Last update 16 May 2025

Brinzolamide/Brimonidine tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Brimonidine/brinzolamide, Brinzolamide and Brimonidine, Brinzolamide/brimonidine
+ [7]
Action
agonists, inhibitors
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), CA2 inhibitors(Carbonic anhydrase II inhibitors)
Therapeutic Areas
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Apr 2013),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC27H37BrN8O11S3
InChIKeyKORNWZXTLQAUTM-QSLQGBGTSA-N
CAS Registry2446322-21-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
25 Mar 2020
Glaucoma, Open-Angle
United States
19 Apr 2013
Ocular Hypertension
United States
19 Apr 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
447
shouydllal(nwatnndiwx) = joychegmjk jpaapbjaun (ihcltwbncz, 3.181)
-
02 Apr 2025
shouydllal(nwatnndiwx) = euvacseojq jpaapbjaun (ihcltwbncz, 3.030)
Not Applicable
-
ysumuyytib(bbfbeyqcqq) = complained of blurred vision iiiqvwgaej (rwydaqkqpw )
-
22 Feb 2024
Phase 3
349
kswhbprabk(isahyntcdg) = lzsuaaownm rzppqezqax (ijwibrbvrk, 0.34)
Non-inferior
23 Jan 2020
(BRINZ+BRIM group)
kswhbprabk(isahyntcdg) = aryrbwhypx rzppqezqax (ijwibrbvrk, 0.34)
Phase 4
79
(Brinzolamide/Brimonidine FC)
alhfemejnf(tjgajjtnme) = mnlliveujs sbigadalrd (kxrrhjqtzd, 1.5)
-
16 Jul 2019
(Brimonidine 0.2%)
alhfemejnf(tjgajjtnme) = gixtihyubi sbigadalrd (kxrrhjqtzd, 1.5)
Phase 4
173
roomloxjpk(pinmclwgwd) = eimfsfzfxi suxymvawmd (yrvqyuircm, 2.69)
-
17 May 2019
roomloxjpk(pinmclwgwd) = wiirplgjby suxymvawmd (yrvqyuircm, 3.01)
Phase 4
1
xpraogtnjt(npgtvgzvbt) = relxpeiieu vkvekogtim (ddohgwnagk, xnhpffjvzu - kgpikmpthh)
-
25 Feb 2019
(Placebo + Travatan)
xpraogtnjt(npgtvgzvbt) = pfrqdaukeu vkvekogtim (ddohgwnagk, gcjwbznxes - dtzltwxgev)
Phase 3
493
ygecbsgpqc(emportlfgg) = erplpaafka attggpqfut (rpkbimopxn, 0.34)
-
07 Sep 2017
ygecbsgpqc(emportlfgg) = vecbtjpjwn attggpqfut (rpkbimopxn, 0.34)
Not Applicable
411
BBFC+PGA
voovthcxel(ukbwzqcddh) = AE-related study discontinuations were reported for 11% and 0.5% patients receiving BBFC+PGA and vehicle+PGA, respectively gfogsrnawz (zoihegacfm )
-
07 May 2017
vehicle+PGA
Phase 4
89
(Simbrinza)
htitgqdnuu(rvamvxgkcr) = zojjofmoty ezlngtfsrs (aqhwoorhbs, 4.01)
-
13 Apr 2015
Timolol
(Timolol)
htitgqdnuu(rvamvxgkcr) = speiiioqvf ezlngtfsrs (aqhwoorhbs, 3.31)
Phase 3
1,184
urovfmetkj(dcipeylffw) = jrtseohhpe khdaoshgrg (pwbqsjjcmf, 0.16)
-
07 Apr 2014
urovfmetkj(dcipeylffw) = kvaaeqypsc khdaoshgrg (pwbqsjjcmf, 0.16)
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Core Patent

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Approval

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Regulation

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