Last update 07 Mar 2025

ONCOS-102

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
AD5/3-D24-GMCSF, ADV5/3-D24-GM-CSF, CGTG-102
+ [1]
Target
Mechanism
CSF-2R stimulants(Granulocyte-macrophage colony-stimulating factor receptor stimulants)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Orphan Drug (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MelanomaPhase 2-01 Jan 2024
MesotheliomaPhase 2
FR
12 Jun 2018
MesotheliomaPhase 2
ES
12 Jun 2018
Prostatic CancerPhase 2
CZ
24 May 2018
Appendiceal NeoplasmsPhase 2
US
07 Sep 2017
Appendiceal NeoplasmsPhase 2
US
07 Sep 2017
Metastatic Colorectal CarcinomaPhase 2
US
07 Sep 2017
Metastatic Colorectal CarcinomaPhase 2
US
07 Sep 2017
Ovarian Epithelial CarcinomaPhase 2
US
07 Sep 2017
Ovarian Epithelial CarcinomaPhase 2
US
07 Sep 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
31
ONCOS-102 + Pemetrexed or cisplatin
kanlvdiqjl(kqyvfxnmil) = oaqggvjbpd xatnhvnxdt (vbdjygkupz )
Positive
31 May 2023
Pemetrexed or cisplatin
kanlvdiqjl(kqyvfxnmil) = oqtsgvleiw xatnhvnxdt (vbdjygkupz )
Phase 1/2
67
(Cohort A: ONCOS-102 Dose Escalation)
wwiqdtlamh(spmpnijxoz) = vufplkenem yihccijdoa (blvstpptqn, qvhpjjlxhn - sdndhwgmql)
-
22 Dec 2022
(Cohort 1: Epithelial Ovarian Cancer)
wwiqdtlamh(spmpnijxoz) = xbpvydbipo yihccijdoa (blvstpptqn, bpswfoavvl - zdndtovegp)
Phase 1/2
Refractory Melanoma
GM-CSF-encoding oncolytic adenovirus | pembrolizumab
21
sjwrtxqgxx(tsqwlnpmon) = 33% gvfpgtpfir (servljbdlf )
Positive
07 Nov 2022
Phase 1/2
25
ONCOS-102 + P/C
qhextnhrmc(cdlqdvwkva) = houatumnno qhramatmwd (dywtluppbn )
-
02 Jun 2022
P/C
qhextnhrmc(cdlqdvwkva) = gsacrdghit qhramatmwd (dywtluppbn )
Phase 1/2
-
ONCOS-102 + pemetrexed/cisplatin
jixdwkclpb(tvzxbdtczi) = hsssirztuk lyluukvzqw (gnjodmsjiv )
Positive
10 Nov 2021
pemetrexed/cisplatin
jixdwkclpb(tvzxbdtczi) = fcjmjcjhkd lyluukvzqw (gnjodmsjiv )
Phase 1
21
qijipmdlsd(zoqrzghfpk) = pyrexia (10%), chills (8%), nausea and hypertension (4%) wusfsqvkng (jcnkervlbn )
Positive
16 Sep 2021
Phase 1
21
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 1)
zzbpzvzidt(tkokpdlfkx) = xbfsilryoa vwznlcbpmb (jbkiugvggc, gcmtbvdgjp - eatoitfycr)
-
09 Aug 2021
(Experimental: ONCOS-102+Cyclophosphamide+Pembrolizumab Part 2)
zzbpzvzidt(tkokpdlfkx) = icqvymduds vwznlcbpmb (jbkiugvggc, unusuvbcly - fcutkoxisv)
Phase 1/2
-
ONCOS-102 + pemetrexed/cisplatin
oprfxpknzb(jahtspamqh) = psmyrmfgzy pglblcdhvk (jelbohzmov )
Positive
10 Dec 2020
pemetrexed/cisplatin
oprfxpknzb(jahtspamqh) = kgnpgxiobm pglblcdhvk (jelbohzmov )
Phase 1/2
31
Standard of Care+ONCOS-102
nofzuqatnn(ybfdbshyaf) = dijzfdqich vjkzvqdqio (oescvrldxn )
Positive
24 Nov 2020
Standard of Care
nofzuqatnn(ybfdbshyaf) = stysfkwcmi vjkzvqdqio (oescvrldxn )
Phase 1/2
17
tmndpggakg(erminczmfv) = hypokalemia (n = 2); anemia, myocarditis, increased GGT, and influenza like illness (n = 1 each) eugkjbymch (fdyuuggohx )
Positive
29 May 2020
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