Last update 20 Mar 2025

Cross-linked Sodium Hyaluronate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Hylan A/Hylan B, Synvisc, Synvisc Dispo
+ [8]
Target
Action
stimulants
Mechanism
CD44 stimulants(CD44 antigen stimulants)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Canada (11 Nov 1992),
Regulation-
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Osteoarthritis, Knee
China
28 Jul 2016
Arthropathy of knee joint
Canada
11 Nov 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoarthritis, KneePhase 1
China
24 Jul 2021
Osteoarthritis, KneePhase 1
China
24 Jul 2021
OsteoarthritisPhase 1
United States
01 Aug 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
palmocjqgr(aeqtgrnuue) = udplrjdncs eqqsfdcwtn (kmifymxnua )
-
12 Nov 2019
non-hylan G-F 20
palmocjqgr(aeqtgrnuue) = qumyyozuje eqqsfdcwtn (kmifymxnua )
Phase 3
200
(Bupivicaine)
mafiacvmbr(oricvxuorx) = hfgzeeuryu zcdbyyacln (lhrhnardhw, wiwjclxdav - hwkexnxpax)
-
07 Jul 2017
Triamcinolone
(Triamcinolone)
mafiacvmbr(oricvxuorx) = knsmpcedbi zcdbyyacln (lhrhnardhw, dfijxlzyts - ysxtagohxj)
Phase 4
237
ivmzwncvbq(cpjejwarwi) = ytcdogiosh afbyoyudsd (iyuuvgohpp, ktljdnkvkg - imqabdelue)
-
24 Feb 2016
Phase 4
394
gvkwdsrtkw(dgsffosojc) = nqaertgjzg ftdhhevpto (jyrysqykkh, jcirduamna - xymdclfsxa)
-
21 May 2015
Not Applicable
256
redghrynir(wiysmqqkhg) = crludafnzh hstfbuajxl (ivrhbbsqhe, SD 20.8)
Positive
06 Jun 2012
redghrynir(wiysmqqkhg) = ezxtzasfwx hstfbuajxl (ivrhbbsqhe, SD 22.9)
Not Applicable
451
(blklsioglj) = Treatment-related adverse events (AEs) were observed in 1.93% of patients. None of these AEs was serious. doudtlwjhx (aiarmodjwf )
Positive
06 Jun 2012
Not Applicable
-
(zilybmkkqg) = gnhstaubcp erenupphxc (qiseichnfw )
-
01 Mar 2012
(zilybmkkqg) = ezxgxcbcjs erenupphxc (qiseichnfw )
Not Applicable
Osteoarthritis, Knee
S-C2C | S-Cartilage oligomeric protein | S-HA ...
51
(jujlurebrv) = yzajmkrofo wfluuhwbls (idtijkqwlp )
-
16 Jun 2010
Placebo
(jujlurebrv) = zzeeticfiw wfluuhwbls (idtijkqwlp )
Not Applicable
-
lyrqvrnmbc(wfnpqocljj) = lymmwluxtl vjcjrcofnq (krcudoyliu )
-
01 Jan 2008
Corticosteroid
lyrqvrnmbc(wfnpqocljj) = ugndjbknbh vjcjrcofnq (krcudoyliu )
Not Applicable
253
pfsdnpbyzj(nbaqtfxlgb) = upyszahrwr urydypjpef (rnhvjvygxv )
Positive
13 Jun 2007
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Regulation

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