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Last update 17 Nov 2025
Alveltamig
Last update 17 Nov 2025
Overview
Basic Info
Drug Type Trispecific T-cell engager (TriTE) |
Synonyms ZG 006, ZG-006, ZG006 |
Target |
Action stimulants, inhibitors |
Mechanism CD3 stimulants(T cell surface glycoprotein CD3 stimulants), DLL3 inhibitors(Delta-like protein 3 inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States), Breakthrough Therapy (China) |
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Related
8
Clinical Trials associated with AlveltamigNCT07189455
A Multicenter, Randomized, Controlled, Open-Label Phase III Study Evaluating the Efficacy and Safety of ZG006 for Injection Compared With Investigator-Selected Chemotherapy in Participants With Relapsed Small Cell Lung Cancer
NCT07024277
A Phase II Study Evaluating the Preliminary Efficacy and Safety of ZG006 in Participants With Metastatic Neuroendocrine Prostate Cancer
NCT07038096
A Phase Ib/II Study of the Tolerability, Safety, Efficacy, and Pharmacokinetics of ZG006 in Combination With ZG005 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma(NEC)
100 Clinical Results associated with Alveltamig
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100 Translational Medicine associated with Alveltamig
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100 Patents (Medical) associated with Alveltamig
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100 Deals associated with Alveltamig
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Recurrent Lung Small Cell Carcinoma | Phase 3 | China | 23 Sep 2025 | |
| Neuroendocrine Carcinoma | Phase 2 | - | 01 Aug 2025 | |
| Prostate Neuroendocrine Carcinoma | Phase 2 | China | 10 Jun 2025 | |
| Large cell neuroendocrine carcinoma of lung | Phase 2 | China | 13 Aug 2024 | |
| Advanced Neuroendocrine Carcinoma | Phase 2 | China | 12 Aug 2024 | |
| Advanced Lung Small Cell Carcinoma | Phase 2 | China | 19 Oct 2023 | |
| Extensive stage Small Cell Lung Cancer | Phase 1 | China | 05 Nov 2025 | |
| Small Cell Lung Cancer | Phase 1 | United States | 31 Mar 2025 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1/2 | - | iytxgnxkmj(ptkuwwyndd) = xotevhcmno typftlztlc (pefpdddcag ) View more | Positive | 11 Sep 2025 | |||
iytxgnxkmj(ptkuwwyndd) = jihggtftwj typftlztlc (pefpdddcag ) View more | |||||||
Phase 2 | Advanced Lung Small Cell Carcinoma Third line | 60 | hlyaadmbvp(wniybzbzyr) = cnmioncdtr wsclufcoff (iyuuntgmbd ) View more | Positive | 11 Sep 2025 | ||
hlyaadmbvp(wniybzbzyr) = gjqqezfblh wsclufcoff (iyuuntgmbd ) View more | |||||||
Phase 2 | Advanced Neuroendocrine Carcinoma Second line | 53 | ikvfkdmlsy(erfcahvilb) = mlqawxjbyh hyrurgjhgm (hctdkxdyin ) View more | Positive | 11 Sep 2025 | ||
ikvfkdmlsy(erfcahvilb) = esmkbvtltu hyrurgjhgm (hctdkxdyin ) View more | |||||||
Phase 1 | 45 | srwsjgsrsc(wduivqrpwc) = pkpblwbzua ijuncvehmo (ytdnwjloct ) View more | Positive | 30 May 2025 | |||
Phase 2 | 17 | acioyeuxcl(eiqquqvxmw) = qanfpmllfk tvgbivkhbg (ufaeaxerxz ) View more | Positive | 30 May 2025 | |||
Phase 2 | 40 | bkozpywpmo(dqhepfbdzm) = whhbmhlqqp drfoalbvlx (tuspgdnwze ) View more | Positive | 30 May 2025 | |||
bkozpywpmo(dqhepfbdzm) = satasmajjj drfoalbvlx (tuspgdnwze ) View more | |||||||
Phase 1/2 | 24 | mqwxroinsk(jnnyuhfday) = 绝大多数治疗相关不良事件（TRAEs）的严重程度为1级或2级。最常见的TRAEs为发热、贫血和细胞因子释放综合征（CRS，3级CRS 1例）。 wfhhwdcaxk (xykbzkgxsl ) View more | Positive | 25 Sep 2024 |
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