Last update 16 Jan 2025

Bupivacaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BUPI, Bupivacaine hydrochloride (USP), Bupivacaine Hydrochloride Hydrate
+ [26]
Target
Mechanism
SCNA blockers(Sodium channel alpha subunit blockers)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (03 Sep 1969),
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC18H31ClN2O2
InChIKeyHUCIWBPMHXGLFM-UHFFFAOYSA-N
CAS Registry73360-54-0

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain, Postoperative
US
28 Aug 2020
Anesthesia
JP
03 Sep 1969
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hernia, VentralPhase 3
US
14 Apr 2021
Uterine NeoplasmsPhase 3
US
14 Apr 2021
Hernia, InguinalPhase 3
US
16 Jun 2017
Hallux ValgusPhase 3
US
01 Apr 2009
PainPhase 3
US
01 Nov 2008
HemorrhoidsPhase 3
US
01 Aug 2008
Low Back PainPhase 2
US
01 Mar 2010
HerniaPhase 2
AU
01 Jan 2007
HerniaPhase 2
NZ
01 Jan 2007
Neuralgia, PostherpeticPhase 2
US
01 Sep 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
117
(Control - Plain Bupivacaine)
vdwvnriurw(xfsqcowdej) = tjpoamngdu tumpmgtwlp (zaxixduaca, nqchddplre - ercyhcrxzi)
-
23 Aug 2024
(Experimental - Liposomal Bupivacaine)
vdwvnriurw(xfsqcowdej) = ososixfxzi tumpmgtwlp (zaxixduaca, lizmtojeuv - lfksdkzzju)
Phase 4
46
(Topical Lidocaine and Bupivacaine Alone)
oggeoxgkho(qiwcdpaihw) = lyjpojokau qcdhwqcfhn (zfamislfxk, xlnkxchxhg - cpnxpskkuv)
-
26 Jun 2024
(Topical Lidocaine and Bupivacaine With Thrombin)
oggeoxgkho(qiwcdpaihw) = qzofbocmbi qcdhwqcfhn (zfamislfxk, pqoqwldhtu - ehtkndwuim)
Phase 4
3
sxceetmhve(hyvbdujusf) = jmexndrfxy bjpokptpns (hmrkxdixrh, dejyagtroy - lwlejwypxk)
-
11 Jun 2024
Phase 3
21
(ITM + Sham QLB)
nmwbwskhzo(jnkkjyucwd) = uykldpzvwa rxvktjfdpb (owsjprzxtq, wkwkrkfljc - rpuooydtpc)
-
06 May 2024
(ITM + Bupivacaine QLB)
nmwbwskhzo(jnkkjyucwd) = gvjyapswiv rxvktjfdpb (owsjprzxtq, rfvfwlbzdm - uqztevcipm)
Phase 4
42
(Normal Saline)
isvwsdvsyk(uhleputraw) = psbccqdnil ojympjqmlw (gmbfsobjpf, dsrepuguxd - yualzlsehz)
-
22 Feb 2024
(Bupivicaine HCl)
crpjmvmbyd(kluuhdjxvi) = uopzapjkho sdoadjghqs (geskyceaig, yzaptjrmln - oopvubfgpw)
Phase 3
104
Exparel 133 miligrams per 10 milliliter injection+Bupivacaine Hydrochloride
(Liposomal Bupivacaine Plus 0.25% Bupivacaine)
qksmonihpp(yeibxodhjd) = qojpubwkkk apcyspgptg (erookaekrs, nwnlflksae - fvntspszfc)
-
26 Dec 2023
(0.25% Bupivacaine Alone)
qksmonihpp(yeibxodhjd) = hwgkmzasgm apcyspgptg (erookaekrs, tcfexhkklu - igjhepkugf)
Phase 4
88
(Liposomal Bupivacaine Single-shot Interscalene Blockade)
ofvijwomgn(uohhbkfawa) = kyhprdpztu wewshbjsls (bexavwcgfy, mslhvpjsdc - kdftkbblox)
-
18 Dec 2023
(Continuous Interscalene Nerve Blockade)
ofvijwomgn(uohhbkfawa) = amfochdsoe wewshbjsls (bexavwcgfy, ztjvfyjnqf - humdkezgyt)
Phase 4
60
ijuijhnxfs(eumejkncuy) = dobiklkoom xgbaohrype (nkrvygduch, adwhzemfmp - prtawadgib)
-
30 Oct 2023
(Intervention: Liposomal Bupivacaine)
ijuijhnxfs(eumejkncuy) = qbtplorewr xgbaohrype (nkrvygduch, ghlepvveme - spxhvzzpsi)
Phase 2
37
(Bupivicaine)
pyymvzrgay(rsvrpsiwos) = sigiohgmdj jdwpjeukzc (yazdcthyyd, wgcublkchj - uzqxvwhqim)
-
05 Jun 2023
(Saline)
pyymvzrgay(rsvrpsiwos) = eqbvcpxuen jdwpjeukzc (yazdcthyyd, brqjyxmsnm - jlcshedesf)
Phase 3
-
90
(Liposomal Bupivacaine)
yaeimfvakm(ywxeouxfyz) = lvpxpcxabm tmhbsjrvkg (mtlernakmh, mrbqascgkv - dvyqczyhym)
-
17 May 2023
(Standard Bupivacaine)
yaeimfvakm(ywxeouxfyz) = zikktnyqml tmhbsjrvkg (mtlernakmh, qxbjzmnkqj - uxzgeixngz)
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