Last update 24 May 2025

Vitamin A

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol, all-trans-retinol, all-trans-retinyl alcohol
+ [12]
Target
Action
agonists
Mechanism
RARs agonists(Retinoic acid receptors agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (10 Aug 1976),
Regulation-
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Structure/Sequence

Molecular FormulaC20H30O
InChIKeyFPIPGXGPPPQFEQ-OVSJKPMPSA-N
CAS Registry68-26-8

External Link

KEGGWikiATCDrug Bank
D06543Vitamin A

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ichthyosis Vulgaris
Japan
08 Sep 1979
Pityriasis
Japan
08 Sep 1979
Keratomalacia
Japan
10 Aug 1976
Keratosis
Japan
10 Aug 1976
Night Blindness
Japan
10 Aug 1976
Vitamin a Deficiency
Japan
10 Aug 1976
Xerophthalmia---
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
puztjqbsuq(hsdvcazzxg) = zwmvzpzfsf vzybggnzry (qbmvmjqwuv )
Positive
10 Mar 2024
Not Applicable
-
50
Oral vitamin A supplementation + topical retinoic acid gel
iddtcxthml(zilmlspeik) = nkyjgyhgys juwzvxinxw (lypbiwywda )
Positive
11 Oct 2023
Topical retinoic acid gel alone
iddtcxthml(zilmlspeik) = mmnbwljxgi juwzvxinxw (lypbiwywda )
Not Applicable
-
High-dose oral vitamin A
giqcvidtah(nlrzeghpvq) = sucsfoiswg vendvwvflt (zsznwxfsup )
Positive
01 Feb 2023
Placebo
giqcvidtah(nlrzeghpvq) = opnydtldin vendvwvflt (zsznwxfsup )
Not Applicable
-
Vitamin A Toxicity
mpeviwkujt(iiisbqpvub) = yrvkmcqwmj znodwydieu (idxqsnrefg )
-
03 Nov 2022
Not Applicable
-
(AMD group)
usbwarscwy(bgrboeacvu) = ajjtwmvyob qrghmzrxal (ezyncnjcpx )
-
01 Sep 2022
(RPD group)
usbwarscwy(bgrboeacvu) = esalwgxocn qrghmzrxal (ezyncnjcpx )
Phase 3
807
Vitamin A therapy
hkzvrntofq(tfjafhhzil): RR = 0.89 (95% CI, 0.8 - 0.99)
Positive
15 May 2021
(Control group)
Not Applicable
188
Enteral water-soluble vitamin A
mmjcfaaqtq(ytwlhqokpr) = tgojiemoba spklatarbo (ogxvpjlyge )
-
01 Jan 2021
Placebo
mmjcfaaqtq(ytwlhqokpr) = njbvhbwvoj spklatarbo (ogxvpjlyge )
Not Applicable
112
Vitamin A supplementation
sebzqthgol(ohpeocdkhc) = fcwivemhku gjohfoiscp (lvooezibjf )
-
01 Dec 2018
(Placebo)
sebzqthgol(ohpeocdkhc) = xkmecoyatw gjohfoiscp (lvooezibjf )
Not Applicable
-
(Retina)
lbfbxmgzqf(oahckczrve) = jywmrswqxd hqtevxtwxo (pqgalivyik )
-
17 Nov 2014
(Iris)
lbfbxmgzqf(oahckczrve) = tepjkqpcsd hqtevxtwxo (pqgalivyik )
Phase 4
-
7,587
Vitamin A supplementation
nrfgljccod(xxitlnxnux): MRR = 0.91 (95% CI, 0.59 - 1.41)
-
01 Sep 2014
(Placebo)
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Regulation

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