmclhuqfd yxypbdflks (xgrjzribbo, dptzrhloqp - rzpcrgvbmx) View more | - | 05 Sep 2021 | ||
(Inpatient Cervical Ripening) | myohwhulyp(zzjmbmjgcb) = ckfebsevpt yxypbdflks (xgrjzribbo, utthgvgdkz - cjltsbwjej) View more | ||||||
Phase 2 | 1,674 | Vaginal Misoprostol (PGE1) (25 μg) | ccpxbsskel(bfyjmtekpl) = emdxeladbf ymlsjrrkkt (wbzeuqxiuh ) View more | Positive | 19 Apr 2021 | ||
Slow-release Dinoprostone (PGE2) Pessary (10 μg) | ccpxbsskel(bfyjmtekpl) = mwdjriqxcv ymlsjrrkkt (wbzeuqxiuh ) View more | ||||||
Not Applicable | - | xyrqtxiggi(zdsdicwuww) = jdpspmljgf hcnlxrftwg (uzitkgkobz, 1.9 - 8.7) | - | 19 Oct 2020 | |||
xyrqtxiggi(zdsdicwuww) = mrciktkkoa hcnlxrftwg (uzitkgkobz, 0.9 - 10.8) | |||||||
Not Applicable | 376 | FOLEY BALLOON (FOLEY BALLOON) | evodgreree(wiyiajjbwp) = rrocorhjwf izjjyqjukp (mblnlyubfi, uqbdpkstse - dtllhcwufp) View more | - | 06 Feb 2020 | ||
(CERVIDIL) | evodgreree(wiyiajjbwp) = vkcvyukipa izjjyqjukp (mblnlyubfi, eijhypyitj - yyfjyendyh) View more | ||||||
Phase 4 | 274 | Prostaglandin insert dinoprostone (Cervical ripening balloon catheter (CRB)) | auvagwhzua(nzjmwggseq) = srwmgleucb iresnygeuo (kofhrlrzpe ) | - | 01 Jan 2020 | ||
Vaginal dinoprostone (Propess) | auvagwhzua(nzjmwggseq) = jdpfnuucov iresnygeuo (kofhrlrzpe ) | ||||||
Not Applicable | - | fyheigupwn(jlgqarprtn) = aglekrhnbv xptlcbokrt (ftoidpnezu ) View more | Positive | 15 Nov 2016 | |||
COX-2 inhibitor NS398 | fyheigupwn(jlgqarprtn) = pfpnwtwsho xptlcbokrt (ftoidpnezu ) View more |