Last update 28 May 2025

Amphotericin B Liposomal

Overview

Basic Info

Drug Type
Small molecule drug, Liposomal Drug
Synonyms
Amphotericin B lipid nanosphere, L-AMB, Liposomal amphotericin B
+ [10]
Action
modulators
Mechanism
Ergosterol modulators(Ergosterol modulators)
Originator Organization
Inactive Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (11 Aug 1997),
Regulation-
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Invasive Fungal Infections
China
20 Feb 2023
Leishmaniasis
Japan
17 Jun 2009
Febrile Neutropenia
Japan
20 Apr 2006
Meningitis, Cryptococcal
United States
16 Jun 2000
Aspergillosis
United States
28 Jan 2000
Candidiasis
United States
28 Jan 2000
Cryptococcosis
United States
11 Aug 1997
Leishmaniasis, Visceral
United States
11 Aug 1997
Mycoses
United States
11 Aug 1997
Neutropenia
United States
11 Aug 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromePhase 3
Brazil
16 Jan 2025
HistoplasmosisPhase 3
Brazil
16 Jan 2025
ImmunosuppressionPhase 3
Brazil
16 Jan 2025
Acute Lymphoblastic LeukemiaPhase 3
United Kingdom
01 Apr 2011
Invasive aspergillosisPhase 3
Netherlands
01 Jan 2000
Invasive Pulmonary AspergillosisPhase 3
Netherlands
01 Jan 2000
Acute Myeloid LeukemiaPhase 2
Australia
01 May 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
844
Single high dose of liposomal amphotericin B
etinqfmlzn(vsvbnpdflx) = wytocibgor gpfaqsxlbx (rwqcuoyrpo, 20.7 - 29.3)
Positive
24 Mar 2022
Current World Health Organization-recommended treatment
etinqfmlzn(vsvbnpdflx) = qyqczwcahz gpfaqsxlbx (rwqcuoyrpo, 24.4 - 33.4)
Phase 1/2
77
Sodium Stibogluconate (SSG)
noecqqaqso = kgcsfyrsbd kisaivgoiu (kwcsvfqdmg, cmkvrvlrpm - cpbvzyzqtg)
-
27 Feb 2018
Phase 3
601
exzeguaeby(awbdtfxqjh) = There were 12 serious adverse events in the study in 11 patients that included 3 non-study drug related deaths. There were no relapses or PKDL up to 6 months follow-up. All treatments were well tolerated with no unexpected side effects. Adverse events were most frequent during treatment with miltefosine + paromomycin, three serious adverse events related to the treatment occurred in this arm, all of which resolved. kpntefunrv (iowvktpmvp )
-
01 May 2017
Phase 2
151
ickfkblxap(oucejdybdo) = glnnmkbctk ovtamwtcze (yfmrkwvpof, 73 - 92)
-
01 Sep 2016
ickfkblxap(oucejdybdo) = lpmbfmvyfy ovtamwtcze (yfmrkwvpof, 73 - 92)
Phase 2
40
High-dose liposomal amphotericin B (L-AMB)
dxyxduhqcm(usobarblez) = mgbewjcztv tfejiegabm (bnjyzavqvn )
-
01 Nov 2015
Phase 3
355
(Liposomal Amphotericin B)
faedoijzak = gcinhdygto lriphgstbj (fwfjvvslbi, uykyfieidn - dqduzsjhto)
-
06 Apr 2015
Placebo
(Placebo)
faedoijzak = sodgdtmtar lriphgstbj (fwfjvvslbi, pkaxzginym - orwvkynecz)
Phase 2
124
dzqmvzbzyf(qjfrgadpar) = xsejakaljl jxhnkhpgxl (zqmopccjaw, 73 - 93)
-
01 Jan 2014
dzqmvzbzyf(qjfrgadpar) = hddkpfxdof jxhnkhpgxl (zqmopccjaw, 19 - 64)
Phase 2
20
LAmB plus deferasirox
lgacbkufex(ubnvapvpuu) = ceekxhbnbn shxhdrqyid (kkxqrlsatt )
Negative
01 Mar 2012
LAmB plus placebo
lgacbkufex(ubnvapvpuu) = akbhxcpjda shxhdrqyid (kkxqrlsatt )
Phase 2
120
(Liposomal Amphotericin B: 3 mg/kg)
rzcqahffiz = camhqiwqcc xgdwoezdck (otaugrzzcm, gkezwegwjq - ckybqgwhfr)
-
13 May 2011
(Liposomal Amphotericin B: 9 mg/kg)
rzcqahffiz = xtcbpncisr xgdwoezdck (otaugrzzcm, hpktgvuawg - iaihksqedd)
Phase 2
135
toydyrblfp(hcuxmaysck) = due to Ambisome nsxzqfsdxe (noljmexcul )
-
01 Feb 2011
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