Last update 30 Jul 2025

Vitamin A

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol, all-trans-retinol, all-trans-retinyl alcohol
+ [12]
Target
Action
agonists
Mechanism
RARs agonists(Retinoic acid receptors agonists)
Originator Organization
Active Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (10 Aug 1976),
Regulation-
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Structure/Sequence

Molecular FormulaC20H30O
InChIKeyFPIPGXGPPPQFEQ-OVSJKPMPSA-N
CAS Registry68-26-8

External Link

KEGGWikiATCDrug Bank
D06543Vitamin A

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ichthyosis Vulgaris
Japan
08 Sep 1979
Pityriasis
Japan
08 Sep 1979
Keratomalacia
Japan
10 Aug 1976
Keratosis
Japan
10 Aug 1976
Night Blindness
Japan
10 Aug 1976
Vitamin a Deficiency
Japan
10 Aug 1976
Xerophthalmia---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bronchopulmonary DysplasiaPreclinical
Australia
01 Jul 2025
Retinopathy of PrematurityPreclinical
Australia
01 Jul 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
807
Vitamin A therapy
dqdvtcioqw(uedxhpsmfv): RR = 0.89 (95% CI, 0.8 - 0.99)
Positive
15 May 2021
(Control group)
Not Applicable
188
Enteral water-soluble vitamin A
jkwixozrzo(sihuorfnuk) = jlmuixpjrj msiviqckaa (vrfjxpslle )
-
01 Jan 2021
Placebo
jkwixozrzo(sihuorfnuk) = ikahzmuawc msiviqckaa (vrfjxpslle )
Not Applicable
112
Vitamin A supplementation
eweekmxrsg(grefpwagyk) = ovnahcavsq mtxduuwsaz (mrencblqfp )
-
01 Dec 2018
(Placebo)
eweekmxrsg(grefpwagyk) = jfpngxjglx mtxduuwsaz (mrencblqfp )
Phase 4
-
7,587
Vitamin A supplementation
wltgitbpaf(spsmimojim): MRR = 0.91 (95% CI, 0.59 - 1.41)
-
01 Sep 2014
(Placebo)
Phase 4
36
(With Multiple Sclerosis/ Vitamin A)
nvsajucsbe(sfomkclxdg) = nyodfsuvxt zrzpsaompq (epybomootq, 0.5)
-
14 Mar 2014
Placebo
(With Multiple Sclerosis/ Placebo)
nvsajucsbe(sfomkclxdg) = kmjekfkhpp zrzpsaompq (epybomootq, 0.4)
Not Applicable
250
Vitamin A supplementation
bysmzdezbo(zdlnnahgty) = fxvpyjrhue jknhammvuq (ntmfgitenu, 28.3 - 40.2)
Positive
31 Dec 2013
Phase 2
24
(Retinol)
uafqwytmdg(ckqqcwfgli) = pcctqedzjt qecqevaqbl (laawjeducc, 1.687)
-
20 Aug 2013
(Tretinoin)
uafqwytmdg(ckqqcwfgli) = tgzadqvliy qecqevaqbl (laawjeducc, 1.572)
Phase 4
-
1,673
amjeglkgot(uxbgvpdafm): RR = 0.86 (95% CI, 0.53 - 1.39)
-
28 Jun 2013
(Placebo)
Not Applicable
16
olqzgyucse(pprlmqgfdw) = aukghltbde bivobvdgus (mjqmdemugf, 0.68)
-
04 Dec 2012
Not Applicable
-
276
400,000 IU of vitamin A
pbyiulorke(ymjbhkxdwl): RR = 1.03 (95% CI, 0.88 - 1.21)
Negative
01 Apr 2012
200,000 IU of vitamin A
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Regulation

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