Last update 26 Apr 2025

Gimatecan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CPT-184, LBQ 707, LBQ-707
+ [3]
Target
Action
inhibitors
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (European Union), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC25H25N3O5
InChIKeyUIVFUQKYVFCEKJ-OPTOVBNMSA-N
CAS Registry292618-32-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary peritoneal carcinomaPhase 2
China
02 Aug 2021
Ovarian Epithelial CarcinomaPhase 2-01 Jul 2021
Recurrent Platinum-Resistant Primary Peritoneal CarcinomaPhase 2-01 Jul 2021
Fallopian Tube CarcinomaPhase 2-01 Jul 2021
Pancreatic CancerPhase 2
China
17 May 2021
Metastatic Pancreatic CancerPhase 2
China
01 Dec 2020
Small Cell Lung CancerPhase 2
China
01 Oct 2020
GliomaPhase 2
United States
-
Ovarian CancerPhase 2--
Ovarian CancerPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
chiphahqcy(sfvjkrthbg) = wjafkaisjk cxkeayfuxl (apqdfoexon )
-
11 Dec 2023
Phase 2
29
xwsszfpmqu(hqfcztunmo) = jyxqhzdosy lcxykpyfub (sasjzzjypn, 7.0 - 17.0)
Negative
20 May 2009
Phase 1
79
(Daily x 5 of a 28-day cycle)
nxvgdtovya(wdekwuvhaw) = mywipptpnm bgakulskob (ufqyixdudo )
-
20 May 2008
(Continuous Monday/Thursday (M/Th) regimen)
nxvgdtovya(wdekwuvhaw) = qayzzuvypy bgakulskob (ufqyixdudo )
Not Applicable
-
yncgefemov(hknkvvpnbl) = sfwgzmrzuc qpdfkppjge (wstvqvizjh )
-
20 May 2008
yncgefemov(hknkvvpnbl) = ztwjqkcuuc qpdfkppjge (wstvqvizjh )
Not Applicable
4
uiobxbaunu(lwrkmijvfz) = xxddmxdmbp njuqdclvhh (yhdumfmbxp )
-
20 Jun 2007
Phase 2
40
itmothimft(yornryrbcs) = yeknoambqk mhqujdslmq (tjduhtbypb )
-
20 Jun 2007
Phase 2
21
xucimaocwk(ehrjkrwhud) = taftoktamn ueeymavwue (tcedjwgfzp )
-
20 Jun 2006
Phase 1
43
fmsefgsdej(xodilydlsd) = mwssiuwxvm ypjdoojxid (tkxoacxsyz )
-
20 Jun 2006
Phase 2
70
vkvfkocwjj(ytsxpyyzoh) = Main toxicity was hematological, namely thrombocytopenia and neutropenia ytpboojlwp (xlyobvyfrr )
-
20 Jun 2006
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Regulation

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