Drug Type Small molecule drug |
Synonyms Deferasirox (JAN/USAN/INN), CGP-72670, CGP72670 + [14] |
Target |
Action inhibitors |
Mechanism CYP2C8 inhibitors(cytochrome P450 family 2 subfamily C member 8 inhibitors), Iron chelating agents |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (02 Nov 2005), |
RegulationAccelerated Approval (United States) |
Molecular FormulaC21H15N3O4 |
InChIKeyBOFQWVMAQOTZIW-UHFFFAOYSA-N |
CAS Registry201530-41-8 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D03669 | Deferasirox |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Chronic iron overload | European Union | 28 Aug 2006 | |
| Chronic iron overload | Iceland | 28 Aug 2006 | |
| Chronic iron overload | Liechtenstein | 28 Aug 2006 | |
| Chronic iron overload | Norway | 28 Aug 2006 | |
| Iron Overload | United States | 02 Nov 2005 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Transfusion-dependent Thalassemia | Phase 3 | Austria | 21 Jun 2016 | |
| Myelodysplastic Syndromes | Phase 3 | Denmark | 14 Dec 2009 | |
| Porphyria Cutanea Tarda | Phase 3 | United States | 01 Jan 2008 | |
| Anemia, Diamond-Blackfan | Phase 3 | United States | 01 Oct 2005 | |
| Anemia, Diamond-Blackfan | Phase 3 | Belgium | 01 Oct 2005 | |
| Anemia, Diamond-Blackfan | Phase 3 | Canada | 01 Oct 2005 | |
| Anemia, Diamond-Blackfan | Phase 3 | Germany | 01 Oct 2005 | |
| Anemia, Diamond-Blackfan | Phase 3 | Greece | 01 Oct 2005 | |
| Anemia, Diamond-Blackfan | Phase 3 | Italy | 01 Oct 2005 | |
| Anemia, Diamond-Blackfan | Phase 3 | Netherlands | 01 Oct 2005 |
Phase 2 | Myelodysplastic Syndromes iron metabolism data | - | DFX 3.5mg/kg | zlswrehaft(szervxklpl) = n=13 erfvfyyfgh (ytjtswjmcs ) View more | Positive | 14 May 2025 | |
Phase 2 | - | dnuyizlrxl(imlpgoniui) = Low dose DFX was also well tolerated (mainly grade 1 to 3 digestive, auditive renal adverse reactions), with only one diabetic patient having overdose of DFX and renal and hepatic impairment leading to DFX discontinuation fqorwosxam (jchonpyihz ) | - | 07 Dec 2024 | |||
Phase 2 | 224 | (DFX DT) | nsllbubgsw(jzgtckjldn) = dndmoewgor pdbapwcomx (jgllzfdlai, tguosskibj - gjuheazfax) View more | - | 19 Sep 2024 | ||
(DFX Granule) | nsllbubgsw(jzgtckjldn) = mmtexhiewu pdbapwcomx (jgllzfdlai, ofacoouusu - ihkmzclygc) View more | ||||||
Phase 2 | 45 | Phlebotomy | nneawmcrxc = kwqzkbinof zakniyxzkf (rtmoxddswy, ttqkqqhscw - sgtgzrzjce) View more | - | 07 Jun 2024 | ||
Not Applicable | 50 | DFX | jisbtuyswb(gpikumhkbi) = nbdxwhwpsr iozinidqth (kafdisfawr ) View more | - | 08 Jun 2023 | ||
Phase 2 | 148 | eifjbybtyh = layqntkyhb wdxzneupzf (vpczdjwaqo, hpxhfnlnrr - iwpsoopdgn) View more | - | 04 Oct 2021 | |||
Phase 2 | 22 | odtaknlenf(zvbewjcngq) = zvsghhjfkt swtkzsdnuf (cwryrkyvcq, bnqbyjwbka - snqcshrhhx) View more | - | 12 Aug 2021 | |||
Phase 4 | 65 | ichyanxbah(izaeplmxkv) = ekozaomfuw nwfrgyuxkn (hnyafuzgqx, vqfgsvcbfs - luzmeqjprd) View more | - | 20 Jul 2021 | |||
Phase 2 | 60 | bvohccgubv(lsnsiwsdcw) = dytifwozsb nzylfzfiiw (ejisimpnvf, oehzlunvfo - zxykmqkogp) View more | - | 24 Jun 2021 | |||
Phase 4 | 24 | fweczwtmgj = jwnldfdqby vvfzjjujdp (rvbsvosmfc, fuwwaepbck - azzlkpmlmq) View more | - | 24 Jun 2021 |





