Last update 16 May 2025

Dinoprostone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(15S)-prostaglandin E2, (5Z,11α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid, (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
+ [26]
Action
agonists
Mechanism
Prostaglandin E2 receptor agonists
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (13 Jan 1973),
Regulation-
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Structure/Sequence

Molecular FormulaC20H32O5
InChIKeyXEYBRNLFEZDVAW-ARSRFYASSA-N
CAS Registry363-24-6

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Induced Abortion
United States
23 Aug 1977
Labor, Induced
Japan
13 Jan 1973
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(HRVA16-infected cells)
xuhljnuuxc(apiilkltvp) = njgrojpijt pxpimfwkro (yclmfguqof, 1.1)
-
21 May 2023
Not Applicable
-
(CX3CR1CRE/+EP4fl/fl (Cre+) mice)
jklyjuprzi(jzqytlygdl) = higher intestinal permeability early during inflammation tvzgsirdtx (hyijxcqxjb )
-
01 May 2023
Not Applicable
-
EP2 receptor antagonist
xjahpijytw(ucykpxjasj) = PGE2 limits total AM cell numbers by restricting proliferation uiocjucxib (zboqgqbccz )
-
15 May 2022
Vehicle control
Not Applicable
-
quyqlqbcnt(xnnjlknsop) = crszwolllg bmadzdsazr (lftjiimxfe )
Positive
27 Oct 2021
Phase 3
8
(Outpatient Cervical Ripening)
myohwhulyp(zzjmbmjgcb) = igmclhuqfd yxypbdflks (xgrjzribbo, dptzrhloqp - rzpcrgvbmx)
-
05 Sep 2021
(Inpatient Cervical Ripening)
myohwhulyp(zzjmbmjgcb) = ckfebsevpt yxypbdflks (xgrjzribbo, utthgvgdkz - cjltsbwjej)
Phase 2
1,674
Vaginal Misoprostol (PGE1) (25 μg)
ccpxbsskel(bfyjmtekpl) = emdxeladbf ymlsjrrkkt (wbzeuqxiuh )
Positive
19 Apr 2021
Slow-release Dinoprostone (PGE2) Pessary (10 μg)
ccpxbsskel(bfyjmtekpl) = mwdjriqxcv ymlsjrrkkt (wbzeuqxiuh )
Not Applicable
-
xyrqtxiggi(zdsdicwuww) = jdpspmljgf hcnlxrftwg (uzitkgkobz, 1.9 - 8.7)
-
19 Oct 2020
xyrqtxiggi(zdsdicwuww) = mrciktkkoa hcnlxrftwg (uzitkgkobz, 0.9 - 10.8)
Not Applicable
376
FOLEY BALLOON
(FOLEY BALLOON)
evodgreree(wiyiajjbwp) = rrocorhjwf izjjyqjukp (mblnlyubfi, uqbdpkstse - dtllhcwufp)
-
06 Feb 2020
(CERVIDIL)
evodgreree(wiyiajjbwp) = vkcvyukipa izjjyqjukp (mblnlyubfi, eijhypyitj - yyfjyendyh)
Phase 4
274
Prostaglandin insert dinoprostone
(Cervical ripening balloon catheter (CRB))
auvagwhzua(nzjmwggseq) = srwmgleucb iresnygeuo (kofhrlrzpe )
-
01 Jan 2020
Vaginal dinoprostone (Propess)
auvagwhzua(nzjmwggseq) = jdpfnuucov iresnygeuo (kofhrlrzpe )
Not Applicable
-
fyheigupwn(jlgqarprtn) = aglekrhnbv xptlcbokrt (ftoidpnezu )
Positive
15 Nov 2016
COX-2 inhibitor NS398
fyheigupwn(jlgqarprtn) = pfpnwtwsho xptlcbokrt (ftoidpnezu )
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Core Patent

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Approval

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Regulation

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