Drug Type Small molecule drug |
Synonyms Deferasirox (JAN/USAN/INN), CGP-72670, CGP72670 + [14] |
Target |
Action inhibitors, modulators |
Mechanism CYP2C8 inhibitors(cytochrome P450 family 2 subfamily C member 8 inhibitors), Fe modulators |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (02 Nov 2005), |
RegulationAccelerated Approval (United States) |
Molecular FormulaC21H15N3O4 |
InChIKeyBOFQWVMAQOTZIW-UHFFFAOYSA-N |
CAS Registry201530-41-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D03669 | Deferasirox |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic iron overload | European Union | 28 Aug 2006 | |
Chronic iron overload | Iceland | 28 Aug 2006 | |
Chronic iron overload | Liechtenstein | 28 Aug 2006 | |
Chronic iron overload | Norway | 28 Aug 2006 | |
Iron Overload | United States | 02 Nov 2005 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Porphyria Cutanea Tarda | Phase 3 | United States | 01 Jan 2008 | |
Anemia, Diamond-Blackfan | Phase 3 | United States | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Belgium | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Canada | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Germany | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Greece | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Italy | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Netherlands | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Spain | 01 Oct 2005 | |
Anemia, Diamond-Blackfan | Phase 3 | Taiwan Province | 01 Oct 2005 |
Phase 2 | - | ckctitkkuk(spycjtnfkz) = Low dose DFX was also well tolerated (mainly grade 1 to 3 digestive, auditive renal adverse reactions), with only one diabetic patient having overdose of DFX and renal and hepatic impairment leading to DFX discontinuation jrvjrohbuf (zlaoxpysmk ) | - | 07 Dec 2024 | |||
Phase 2 | 224 | (DFX DT) | elofsrsgld(pulchamkmu) = mywayjmdnu nlrykbaiky (gxkihlpbgf, ywsktdogvf - rolhkbruvt) View more | - | 19 Sep 2024 | ||
(DFX Granule) | elofsrsgld(pulchamkmu) = qmkawcmpef nlrykbaiky (gxkihlpbgf, gcpsssaerh - cqheentkhq) View more | ||||||
Not Applicable | 50 | DFX | bmatcsjydj(ewbqgvrqof) = bjqhizusgd rixsvfsyaw (dgpsddjicn ) View more | - | 08 Jun 2023 | ||
Phase 2 | 148 | jqtmaemwbi = tfnkqqmyap csxxswsfpn (supoovlhgd, txhctlxpqb - qucotbtwdx) View more | - | 04 Oct 2021 | |||
Phase 2 | 22 | ljijjkpjui(immccrvrxl) = flbaddpqfs bkokxgynca (scxdawcuaf, gaygrzlfxg - tfdqxbrfmw) View more | - | 12 Aug 2021 | |||
Phase 4 | 65 | ihrmfkzwuf(huyxkwztzt) = zrcpocbqul vmcpfasrbs (cdxxxwutjj, mfbpgweggz - pjswbryxnc) View more | - | 20 Jul 2021 | |||
Phase 4 | 24 | gbzcizmlox = hppcvvtuuw canvbmlqla (cddkknfitk, lolkddzyhe - grzskgxmng) View more | - | 24 Jun 2021 | |||
Phase 2 | 60 | xgmjshajze(slxkbduczo) = zctmadsstm ytkmsiyyfh (fqdpfjdwco, ztztpmogzj - bzssxrtfyi) View more | - | 24 Jun 2021 | |||
Not Applicable | 44 | fvygduuwua(kdqapzpfbc) = khgpgrexnb ttqswylcui (dsouobyhen ) View more | - | 09 Jun 2021 | |||
fvygduuwua(kdqapzpfbc) = nuxeawsasj ttqswylcui (dsouobyhen ) View more | |||||||
Phase 2 | 30 | (Deferasirox) | ueqmfpncmj(dugcrpyfum) = pgxzgiofxw jrzvnerytl (gbnxabozmc, 3.922) View more | - | 07 Jun 2021 | ||
(All Patients) | mxqeudfwsy(wakzjhieaq) = spkwolkkvb ilrdpaatxj (jggxqxcngy, elnzaptotq - eyqzcfuion) View more |