Delving into the Latest Updates on Travoprost/Timolol Maleate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

DuoTrav APS, DuoTrav BAK, DuoTrav PQ

+ [11]

Target

PTGFR x β-adrenoceptors

Mechanism

PTGFR agonists(Prostanoid FP receptor agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)

Therapeutic Areas

Eye Diseases

Active Indication

GlaucomaGlaucoma, Open-AngleOcular Hypertension

Inactive Indication-

Originator Organization

Alcon AG

Active Organization

Novartis Europharm Ltd.

Novartis Pharmaceuticals Corp.

Inactive Organization

Alcon Research Ltd.

Drug Highest PhaseApproved

First Approval Date

EU (23 Apr 2006),

Glaucoma, Open-AngleOcular Hypertension

Regulation-

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Structure

Molecular FormulaC39H59F3N4O9S

InChIKeyKJNUGXGYVXURJB-DDANCUEQSA-N

CAS Registry874755-80-3

The purpose of this study is to assess efficacy and tolerability of changing to DuoTrav® (Travoprost 0.004%/Timolol 0.5% BAK-free) from prior Xalacom® or Ganfort® fixed combination pharmacotherapy in patients with open-angle glaucoma or ocular hypertension with uncontrolled intraocular pressure (IOP).

Start Date01 Jun 2012

Sponsor / Collaborator

Alcon Research Ltd.

100 Clinical Results associated with Travoprost/Timolol Maleate

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100 Translational Medicine associated with Travoprost/Timolol Maleate

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100 Patents (Medical) associated with Travoprost/Timolol Maleate

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75

Literatures (Medical) associated with Travoprost/Timolol Maleate

05 Sep 2022·Journal of epidemiologyQ3 · MEDICINE

Association of the Time to First Cigarette and the Prevalence of Chronic Respiratory Diseases in Chinese Elderly Population

Q3 · MEDICINE

ArticleOA

Author: Lou, Yiling ; Jiang, Heng ; Guo, Yingying ; Tian, Qingfeng ; Cao, Shiyi ; Gan, Yong ; Zhu, Yi ; Wang, Chao ; Lu, Zuxun

BACKGROUND:

Increasing number of studies have suggested the time to first cigarette after waking (TTFC) have significant positive effect on respiratory diseases. However, few of them focused on the Chinese population. This study aims to estimate the impact of TTFC on the prevalence of chronic respiratory diseases (CRD) in Chinese elderly and explore the association in different sub-populations.

METHODS:

Cross-sectional data of demographic characteristics, living environment, smoking-related variables, and CRD were drawn from the Chinese Longitudinal Healthy Longevity Survey in 2018. Multivariate stepwise logistic regression analyses were conducted to examine the association of the TTFC with the prevalence of CRD.

RESULTS:

This study includes 13,208 subjects aged 52 years and older, with a mean age of 85.3 years. Of them, 3,779 participants were ex- or current smokers (44.9% had the TTFC ≤30 minutes, 55.1% >30 minutes) and 1,492 had suffered from CRD. Compared with non-smokers, participants with TTFC ≤30 minutes seemed to have higher prevalence of CRD (OR 1.97; 95% CI, 1.65-2.35) than those with TTFC >30 minutes (OR 1.70; 95% CI, 1.44-2.00), although the difference was statistically insignificant (P_interaction = 0.12). Compared with TTFC >30 minutes, TTFC ≤30 minutes could drive a higher prevalence of CRD among female participants, those aged 90 years and older, urban residents, and ex-smokers (P_interaction < 0.05).

CONCLUSION:

Shorter TTFC relates to higher prevalences of CRD in Chinese older females, those aged 90 years and older, urban residents, and ex-smokers. Delaying TTFC might partially reduce its detrimental impact on respiratory disease in these specific subpopulations.

01 Dec 2020·Microbial cell factoriesQ2 · ENGINEERING & TECHNOLOGY

A probiotic treatment increases the immune response induced by the nasal delivery of spore-adsorbed TTFC

Q2 · ENGINEERING & TECHNOLOGY

ArticleOA

Author: Baccigalupi, Loredana ; Isticato, Rachele ; Mazzoli, Arianna ; Santos, Francisco Denis S ; Iossa, Susanna ; Ricca, Ezio ; Maia, Ana Raquel ; Saggese, Anella ; Leite, Fabio

Abstract:

Background:

Spore-forming bacteria of the Bacillus genus are widely used probiotics known to exert their beneficial effects also through the stimulation of the host immune response. The oral delivery of B. toyonensis spores has been shown to improve the immune response to a parenterally administered viral antigen in mice, suggesting that probiotics may increase the efficiency of systemic vaccines. We used the C fragment of the tetanus toxin (TTFC) as a model antigen to evaluate whether a treatment with B. toyonensis spores affected the immune response to a mucosal antigen.

Results:

Purified TTFC was given to mice by the nasal route either as a free protein or adsorbed to B. subtilis spores, a mucosal vaccine delivery system proved effective with several antigens, including TTFC. Spore adsorption was extremely efficient and TTFC was shown to be exposed on the spore surface. Spore-adsorbed TTFC was more efficient than the free antigen in inducing an immune response and the probiotic treatment improved the response, increasing the production of TTFC-specific secretory immunoglobin A (sIgA) and causing a faster production of serum IgG. The analysis of the induced cytokines indicated that also the cellular immune response was increased by the probiotic treatment. A 16S RNA-based analysis of the gut microbial composition did not show dramatic differences due to the probiotic treatment. However, the abundance of members of the Ruminiclostridium 6 genus was found to correlate with the increased immune response of animals immunized with the spore-adsorbed antigen and treated with the probiotic.

Conclusion:

Our results indicate that B. toyonensis spores significantly contribute to the humoral and cellular responses elicited by a mucosal immunization with spore-adsorbed TTFC, pointing to the probiotic treatment as an alternative to the use of adjuvants for mucosal vaccinations.

01 Sep 2020·Journal of addiction medicineQ3 · MEDICINE

Time to First Cigarette: A Potential Clinical Screening Tool for Nicotine Dependence

Q3 · MEDICINE

Review

Author: Joshua E Muscat ; Melissa Mercincavage ; Steven A Branstetter

Objectives::

The time to first cigarette (TTFC) of the day has been identified as the best single-item indicator of nicotine dependence. However, TTFC has not been extensively used in clinical settings and is not a criterion for tobacco use disorder, perhaps due to a lack of information about TTFC's predictive value. This review provides a synthesis of the accumulating literature on TTFC's relationships with nicotine dependence, identify gaps, and inform future clinical and epidemiologic research of potential uses of TTFC.

Methods::

A systematic review of the literature was conducted using PubMed, Google Scholar, and Web of Science ISI databases. We identified 16 articles examining the relation between TTFC and negative outcomes associated with high levels of nicotine addiction and Tobacco Use Disorders (eg, high levels of nicotine and toxicant exposure, progressive use over time, failed cessation, head-and-neck cancers).

Results::

Earlier TTFC was consistently associated with greater likelihood of cessation failure and relapse, and higher levels of biomarkers of tobacco exposure. Several of these associations were found among both adult and adolescent smokers, and remained even after accounting for smoking behaviors (eg, cigarettes/day).

Conclusions::

Earlier TTFC is a key indicator of greater nicotine dependence. Knowledge of a smoker's TTFC may allow clinicians to accurately inform smokers of health risks and assign greater resources during cessation attempts. Smokers may be able to use TTFC to self-select cessation aids and accurately assess their unique smoking-related health risks. TTFC may be a better item than cigarettes/day for accurately quantifying dependence and risk in epidemiologic studies.

2

News (Medical) associated with Travoprost/Timolol Maleate

06 Sep 2022

·www.globenewswire.com

Eyenovia to Participate in Multiple Medical Meetings in September

NEW YORK, Sept. 06, 2022 (GLOBE NEWSWIRE) -- Eyenovia, Inc. (NASDAQ: EYEN), an ophthalmic pharmaceutical technology company developing a pipeline of late-stage microdose array print (MAP™) therapeutics, today announced that the company will be participating in multiple medical meetings in September. Details of the presentations are as follows: Meeting: Ophthalmology Futures European Forum 2022Title: The Optejet – Advancing Drug Delivery and Improving Patient ExperiencePresenter: Beth Scott, OD, VP, Regulatory and Medical AffairsDate: Thursday, September 15, 2022Location: Principe di Savoia, Milan, Italy Meeting: The T.H.E. Summit by Treehouse EyesTitle: Drug/Device Technology to Improve Pediatric Progressive Myopia TreatmentPresenter: Michael Rowe, Chief Executive OfficerDate: September 15, 2022Location: Caesars, Las Vegas, NV Meeting: 40th Congress of the European Society of Cataract and Refractive Surgeons (ESCRS) 2022Title: In Vitro Cell Toxicity Comparing Microdose vs Drop Delivery of Latanoprost with BAK in Human Conjunctival CellsPresenter: Pedram Hamrah, MD, FACS, Department of Ophthalmology, Tufts Medical CenterDate: September 16-20, 2022Format: ePoster presentation, accessible for the duration of the conferenceLocation: Milano Convention Centre, Milan, Italy Meeting: Eyecelerator at AAO 2022Title: The Optejet® | The First and Only Human-Centric Ophthalmic Topical Medication DevicePresenter: Michael Rowe, Chief Executive OfficerDate: Thursday, September 29, 2022Location: McCormick Place, Chicago, Il About Eyenovia, Inc.Eyenovia, Inc. (NASDAQ: EYEN) is an ophthalmic pharmaceutical technology company developing a pipeline of microdose array print (MAPTM) therapeutics. Eyenovia is currently focused on the late-stage development of microdosed medications for mydriasis, presbyopia and myopia progression. For more information, visit Eyenovia.com. The Eyenovia Corporate Information slide deck may be found at ir.eyenovia.com/events-and-presentations. Forward-Looking StatementsExcept for historical information, all of the statements, expectations and assumptions contained in this press release are forward-looking statements. Forward-looking statements include, but are not limited to, statements that express our intentions, beliefs, expectations, strategies, predictions or any other statements relating to our future activities or other future events or conditions, including estimated market opportunities for our product candidates and platform technology. These statements are based on current expectations, estimates and projections about our business based, in part, on assumptions made by management. These statements are not guarantees of future performance and involve risks, uncertainties and assumptions that are difficult to predict. Therefore, actual outcomes and results may, and in some cases are likely to, differ materially from what is expressed or forecasted in the forward-looking statements due to numerous factors discussed from time to time in documents which we file with the U.S. Securities and Exchange Commission. In addition, such statements could be affected by risks and uncertainties related to, among other things: risks of our clinical trials, including, but not limited to, the costs, design, initiation and enrollment (which could still be adversely impacted by COVID-19 and resulting social distancing), timing, progress and results of such trials; the timing of, and our ability to submit applications for, obtaining and maintaining regulatory approvals for our product candidates; the potential impacts of COVID-19 on our supply chain; the potential advantages of our product candidates and platform technology; the rate and degree of market acceptance and clinical utility of our product candidates; our estimates regarding the potential market opportunity for our product candidates; reliance on third parties to develop and commercialize our product candidates; the ability of us and our partners to timely develop, implement and maintain manufacturing, commercialization and marketing capabilities and strategies for our product candidates; intellectual property risks; changes in legal, regulatory and legislative environments in the markets in which we operate and the impact of these changes on our ability to obtain regulatory approval for our products; and our competitive position. Any forward-looking statements speak only as of the date on which they are made, and except as may be required under applicable securities laws, Eyenovia does not undertake any obligation to update any forward-looking statements. Eyenovia Contact:Eyenovia, Inc.John GandolfoChief Financial Officerjgandolfo@eyenovia.com Eyenovia Investor Contact:Eric RibnerLifeSci Advisors, LLCeric@lifesciadvisors.com(646) 751-4363 Eyenovia Media Contact:Eyenovia, Inc.Norbert LoweVice President, Commercial Operationsnlowe@eyenovia.com

06 Sep 2022

·www.biospace.com

Eyenovia to Participate in Multiple Medical Meetings in September 2022

NEW YORK, Sept. 06, 2022 (GLOBE NEWSWIRE) -- Eyenovia, Inc. (NASDAQ: EYEN), an ophthalmic pharmaceutical technology company developing a pipeline of late-stage microdose array print (MAP™) therapeutics, today announced that the company will be participating in multiple medical meetings in September. Details of the presentations are as follows: Meeting: Ophthalmology Futures European Forum 2022 Title: The Optejet – Advancing Drug Delivery and Improving Patient Experience Presenter: Beth Scott, OD, VP, Regulatory and Medical Affairs Date: Thursday, September 15, 2022 Location: Principe di Savoia, Milan, Italy Meeting: The T.H.E. Summit by Treehouse Eyes Title: Drug/Device Technology to Improve Pediatric Progressive Myopia Treatment Presenter: Michael Rowe, Chief Executive Officer Date: September 15, 2022 Location: Caesars, Las Vegas, NV Meeting: 40th Congress of the European Society of Cataract and Refractive Surgeons (ESCRS) 2022 Title: In Vitro Cell Toxicity Comparing Microdose vs Drop Delivery of Latanoprost with BAK in Human Conjunctival Cells Presenter: Pedram Hamrah, MD, FACS, Department of Ophthalmology, Tufts Medical Center Date: September 16-20, 2022 Format: ePoster presentation, accessible for the duration of the conference Location: Milano Convention Centre, Milan, Italy Meeting: Eyecelerator at AAO 2022 Title: The Optejet® | The First and Only Human-Centric Ophthalmic Topical Medication Device Presenter: Michael Rowe, Chief Executive Officer Date: Thursday, September 29, 2022 Location: McCormick Place, Chicago, Il About Eyenovia, Inc. Eyenovia, Inc. (NASDAQ: EYEN) is an ophthalmic pharmaceutical technology company developing a pipeline of microdose array print (MAPTM) therapeutics. Eyenovia is currently focused on the late-stage development of microdosed medications for mydriasis, presbyopia and myopia progression. For more information, visit Eyenovia.com. The Eyenovia Corporate Information slide deck may be found at ir.eyenovia.com/events-and-presentations. Forward-Looking Statements Except for historical information, all of the statements, expectations and assumptions contained in this press release are forward-looking statements. Forward-looking statements include, but are not limited to, statements that express our intentions, beliefs, expectations, strategies, predictions or any other statements relating to our future activities or other future events or conditions, including estimated market opportunities for our product candidates and platform technology. These statements are based on current expectations, estimates and projections about our business based, in part, on assumptions made by management. These statements are not guarantees of future performance and involve risks, uncertainties and assumptions that are difficult to predict. Therefore, actual outcomes and results may, and in some cases are likely to, differ materially from what is expressed or forecasted in the forward-looking statements due to numerous factors discussed from time to time in documents which we the U.S. Securities and Exchange Commission. In addition, such statements could be affected by risks and uncertainties related to, among other things: risks of our clinical trials, including, but not limited to, the costs, design, initiation and enrollment (which could still be adversely impacted by COVID-19 and resulting social distancing), timing, progress and results of such trials; the timing of, and our ability to submit applications for, obtaining and maintaining regulatory approvals for our product candidates; the potential impacts of COVID-19 on our supply chain; the potential advantages of our product candidates and platform technology; the rate and degree of market acceptance and clinical utility of our product candidates; our estimates regarding the potential market opportunity for our product candidates; reliance on third parties to develop and commercialize our product candidates; the ability of us and our partners to timely develop, implement and maintain manufacturing, commercialization and marketing capabilities and strategies for our product candidates; intellectual property risks; changes in legal, regulatory and legislative environments in the markets in which we operate and the impact of these changes on our ability to obtain regulatory approval for our products; and our competitive position. Any forward-looking statements speak only as of the date on which they are made, and except as may be required under applicable securities laws, Eyenovia does not undertake any obligation to update any forward-looking statements. Eyenovia Contact: Eyenovia, Inc. John Gandolfo Chief Financial Officer jgandolfo@eyenovia.com Eyenovia Investor Contact: Eric Ribner LifeSci Advisors, LLC eric@lifesciadvisors.com (646) 751-4363 Eyenovia Media Contact: Eyenovia, Inc. Norbert Lowe Vice President, Commercial Operations nlowe@eyenovia.com

100 Deals associated with Travoprost/Timolol Maleate

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	S01ED51	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Glaucoma	JP	Novartis Pharmaceuticals Corp.	16 Apr 2010
Glaucoma, Open-Angle	EU	Novartis Europharm Ltd.	23 Apr 2006
Glaucoma, Open-Angle	IS	Novartis Europharm Ltd.	23 Apr 2006
Glaucoma, Open-Angle	LI	Novartis Europharm Ltd.	23 Apr 2006
Glaucoma, Open-Angle	NO	Novartis Europharm Ltd.	23 Apr 2006
Ocular Hypertension	EU	Novartis Europharm Ltd.	23 Apr 2006
Ocular Hypertension	IS	Novartis Europharm Ltd.	23 Apr 2006
Ocular Hypertension	LI	Novartis Europharm Ltd.	23 Apr 2006
Ocular Hypertension	NO	Novartis Europharm Ltd.	23 Apr 2006

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02730871 (CTgov)	Phase 4	Glaucoma, Open-Angle	173	Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension+Travoprost 0.004%/timolol 0.5% solution (Simbrinza + Duotrav)	ihxgyxnqgz(jxolkjiuky) = jeuejdsmdt qpicdwldqz (vwohukrfbh, nzmzuutymt - rgtlpcugle) View more	-	17 May 2019
				Brinzolamide/brimonidine vehicle+Travoprost 0.004%/timolol 0.5% solution (Vehicle + Duotrav)	ihxgyxnqgz(jxolkjiuky) = igsdnkhvki qpicdwldqz (vwohukrfbh, nlvygitjfx - zwshvespor) View more
NCT02003391 (Pubmed \| J Ophthalmol) Manual	Phase 4	Glaucoma, Open-Angle \| Ocular Hypertension	156	Travoprost+Timolol	ylaxqefpei(pjmpcpsuzt) = guhybqphij ilicyzqwfl (dbizrbktuo, 3.1) View more	Positive	01 Jan 2017
				beta-blocker monotherapy+Travoprost+Timolol	ylaxqefpei(pjmpcpsuzt) = alujrpoxid ilicyzqwfl (dbizrbktuo, 3.1) View more
NCT02003391 (CTgov)	Phase 4	Glaucoma, Open-Angle	157	Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution (DuoTrav)	ilgwtphvhm(xzbnmndlry) = eblitarjoj ofgdkanpsz (ltnrefqwxl, nvlpqlemna - fiiquaxsqe) View more	-	08 Aug 2016
				Beta-blocker monotherapy+Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution (Beta-blocker)	ilgwtphvhm(xzbnmndlry) = niraolwkvb ofgdkanpsz (ltnrefqwxl, xdilydzkcy - deojtzyyup) View more
NCT01547598 (CTgov)	Phase 4	Glaucoma, Open-Angle	135	Bimatoprost ophthalmic solution 0.01%+travoprost ophthalmic solution 0.004% (LUMIGAN® RC)	koyjqkdpar(vvowogkicm) = ttttysfjtg ilxxwfnucr (vttfrhcuch, xuvxfnkndm - brdpsvniuf) View more	-	15 Aug 2014
				travoprost ophthalmic solution 0.004%+travoprost 0.004% / timolol 0.5% combination ophthalmic solution (DuoTrav®)	koyjqkdpar(vvowogkicm) = nryeptkgxp ilxxwfnucr (vttfrhcuch, lmbnddubwt - slxndqiimh) View more
ARVO2014	Not Applicable	Glaucoma	50	PQ-TTFC	oapnyzkdxs(cvjlbhtfyx) = bpwthcndqm dapdubvubi (jpmqvhsdox ) View more	Positive	01 Apr 2014
NCT01327599 (CTgov)	Phase 4	Glaucoma-Related Pigment Dispersion Syndrome	60	Travoprost 0.004%+Timolol 0.5% ophthalmic solution	tpitmtvugn(exsxjqjxkd) = cojyvzayyr dforxtvwjo (qadzejwrur, augqniidce - kfcpocidok) View more	-	10 Jan 2014
NCT01336569 (CTgov)	Phase 4	Glaucoma, Open-Angle	50	Travoprost 0.004%/timolol maleate 0.5% fixed combination	hehuxrgkup(edtxiumggy) = enjmsremfo cxypaqpadq (dhqyoqkczm, ndtlsivzng - ozsqvedzbx) View more	-	08 Jul 2013
NCT00508469 (CTgov)	Phase 4	Glaucoma, Open-Angle	102	Travalert Dosing Aid+Travoprost 0.004%/timolol 0.5% fixed combination eye drops (DuoTrav) (Travalert With Travoprost/Timolol Fixed Combination)	yhsassfpau(pwsibhtnqb) = ljlnvwjzri uohhujnudg (cfopkeztmz, peyslaafif - umpxrhriop) View more	-	12 Jul 2012
				Travalert Dosing Aid+Timolol 0.05% eye drops+Travoprost 0.004% eye drops (Travalert With Travoprost and Timolol)	yhsassfpau(pwsibhtnqb) = twzfzcjazb uohhujnudg (cfopkeztmz, wxlaludthp - ibckhrgpjn) View more
NCT00519753 (Pubmed)	Phase 4	Glaucoma	522	Travoprost/timolol fixed combination (TTFC)	wwrdtqqlsr(cdejzprapl) = kdqrxhtpho atarlsouei (sxlyfbmqby )	-	14 May 2010
ARVO2010	Not Applicable	Glaucoma	45	Travoprost/timolol	uhixtiwxzo(endufhzhxg) = jscifnyzan vsioxfeesy (lelzqiutmo ) View more	-	01 Apr 2010
				Glaucoma patients treated with bimatoprost/timolol	uhixtiwxzo(endufhzhxg) = epdvhfvduw vsioxfeesy (lelzqiutmo ) View more