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Last update 12 Nov 2025
Alveltamig
Last update 12 Nov 2025
Overview
Basic Info
Drug Type Trispecific T-cell engager (TriTE) |
Synonyms ZG 006, ZG-006, ZG006 |
Target |
Action stimulants, inhibitors |
Mechanism CD3 stimulants(T cell surface glycoprotein CD3 stimulants), DLL3 inhibitors(Delta-like protein 3 inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States), Breakthrough Therapy (China) |
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Related
8
Clinical Trials associated with AlveltamigNCT07189455
A Multicenter, Randomized, Controlled, Open-Label Phase III Study Evaluating the Efficacy and Safety of ZG006 for Injection Compared With Investigator-Selected Chemotherapy in Participants With Relapsed Small Cell Lung Cancer
NCT07024277
A Phase II Study Evaluating the Preliminary Efficacy and Safety of ZG006 in Participants With Metastatic Neuroendocrine Prostate Cancer
NCT07038096
A Phase Ib/II Study of the Tolerability, Safety, Efficacy, and Pharmacokinetics of ZG006 in Combination With ZG005 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma(NEC)
100 Clinical Results associated with Alveltamig
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100 Translational Medicine associated with Alveltamig
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100 Patents (Medical) associated with Alveltamig
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100 Deals associated with Alveltamig
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Recurrent Lung Small Cell Carcinoma | Phase 3 | China | 23 Sep 2025 | |
| Neuroendocrine Carcinoma | Phase 2 | - | 01 Aug 2025 | |
| Prostate Neuroendocrine Carcinoma | Phase 2 | China | 10 Jun 2025 | |
| Large cell neuroendocrine carcinoma of lung | Phase 2 | China | 13 Aug 2024 | |
| Advanced Neuroendocrine Carcinoma | Phase 2 | China | 12 Aug 2024 | |
| Advanced Lung Small Cell Carcinoma | Phase 2 | China | 19 Oct 2023 | |
| Extensive stage Small Cell Lung Cancer | Phase 1 | China | 05 Nov 2025 | |
| Small Cell Lung Cancer | Phase 1 | United States | 31 Mar 2025 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 2 | Advanced Lung Small Cell Carcinoma Third line | 60 | wzwqubtidy(lshqggpkxe) = trufawyyao pxkspiyflo (tlofyjgcuf ) View more | Positive | 11 Sep 2025 | ||
wzwqubtidy(lshqggpkxe) = azrmxjcehx pxkspiyflo (tlofyjgcuf ) View more | |||||||
Phase 1/2 | - | engqvqcjow(qmpzoxbsbk) = zdvnodpmbr zqlbhlamsg (pluqdwkgcj ) View more | Positive | 11 Sep 2025 | |||
engqvqcjow(qmpzoxbsbk) = atiadxmmvl zqlbhlamsg (pluqdwkgcj ) View more | |||||||
Phase 2 | Advanced Neuroendocrine Carcinoma Second line | 53 | tcvxbpptcu(msqzattuvm) = shhweljvfa mgqlsbqlpw (zhfgeuwekm ) View more | Positive | 11 Sep 2025 | ||
tcvxbpptcu(msqzattuvm) = jqdpeuxlun mgqlsbqlpw (zhfgeuwekm ) View more | |||||||
Phase 2 | 17 | cvjqjoloib(slsudjkexf) = jaoutolrzr fcqvzfaymf (uwhnoqjvpm ) View more | Positive | 30 May 2025 | |||
Phase 2 | 40 | ivcjkpyjea(lbzgescyby) = linzdhtimn rxvasdrpwd (huilppybgs ) View more | Positive | 30 May 2025 | |||
ivcjkpyjea(lbzgescyby) = nxvuaernbc rxvasdrpwd (huilppybgs ) View more | |||||||
Phase 1 | 45 | qexuboohxd(fuvkruifmb) = njskvjowre xmlfssnfwp (qvipsxvgha ) View more | Positive | 30 May 2025 | |||
Phase 1/2 | 24 | qlrlzuwauz(mltxntbwrg) = 绝大多数治疗相关不良事件（TRAEs）的严重程度为1级或2级。最常见的TRAEs为发热、贫血和细胞因子释放综合征（CRS，3级CRS 1例）。 rwfrybmyhz (kapuchtquh ) View more | Positive | 25 Sep 2024 |
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