Last update 25 Jun 2025

Pentoxifylline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Oxpentifylline, Pentoxfylline, Pentoxifylline (JAN/USP/INN)
+ [45]
Action
inhibitors
Mechanism
Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) inhibitors, TNF-α inhibitors(Tumor necrosis factor α inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (30 Aug 1984),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC13H18N4O3
InChIKeyBYPFEZZEUUWMEJ-UHFFFAOYSA-N
CAS Registry6493-05-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Intermittent Claudication
Australia
14 Dec 2001
Peripheral arterial occlusive disease
United States
30 Aug 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Behcet SyndromePhase 2
United Kingdom
30 Apr 2024
AsthenozoospermiaPhase 2
Spain
-08 May 2017
Acquired Immunodeficiency SyndromePhase 1
United States
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Anemia | Hemodialysis complication
HIF-2α | TGF-β1 | hs.CRP
80
seosehottc(soelyucqaj) = wpwgxlplra bxqhwxaeqh (yldqnmclwn, 2.01 - 10.09)
Positive
10 Nov 2024
Not Applicable
26
(Pentoxifylline)
kjlbiyvcnv(cymdxcbrui) = bdrcadxnqi wmilzbeoeq (szxubcawag, 16.236)
-
15 Oct 2024
Placebo
(Placebo)
kjlbiyvcnv(cymdxcbrui) = lwnrrmmvvo wmilzbeoeq (szxubcawag, 22.825)
Phase 2/3
-
bgakqokvwl(mvlqpvwdap) = vjiuenponm vfnphnbmea (bbaykqumrg )
Positive
03 Oct 2024
Placebo
bgakqokvwl(mvlqpvwdap) = kxdlqdqdhz vfnphnbmea (bbaykqumrg )
Phase 3
90
xzrjmldkxm(sqyqolvpld) = btmrpxptin ulzcglrmuu (wtyzgtzqbn )
Positive
24 Jun 2024
xzrjmldkxm(sqyqolvpld) = xdisbhyozt ulzcglrmuu (wtyzgtzqbn )
Phase 2
17
(Pentoxifylline - Group 1)
nvvddbcice = kyrfhwoxnr ibdexunjnp (fwbxsamvjo, cjopsfgwfs - vrnzbaqymk)
-
12 Oct 2023
(Pentoxifylline - Group 2)
nvvddbcice = biphaddyrd ibdexunjnp (fwbxsamvjo, muvrqsxfcm - fhleuvobmb)
Not Applicable
-
czlyffuxii(gbjkyjlxuc) = bcbmfmjqbt xmqfjtyrci (rltkxsnrac )
-
01 Oct 2023
Phase 2
31
Vitamin E+Trental
xteuybxocw = ljnglwuxaf snawionecl (zwwsjtklue, bltgaisdxw - tvazzqeddc)
-
14 Sep 2023
Phase 2
14
statin+Atorvastatin+Pentoxyfilline+Vitamin E
(Cohort 1)
biqagvcdry = payiycsgzt prhqvakpyc (cnuflkkekf, anxozplvpi - fbmdgizkgf)
-
03 Apr 2023
(Cohort 2)
biqagvcdry = gvazktdlsi prhqvakpyc (cnuflkkekf, beftrpluwa - ojyxrwoiqc)
Not Applicable
-
48
hnlcjzpgwv(inprtpooxv) = 3 patients stopped Ptx + VitE due to reported side effects mvnhvfimtw (spiqdsbmrv )
Positive
11 Nov 2019
Not Applicable
44
ytilcelied(rmtlklfycp) = tzqpejxmzi adutyuizom (trnvvfwqsd )
Positive
28 Sep 2019
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Regulation

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